Cortical grey matter demyelination can be induced by elevated pro-inflammatory cytokines in the subarachnoid space of MOG-immunized rats

A substantial proportion of cases with secondary progressive multiple sclerosis have extensive inflammation in the leptomeninges that is associated with increased subpial demyelination, neuronal loss and an exacerbated disease course. However, the mechanisms underlying this extensive subpial patholo...

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Veröffentlicht in:	Brain (London, England : 1878) England : 1878), 2013-12, Vol.136 (Pt 12), p.3596-3608
Hauptverfasser:	GARDNER, Christopher, MAGLIOZZI, Roberta, DURRENBERGER, Pascal F, HOWELL, Owain W, RUNDLE, Jon, REYNOLDS, Richard
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Animals Biological and medical sciences Brain - metabolism Cerebral Cortex - metabolism Cerebral Cortex - pathology Cytokines - genetics Cytokines - metabolism Cytokines - pharmacology Disease Models, Animal Dose-Response Relationship, Drug Drug toxicity and drugs side effects treatment Encephalomyelitis, Autoimmune, Experimental - chemically induced Encephalomyelitis, Autoimmune, Experimental - complications Encephalomyelitis, Autoimmune, Experimental - immunology Female Humans Male Medical sciences Microglia - drug effects Microglia - metabolism Microglia - pathology Middle Aged Multiple Sclerosis - cerebrospinal fluid Multiple Sclerosis - pathology Multiple sclerosis and variants. Guillain barré syndrome and other inflammatory polyneuropathies. Leukoencephalitis Myelin-Oligodendrocyte Glycoprotein - immunology Myelin-Oligodendrocyte Glycoprotein - metabolism Myelin-Oligodendrocyte Glycoprotein - toxicity Neurology Neurons - drug effects Neurons - physiology Pharmacology. Drug treatments Postmortem Changes Rats Subarachnoid Space - drug effects Subarachnoid Space - metabolism Toxicity: nervous system and muscle
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