Disruption of CDH2/N-Cadherin–Based Adherens Junctions Leads to Apoptosis of Ependymal Cells and Denudation of Brain Ventricular Walls

ABSTRACTDisruption/denudation of the ependymal lining has been associated with the pathogenesis of various human CNS disorders, including hydrocephalus, spina bifida aperta, and periventricular heterotopia. It has been traditionally considered that ependymal denudation is a consequence of mechanical...

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Veröffentlicht in:	Journal of neuropathology and experimental neurology 2013-09, Vol.72 (9), p.846-860
Hauptverfasser:	Oliver, Cristian, González, César A., Alvial, Genaro, Flores, Carlos A., Rodríguez, Esteban M., Bátiz, Luis Federico
Format:	Artikel
Sprache:	eng
Schlagworte:	Adherens Junctions - drug effects Adherens Junctions - metabolism Amino acids Analysis of Variance Animals Antibodies - pharmacology Antigens, CD - chemistry Antigens, CD - immunology Antigens, CD - metabolism Apoptosis Apoptosis - drug effects Apoptosis - physiology Brain - cytology Cadherins - chemistry Cadherins - immunology Cadherins - metabolism Cattle Cytoskeleton Dose-Response Relationship, Drug Electric Impedance Electrophysiological Phenomena - drug effects Ependyma - cytology Ependyma - metabolism Ependyma - ultrastructure Fetuses Glial Fibrillary Acidic Protein - metabolism Humans In Situ Nick-End Labeling Microscopy, Electron, Transmission Neuropathology Organ Culture Techniques Peptide Hydrolases - immunology Peptides Studies Subcellular Fractions - metabolism Subcellular Fractions - ultrastructure Time Factors
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