The effect of posterior tooth loss on the expression of type II collagen, IL-1[beta] and VEGF in the condylar cartilage of growing rats

The effect of posterior tooth loss on the expression of type II collagen, IL-1[beta] and VEGF in the condylar cartilage of growing rats

Objective: The aim of this study was to evaluate the effect of unilateral and bilateral loss of posterior occlusal support on the expression of type II collagen, interleukin-1[beta] and VEGF in the condylar cartilage of growing rats. Design: Thirty female Wistar rats (5 weeks old) were randomized in...

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Veröffentlicht in:Archives of oral biology 2012-11, Vol.57 (11), p.1551-1557
Hauptverfasser: Farias-Neto, Arcelino, Martins, Ana Paula Varela Brown, Sanchez-Ayala, Alfonso, Rabie, Abou Bakr Mahmoud, Novaes, Pedro Duarte, Rizzatti-Barbosa, Celia Marisa
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Cartilage
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container_end_page 1557
container_issue 11
container_start_page 1551
container_title Archives of oral biology
container_volume 57
creator Farias-Neto, Arcelino
Martins, Ana Paula Varela Brown
Sanchez-Ayala, Alfonso
Rabie, Abou Bakr Mahmoud
Novaes, Pedro Duarte
Rizzatti-Barbosa, Celia Marisa
description Objective: The aim of this study was to evaluate the effect of unilateral and bilateral loss of posterior occlusal support on the expression of type II collagen, interleukin-1[beta] and VEGF in the condylar cartilage of growing rats. Design: Thirty female Wistar rats (5 weeks old) were randomized into three groups: control, unilateral extraction of mandibular molar teeth, bilateral extraction of mandibular molar teeth. Animals were sacrificed 8 weeks after tooth extraction and the temporomandibular joints were prepared for immunohistochemical analysis. Results: Bilateral molar extraction increased the expression of interleukin-1[beta] (P < 0.01) and VEGF (P < 0.01), while unilateral extraction increased the expression of interleukin-1[beta] (P < 0.05) and type II collagen (P < 0.01). The expression of VEGF was higher on the extracted than on the non-extracted side (P < 0.01) after unilateral extraction. Conclusions: Loss of posterior occlusal support alters the expression of type II collagen, interleukin-1[beta] and VEGF in the condylar cartilage of rats. The expression pattern of these proteins is different when loss of occlusal support was bilateral or unilateral, including differences between extracted and non-extracted sides.
doi_str_mv 10.1016/j.archoralbio.2012.05.002
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Design: Thirty female Wistar rats (5 weeks old) were randomized into three groups: control, unilateral extraction of mandibular molar teeth, bilateral extraction of mandibular molar teeth. Animals were sacrificed 8 weeks after tooth extraction and the temporomandibular joints were prepared for immunohistochemical analysis. Results: Bilateral molar extraction increased the expression of interleukin-1[beta] (P &lt; 0.01) and VEGF (P &lt; 0.01), while unilateral extraction increased the expression of interleukin-1[beta] (P &lt; 0.05) and type II collagen (P &lt; 0.01). The expression of VEGF was higher on the extracted than on the non-extracted side (P &lt; 0.01) after unilateral extraction. Conclusions: Loss of posterior occlusal support alters the expression of type II collagen, interleukin-1[beta] and VEGF in the condylar cartilage of rats. 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Design: Thirty female Wistar rats (5 weeks old) were randomized into three groups: control, unilateral extraction of mandibular molar teeth, bilateral extraction of mandibular molar teeth. Animals were sacrificed 8 weeks after tooth extraction and the temporomandibular joints were prepared for immunohistochemical analysis. Results: Bilateral molar extraction increased the expression of interleukin-1[beta] (P &lt; 0.01) and VEGF (P &lt; 0.01), while unilateral extraction increased the expression of interleukin-1[beta] (P &lt; 0.05) and type II collagen (P &lt; 0.01). The expression of VEGF was higher on the extracted than on the non-extracted side (P &lt; 0.01) after unilateral extraction. Conclusions: Loss of posterior occlusal support alters the expression of type II collagen, interleukin-1[beta] and VEGF in the condylar cartilage of rats. 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title The effect of posterior tooth loss on the expression of type II collagen, IL-1[beta] and VEGF in the condylar cartilage of growing rats
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