Altered Brain Uptake of Therapeutics in a Triple Transgenic Mouse Model of Alzheimer’s Disease

ABSTRACT Purpose The purpose of this study was to systematically assess the impact of Alzheimer’s disease (AD)-associated blood–brain barrier (BBB) alterations on the uptake of therapeutics into the brain. Methods The brain uptake of probe compounds was measured in 18–20 month old wild type (WT) and...

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Veröffentlicht in:	Pharmaceutical research 2013-11, Vol.30 (11), p.2868-2879
Hauptverfasser:	Mehta, Dharmini C., Short, Jennifer L., Nicolazzo, Joseph A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult and adolescent clinical studies Alzheimer Disease - genetics Alzheimer Disease - pathology Alzheimer's disease Animals ATP-Binding Cassette, Sub-Family B, Member 1 - analysis ATP-Binding Cassette, Sub-Family B, Member 1 - metabolism Biochemistry Biological and medical sciences Biological Transport Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Blood-brain barrier Brain - blood supply Brain - metabolism Brain - pathology Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Digoxin - pharmacokinetics Disease Models, Animal Glycoproteins Humans Medical Law Medical sciences Mice Mice, Transgenic Neurology Organic mental disorders. Neuropsychology Pharmacokinetics Pharmacology Pharmacology. Drug treatments Pharmacology/Toxicology Pharmacy Propranolol - pharmacokinetics Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Research Paper Sucrose - pharmacokinetics Transgenes Vasodilator Agents - pharmacokinetics Verapamil - pharmacokinetics
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