Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial
Adolescence is a time for rapid growth that represents an opportunity to influence peak bone mass. Prebiotic agents, such as galacto-oligosaccharides (GOS), increase Ca absorption in animal models and postmenopausal women. The objectives of the present study were to investigate the dose–response rel...
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| Veröffentlicht in: | British journal of nutrition 2013-10, Vol.110 (7), p.1292-1303 |
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| creator | Whisner, Corrie M. Martin, Berdine R. Schoterman, Margriet H. C. Nakatsu, Cindy H. McCabe, Linda D. McCabe, George P. Wastney, Meryl E. van den Heuvel, Ellen G. H. M. Weaver, Connie M. |
| description | Adolescence is a time for rapid growth that represents an opportunity to influence peak bone mass. Prebiotic agents, such as galacto-oligosaccharides (GOS), increase Ca absorption in animal models and postmenopausal women. The objectives of the present study were to investigate the dose–response relationship of GOS supplementation on Ca absorption during growth and to assess changes in colonic microbiota to better understand the mechanism by which GOS is acting. A total of thirty-one healthy adolescent girls aged 10–13 years consumed smoothie drinks twice daily with 0, 2·5 or 5 g GOS for three 3-week periods in a random order. Fractional Ca absorption was determined from urinary Ca excretion over 48 h at the end of each 3-week period using a dual stable isotope method. Faecal microbiota and bifidobacteria were assessed by PCR–denaturing gradient gel electrophoresis and quantitative PCR. Fractional Ca absorption after the 48 h treatment with control, 5 and 10 g GOS/d was 0·393 (sd 0·092), 0·444 (sd 0·086) and 0·419 (sd 0·099), respectively. Significant improvements in Ca absorption were seen with both low and high doses of GOS compared with the control (P |
| doi_str_mv | 10.1017/S000711451300055X |
| format | Article |
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C. ; Nakatsu, Cindy H. ; McCabe, Linda D. ; McCabe, George P. ; Wastney, Meryl E. ; van den Heuvel, Ellen G. H. M. ; Weaver, Connie M.</creator><creatorcontrib>Whisner, Corrie M. ; Martin, Berdine R. ; Schoterman, Margriet H. C. ; Nakatsu, Cindy H. ; McCabe, Linda D. ; McCabe, George P. ; Wastney, Meryl E. ; van den Heuvel, Ellen G. H. M. ; Weaver, Connie M.</creatorcontrib><description>Adolescence is a time for rapid growth that represents an opportunity to influence peak bone mass. Prebiotic agents, such as galacto-oligosaccharides (GOS), increase Ca absorption in animal models and postmenopausal women. The objectives of the present study were to investigate the dose–response relationship of GOS supplementation on Ca absorption during growth and to assess changes in colonic microbiota to better understand the mechanism by which GOS is acting. A total of thirty-one healthy adolescent girls aged 10–13 years consumed smoothie drinks twice daily with 0, 2·5 or 5 g GOS for three 3-week periods in a random order. Fractional Ca absorption was determined from urinary Ca excretion over 48 h at the end of each 3-week period using a dual stable isotope method. Faecal microbiota and bifidobacteria were assessed by PCR–denaturing gradient gel electrophoresis and quantitative PCR. Fractional Ca absorption after the 48 h treatment with control, 5 and 10 g GOS/d was 0·393 (sd 0·092), 0·444 (sd 0·086) and 0·419 (sd 0·099), respectively. Significant improvements in Ca absorption were seen with both low and high doses of GOS compared with the control (P< 0·02), but it was not a dose–response relationship. The increase in absorption was greatest in the urine collected after 24 h, which is consistent with lower gut absorption. Faecal bifidobacteria increased (control 10·89 (sd 13·86), 5 g GOS 22·80 (sd 15·74) and 10 g GOS 11·54 (sd 14·20)) with the GOS treatment (P< 0·03). The results suggest that daily consumption of 5 g GOS increases Ca absorption, which may be mediated by the gut microbiota, specifically bifidobacteria.</description><identifier>ISSN: 0007-1145</identifier><identifier>EISSN: 1475-2662</identifier><identifier>DOI: 10.1017/S000711451300055X</identifier><identifier>PMID: 23507173</identifier><identifier>CODEN: BJNUAV</identifier><language>eng</language><publisher>Cambridge, UK: Cambridge University Press</publisher><subject>Absorption ; Adolescent ; Adolescents ; Animal models ; Bacteria ; Bifidobacterium ; Biological and medical sciences ; Bones ; Calcium ; Calcium - metabolism ; Calcium - urine ; Calcium, Dietary - metabolism ; Calcium, Dietary - urine ; Child ; Children & youth ; Dietary supplements ; Digestive system ; Double-Blind Method ; Feces - microbiology ; Feeding. Feeding behavior ; Female ; Fundamental and applied biological sciences. Psychology ; Galactose - pharmacology ; Human and Clinical Nutrition ; Humans ; Intestinal Absorption ; Intestines - microbiology ; Oligosaccharides - pharmacology ; Stable isotopes ; Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><ispartof>British journal of nutrition, 2013-10, Vol.110 (7), p.1292-1303</ispartof><rights>Copyright © The Authors 2013</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c545t-8bcb73267d21135a8cbb4ca5063125a66b21029cead88fea06baab7c0fb732803</citedby><cites>FETCH-LOGICAL-c545t-8bcb73267d21135a8cbb4ca5063125a66b21029cead88fea06baab7c0fb732803</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.cambridge.org/core/product/identifier/S000711451300055X/type/journal_article$$EHTML$$P50$$Gcambridge$$H</linktohtml><link.rule.ids>164,314,776,780,27903,27904,55606</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=27801387$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23507173$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Whisner, Corrie M.</creatorcontrib><creatorcontrib>Martin, Berdine R.</creatorcontrib><creatorcontrib>Schoterman, Margriet H. C.</creatorcontrib><creatorcontrib>Nakatsu, Cindy H.</creatorcontrib><creatorcontrib>McCabe, Linda D.</creatorcontrib><creatorcontrib>McCabe, George P.</creatorcontrib><creatorcontrib>Wastney, Meryl E.</creatorcontrib><creatorcontrib>van den Heuvel, Ellen G. H. M.</creatorcontrib><creatorcontrib>Weaver, Connie M.</creatorcontrib><title>Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial</title><title>British journal of nutrition</title><addtitle>Br J Nutr</addtitle><description>Adolescence is a time for rapid growth that represents an opportunity to influence peak bone mass. Prebiotic agents, such as galacto-oligosaccharides (GOS), increase Ca absorption in animal models and postmenopausal women. The objectives of the present study were to investigate the dose–response relationship of GOS supplementation on Ca absorption during growth and to assess changes in colonic microbiota to better understand the mechanism by which GOS is acting. A total of thirty-one healthy adolescent girls aged 10–13 years consumed smoothie drinks twice daily with 0, 2·5 or 5 g GOS for three 3-week periods in a random order. Fractional Ca absorption was determined from urinary Ca excretion over 48 h at the end of each 3-week period using a dual stable isotope method. Faecal microbiota and bifidobacteria were assessed by PCR–denaturing gradient gel electrophoresis and quantitative PCR. Fractional Ca absorption after the 48 h treatment with control, 5 and 10 g GOS/d was 0·393 (sd 0·092), 0·444 (sd 0·086) and 0·419 (sd 0·099), respectively. Significant improvements in Ca absorption were seen with both low and high doses of GOS compared with the control (P< 0·02), but it was not a dose–response relationship. The increase in absorption was greatest in the urine collected after 24 h, which is consistent with lower gut absorption. Faecal bifidobacteria increased (control 10·89 (sd 13·86), 5 g GOS 22·80 (sd 15·74) and 10 g GOS 11·54 (sd 14·20)) with the GOS treatment (P< 0·03). The results suggest that daily consumption of 5 g GOS increases Ca absorption, which may be mediated by the gut microbiota, specifically bifidobacteria.</description><subject>Absorption</subject><subject>Adolescent</subject><subject>Adolescents</subject><subject>Animal models</subject><subject>Bacteria</subject><subject>Bifidobacterium</subject><subject>Biological and medical sciences</subject><subject>Bones</subject><subject>Calcium</subject><subject>Calcium - metabolism</subject><subject>Calcium - urine</subject><subject>Calcium, Dietary - metabolism</subject><subject>Calcium, Dietary - urine</subject><subject>Child</subject><subject>Children & youth</subject><subject>Dietary supplements</subject><subject>Digestive system</subject><subject>Double-Blind Method</subject><subject>Feces - microbiology</subject><subject>Feeding. Feeding behavior</subject><subject>Female</subject><subject>Fundamental and applied biological sciences. Psychology</subject><subject>Galactose - pharmacology</subject><subject>Human and Clinical Nutrition</subject><subject>Humans</subject><subject>Intestinal Absorption</subject><subject>Intestines - microbiology</subject><subject>Oligosaccharides - pharmacology</subject><subject>Stable isotopes</subject><subject>Vertebrates: anatomy and physiology, studies on body, several organs or systems</subject><issn>0007-1145</issn><issn>1475-2662</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkU1rFjEUhUOx2Ne2P6AbCYjgZmo-Jh_jrhStQsGFFrobbjKZaUpm8prMCMU_b8a-2lIRXCXhPufce3MQOqHklBKq3n4hhChKa0F5uQlxvYc2tFaiYlKyZ2izlqu1foBe5HxbnpqS5jk6YFwUoeIb9OMCAtg5VjH4IWaw9gaS71zGfrLJQXbYQrB-GTGYHNN29nHCMHV4WGZsfO-7aIqBSx6KBN_FZRrw4FPI7zDgLi4muMoEXxQ2xZyr-N0lPBc8HKH9HkJ2x7vzEF19eP_1_GN1-fni0_nZZWVFLeZKG2sUZ1J1jFIuQFtjaguCSE6ZACkNo4Q11kGnde-ASANglCX9KtOEH6I3977bFL8tLs_t6LN1IcDk4pJbWjdMctXw_0F5-XAtmSroqyfobVzSVBZZKaE5b5goFL2nfi2fXN9ukx8h3bWUtGuI7V8hFs3LnfNiRtf9UfxOrQCvdwDkkk6fYLI-P3BKE8r1OiLfNYfRlFQH92jGf7b_CQvgs80</recordid><startdate>20131014</startdate><enddate>20131014</enddate><creator>Whisner, Corrie M.</creator><creator>Martin, Berdine R.</creator><creator>Schoterman, Margriet H. 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C. ; Nakatsu, Cindy H. ; McCabe, Linda D. ; McCabe, George P. ; Wastney, Meryl E. ; van den Heuvel, Ellen G. H. 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Psychology</topic><topic>Galactose - pharmacology</topic><topic>Human and Clinical Nutrition</topic><topic>Humans</topic><topic>Intestinal Absorption</topic><topic>Intestines - microbiology</topic><topic>Oligosaccharides - pharmacology</topic><topic>Stable isotopes</topic><topic>Vertebrates: anatomy and physiology, studies on body, several organs or systems</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Whisner, Corrie M.</creatorcontrib><creatorcontrib>Martin, Berdine R.</creatorcontrib><creatorcontrib>Schoterman, Margriet H. C.</creatorcontrib><creatorcontrib>Nakatsu, Cindy H.</creatorcontrib><creatorcontrib>McCabe, Linda D.</creatorcontrib><creatorcontrib>McCabe, George P.</creatorcontrib><creatorcontrib>Wastney, Meryl E.</creatorcontrib><creatorcontrib>van den Heuvel, Ellen G. H. M.</creatorcontrib><creatorcontrib>Weaver, Connie M.</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Immunology Abstracts</collection><collection>Agricultural Science Collection</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Public Health Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest One Sustainability</collection><collection>ProQuest Central UK/Ireland</collection><collection>British Nursing Database</collection><collection>Agricultural & Environmental Science Collection</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Natural Science Collection (ProQuest)</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Agricultural Science Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>British journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Whisner, Corrie M.</au><au>Martin, Berdine R.</au><au>Schoterman, Margriet H. C.</au><au>Nakatsu, Cindy H.</au><au>McCabe, Linda D.</au><au>McCabe, George P.</au><au>Wastney, Meryl E.</au><au>van den Heuvel, Ellen G. H. M.</au><au>Weaver, Connie M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial</atitle><jtitle>British journal of nutrition</jtitle><addtitle>Br J Nutr</addtitle><date>2013-10-14</date><risdate>2013</risdate><volume>110</volume><issue>7</issue><spage>1292</spage><epage>1303</epage><pages>1292-1303</pages><issn>0007-1145</issn><eissn>1475-2662</eissn><coden>BJNUAV</coden><abstract>Adolescence is a time for rapid growth that represents an opportunity to influence peak bone mass. Prebiotic agents, such as galacto-oligosaccharides (GOS), increase Ca absorption in animal models and postmenopausal women. The objectives of the present study were to investigate the dose–response relationship of GOS supplementation on Ca absorption during growth and to assess changes in colonic microbiota to better understand the mechanism by which GOS is acting. A total of thirty-one healthy adolescent girls aged 10–13 years consumed smoothie drinks twice daily with 0, 2·5 or 5 g GOS for three 3-week periods in a random order. Fractional Ca absorption was determined from urinary Ca excretion over 48 h at the end of each 3-week period using a dual stable isotope method. Faecal microbiota and bifidobacteria were assessed by PCR–denaturing gradient gel electrophoresis and quantitative PCR. Fractional Ca absorption after the 48 h treatment with control, 5 and 10 g GOS/d was 0·393 (sd 0·092), 0·444 (sd 0·086) and 0·419 (sd 0·099), respectively. Significant improvements in Ca absorption were seen with both low and high doses of GOS compared with the control (P< 0·02), but it was not a dose–response relationship. The increase in absorption was greatest in the urine collected after 24 h, which is consistent with lower gut absorption. Faecal bifidobacteria increased (control 10·89 (sd 13·86), 5 g GOS 22·80 (sd 15·74) and 10 g GOS 11·54 (sd 14·20)) with the GOS treatment (P< 0·03). The results suggest that daily consumption of 5 g GOS increases Ca absorption, which may be mediated by the gut microbiota, specifically bifidobacteria.</abstract><cop>Cambridge, UK</cop><pub>Cambridge University Press</pub><pmid>23507173</pmid><doi>10.1017/S000711451300055X</doi><tpages>12</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of nutrition, 2013-10, Vol.110 (7), p.1292-1303 |
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| source | MEDLINE; EZB-FREE-00999 freely available EZB journals; Free Full-Text Journals in Chemistry; Cambridge University Press Journals Complete |
| subjects | Absorption Adolescent Adolescents Animal models Bacteria Bifidobacterium Biological and medical sciences Bones Calcium Calcium - metabolism Calcium - urine Calcium, Dietary - metabolism Calcium, Dietary - urine Child Children & youth Dietary supplements Digestive system Double-Blind Method Feces - microbiology Feeding. Feeding behavior Female Fundamental and applied biological sciences. Psychology Galactose - pharmacology Human and Clinical Nutrition Humans Intestinal Absorption Intestines - microbiology Oligosaccharides - pharmacology Stable isotopes Vertebrates: anatomy and physiology, studies on body, several organs or systems |
| title | Galacto-oligosaccharides increase calcium absorption and gut bifidobacteria in young girls: a double-blind cross-over trial |
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