RNA-Pareto: interactive analysis of Pareto-optimal RNA sequence-structure alignments
Incorporating secondary structure information into the alignment process improves the quality of RNA sequence alignments. Instead of using fixed weighting parameters, sequence and structure components can be treated as different objectives and optimized simultaneously. The result is not a single, bu...
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| Veröffentlicht in: | Bioinformatics 2013-12, Vol.29 (23), p.3102-3104 |
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| container_issue | 23 |
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| container_title | Bioinformatics |
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| creator | Schnattinger, Thomas Schöning, Uwe Marchfelder, Anita Kestler, Hans A |
| description | Incorporating secondary structure information into the alignment process improves the quality of RNA sequence alignments. Instead of using fixed weighting parameters, sequence and structure components can be treated as different objectives and optimized simultaneously. The result is not a single, but a Pareto-set of equally optimal solutions, which all represent different possible weighting parameters. We now provide the interactive graphical software tool RNA-Pareto, which allows a direct inspection of all feasible results to the pairwise RNA sequence-structure alignment problem and greatly facilitates the exploration of the optimal solution set. |
| doi_str_mv | 10.1093/bioinformatics/btt536 |
| format | Article |
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| identifier | ISSN: 1367-4803 |
| ispartof | Bioinformatics, 2013-12, Vol.29 (23), p.3102-3104 |
| issn | 1367-4803 1367-4811 1460-2059 |
| language | eng |
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| source | Oxford Journals Open Access Collection; MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Alma/SFX Local Collection |
| subjects | Algorithms Base Sequence Computational Biology - methods Molecular Sequence Data Nucleic Acid Conformation RNA - chemistry Sequence Alignment - methods Sequence Analysis, RNA - methods Sequence Homology, Nucleic Acid Software |
| title | RNA-Pareto: interactive analysis of Pareto-optimal RNA sequence-structure alignments |
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