Stearylated Antimicrobial Peptide Melittin and Its Retro Isomer for Efficient Gene Transfection

A crucial bottleneck in nonviral vector-mediated gene delivery is poor endosomal escape. Here, we constructed novel gene vectors by coupling the stearyl moiety to the N-terminus of the antimicrobial peptide melittin (stearyl-Mel) and its retro isomer (stearyl-rMel) due to their high membrane-lytic a...

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Veröffentlicht in:	Bioconjugate chemistry 2013-11, Vol.24 (11), p.1805-1812
Hauptverfasser:	Zhang, Wei, Song, Jingjing, Liang, Ranran, Zheng, Xin, Chen, Jianbo, Li, Guolin, Zhang, Bangzhi, Yan, Xiang, Wang, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Antimicrobial Cationic Peptides - chemistry Antimicrobial Cationic Peptides - metabolism Antimicrobial Cationic Peptides - pharmacology Antimicrobial peptides Antineoplastic Agents - chemistry Antineoplastic Agents - metabolism Antineoplastic Agents - pharmacology Cell Proliferation - drug effects Cells, Cultured Cercopithecus aethiops CHO Cells COS Cells Cricetulus Dose-Response Relationship, Drug Drug Screening Assays, Antitumor Gene Transfer Techniques Genetic Vectors - chemistry Genetic Vectors - metabolism Genetic Vectors - pharmacology Humans Melitten - chemistry Melitten - metabolism Melitten - pharmacology Membranes Molecular Structure Peptides Plasmids Stearic Acids - chemistry Stearic Acids - metabolism Stearic Acids - pharmacology Stereoisomerism Structure-Activity Relationship Transfection Tumors
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