Cell-Mediated Immunity in Human Pregnancy
The function of thymus‐dependent lymphocytes (T lymphocytes) was studied in women during pregnancy and labor and postpartum by evaluating the blastogenesis of peripheral lymphocytes, which were stimulated with phytohemagglutinin‐P (PHA‐P) in both whole‐blood semimicroculture and purified lymphocyte...
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| Veröffentlicht in: | Microbiology and immunology 1979-09, Vol.23 (9), p.899-907 |
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| container_title | Microbiology and immunology |
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| creator | Fujisaki, Syunichi Mori, Norimasa Sasaki, Toshio Maeyama, Masao |
| description | The function of thymus‐dependent lymphocytes (T lymphocytes) was studied in women during pregnancy and labor and postpartum by evaluating the blastogenesis of peripheral lymphocytes, which were stimulated with phytohemagglutinin‐P (PHA‐P) in both whole‐blood semimicroculture and purified lymphocyte culture. Data from 353 random samples (203 women) and 50 serial specimens from 10 women revealed that PHA‐P induced‐lymphocyte blastogenesis was significantly (p |
| doi_str_mv | 10.1111/j.1348-0421.1979.tb02823.x |
| format | Article |
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Data from 353 random samples (203 women) and 50 serial specimens from 10 women revealed that PHA‐P induced‐lymphocyte blastogenesis was significantly (p<0.005) reduced during pregnancy and labor but rapidly returned to normal several days after artificial termination in the early stage of pregnancy as well as after full‐term delivery. These results indicate that the T‐lymphocyte function in maternal peripheral blood is depressed by causes related to pregnancy. It seems very likely that depressed T‐lymphocyte function during pregnancy is caused by inhibitory factors in the blood plasma derived from the feto‐placental unit. Questions relating to the inhibitory factors in maternal plasma are discussed.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/j.1348-0421.1979.tb02823.x</identifier><language>eng</language><publisher>Blackwell Publishing Ltd</publisher><ispartof>Microbiology and immunology, 1979-09, Vol.23 (9), p.899-907</ispartof><rights>owned by Center for Academic Publications Japan (Publisher)</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2583-1b3319892768b5d2bb48ac6d0d1413fcf2188a613c294f421f1ab831dd2797603</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27923,27924</link.rule.ids></links><search><creatorcontrib>Fujisaki, Syunichi</creatorcontrib><creatorcontrib>Mori, Norimasa</creatorcontrib><creatorcontrib>Sasaki, Toshio</creatorcontrib><creatorcontrib>Maeyama, Masao</creatorcontrib><title>Cell-Mediated Immunity in Human Pregnancy</title><title>Microbiology and immunology</title><addtitle>Microbiology and Immunology</addtitle><description>The function of thymus‐dependent lymphocytes (T lymphocytes) was studied in women during pregnancy and labor and postpartum by evaluating the blastogenesis of peripheral lymphocytes, which were stimulated with phytohemagglutinin‐P (PHA‐P) in both whole‐blood semimicroculture and purified lymphocyte culture. Data from 353 random samples (203 women) and 50 serial specimens from 10 women revealed that PHA‐P induced‐lymphocyte blastogenesis was significantly (p<0.005) reduced during pregnancy and labor but rapidly returned to normal several days after artificial termination in the early stage of pregnancy as well as after full‐term delivery. These results indicate that the T‐lymphocyte function in maternal peripheral blood is depressed by causes related to pregnancy. It seems very likely that depressed T‐lymphocyte function during pregnancy is caused by inhibitory factors in the blood plasma derived from the feto‐placental unit. 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Data from 353 random samples (203 women) and 50 serial specimens from 10 women revealed that PHA‐P induced‐lymphocyte blastogenesis was significantly (p<0.005) reduced during pregnancy and labor but rapidly returned to normal several days after artificial termination in the early stage of pregnancy as well as after full‐term delivery. These results indicate that the T‐lymphocyte function in maternal peripheral blood is depressed by causes related to pregnancy. It seems very likely that depressed T‐lymphocyte function during pregnancy is caused by inhibitory factors in the blood plasma derived from the feto‐placental unit. Questions relating to the inhibitory factors in maternal plasma are discussed.</abstract><pub>Blackwell Publishing Ltd</pub><doi>10.1111/j.1348-0421.1979.tb02823.x</doi><tpages>9</tpages></addata></record> |
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| identifier | ISSN: 0385-5600 |
| ispartof | Microbiology and immunology, 1979-09, Vol.23 (9), p.899-907 |
| issn | 0385-5600 1348-0421 |
| language | eng |
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| source | J-STAGE Free; Freely Accessible Japanese Titles; Alma/SFX Local Collection |
| title | Cell-Mediated Immunity in Human Pregnancy |
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