Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors
Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor. A total of 60 A/J mice were randomized to a normal diet, a d...
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| Veröffentlicht in: | Anticancer research 2013-11, Vol.33 (11), p.4767-4770 |
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| creator | Pommergaard, Hans-Christian Burcharth, Jakob Rosenberg, J Raskov, Hans |
| description | Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor.
A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.
The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p |
| format | Article |
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A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.
The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed.
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A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.
The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed.
The chemoprevention diet had a protective effect against tumor development in the mouse lungs.</description><subject>Acetylsalicylic acid</subject><subject>Animals</subject><subject>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</subject><subject>Aspirin - administration & dosage</subject><subject>Bone Density Conservation Agents - administration & dosage</subject><subject>Calcium, Dietary - administration & dosage</subject><subject>Carcinogens - toxicity</subject><subject>Diet</subject><subject>Disease Models, Animal</subject><subject>Lung Neoplasms - chemically induced</subject><subject>Lung Neoplasms - pathology</subject><subject>Lung Neoplasms - prevention & control</subject><subject>Mice</subject><subject>Mice, Inbred A</subject><subject>Vitamin D - administration & dosage</subject><issn>1791-7530</issn><issn>0250-7005</issn><issn>1791-7530</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkM1OwzAQhC0EoqXwCshHDkTyXxrniAoUpEpc4By59ro1JHawnaK-PQGKxJHDanZmP-1hjtCUVjUtqpKT4z_7BJ2l9ErIfF5LfoomTDDGKKVTFBZb6EIfYQc-u-Dxh8tbrDTkfZtU6_R-nNE7c413LqvOeXyLlTdYq1a7ocMRzKAh4ejSGw52zKN2PmzAF85_nQxuB7_BeehCTOfoxKo2wcVBZ-jl_u558VCsnpaPi5tV0TMhcmE5SMopwJqUoNecW2KYsSCkproU2lhLKKGSCK346KW11jBVS1aVlDHLZ-jq528fw_sAKTedSxraVnkIQ2qoqNmcc1LV_0BLWRJefqOXB3RYd2CaPrpOxX3z2yf_BIqMdBs</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Pommergaard, Hans-Christian</creator><creator>Burcharth, Jakob</creator><creator>Rosenberg, J</creator><creator>Raskov, Hans</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>201311</creationdate><title>Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors</title><author>Pommergaard, Hans-Christian ; Burcharth, Jakob ; Rosenberg, J ; Raskov, Hans</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p244t-f3e8131eeb05ecb33f0d2dfe48c1c54cdff0101804ca354c8fffd2a98275122f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acetylsalicylic acid</topic><topic>Animals</topic><topic>Anti-Inflammatory Agents, Non-Steroidal - administration & dosage</topic><topic>Aspirin - administration & dosage</topic><topic>Bone Density Conservation Agents - administration & dosage</topic><topic>Calcium, Dietary - administration & dosage</topic><topic>Carcinogens - toxicity</topic><topic>Diet</topic><topic>Disease Models, Animal</topic><topic>Lung Neoplasms - chemically induced</topic><topic>Lung Neoplasms - pathology</topic><topic>Lung Neoplasms - prevention & control</topic><topic>Mice</topic><topic>Mice, Inbred A</topic><topic>Vitamin D - administration & dosage</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pommergaard, Hans-Christian</creatorcontrib><creatorcontrib>Burcharth, Jakob</creatorcontrib><creatorcontrib>Rosenberg, J</creatorcontrib><creatorcontrib>Raskov, Hans</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>MEDLINE - Academic</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Anticancer research</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pommergaard, Hans-Christian</au><au>Burcharth, Jakob</au><au>Rosenberg, J</au><au>Raskov, Hans</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors</atitle><jtitle>Anticancer research</jtitle><addtitle>Anticancer Res</addtitle><date>2013-11</date><risdate>2013</risdate><volume>33</volume><issue>11</issue><spage>4767</spage><epage>4770</epage><pages>4767-4770</pages><issn>1791-7530</issn><issn>0250-7005</issn><eissn>1791-7530</eissn><abstract>Research has shown that chemoprevention may be effective against the development of lung cancer. The purpose of the present study was to evaluate the effect of oral chemoprevention in a mouse model of tobacco carcinogen-induced lung tumor.
A total of 60 A/J mice were randomized to a normal diet, a diet with low calcium, or a chemoprevention diet with acetylsalicylic acid, 1-α 25(0H)2-vitamin D3 and calcium. In addition to the diet, mice received carcinogens by oral gavage for ten weeks.
The chemoprevention diet significantly reduced the number of animals with tumors [1 vs. 13, (p<0.001)] and the median number (range) of tumors [0 (0-1) vs. 1 (0-4), (p<0.001)] compared to controls. No signs of toxicity in relation to the diets were observed.
The chemoprevention diet had a protective effect against tumor development in the mouse lungs.</abstract><cop>Greece</cop><pmid>24222111</pmid><tpages>4</tpages></addata></record> |
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| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals |
| subjects | Acetylsalicylic acid Animals Anti-Inflammatory Agents, Non-Steroidal - administration & dosage Aspirin - administration & dosage Bone Density Conservation Agents - administration & dosage Calcium, Dietary - administration & dosage Carcinogens - toxicity Diet Disease Models, Animal Lung Neoplasms - chemically induced Lung Neoplasms - pathology Lung Neoplasms - prevention & control Mice Mice, Inbred A Vitamin D - administration & dosage |
| title | Chemoprevention with acetylsalicylic acid, vitamin D and calcium reduces risk of carcinogen-induced lung tumors |
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