Secretory lysosomes of mouse mast cells store and exocytose active caspase‐3 in a strictly granzyme B dependent manner

In this study, we report that cytoplasmic granules from in vivo and in vitro derived mouse mast cells (MCs) contain active granzyme B (gzmB) and caspase‐3, which is consistent with recent findings. Studying WT and gzmB‐deficient mice, we observed that BM‐derived MCs (BMMCs) from both strains contain...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	European journal of immunology 2013-12, Vol.43 (12), p.3209-3218
Hauptverfasser:	Zorn, Carolin N., Pardo, Julian, Martin, Praxedis, Kuhny, Marcel, Simon, Markus M., Huber, Michael
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity - physiology Animals Antigens - immunology Bone Marrow Cells - cytology Bone Marrow Cells - enzymology Bone Marrow Cells - immunology Caspase 3 - biosynthesis Caspase 3 - genetics Caspase 3 - immunology Caspase‐3 CD8-Positive T-Lymphocytes - cytology CD8-Positive T-Lymphocytes - enzymology CD8-Positive T-Lymphocytes - immunology Cell Line Cytotoxic T lymphocytes Effector function Exocytosis - genetics Exocytosis - immunology Gene Expression Regulation, Enzymologic - genetics Gene Expression Regulation, Enzymologic - immunology Granzyme B Granzymes - biosynthesis Granzymes - genetics Granzymes - immunology Immunity, Innate - physiology Inflammation Interleukin-33 Interleukins - genetics Interleukins - immunology Interleukins - metabolism Lysosomes - enzymology Lysosomes - genetics Lysosomes - immunology Mast Cells - cytology Mast Cells - enzymology Mast Cells - immunology Mice Mice, Knockout Proteolysis Rodents
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!