Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: An integrated meta-analysis
DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The −3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We pe...
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| Veröffentlicht in: | American journal of medical genetics. Part B, Neuropsychiatric genetics Neuropsychiatric genetics, 2012-12, Vol.159B (8), p.970-976 |
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| container_title | American journal of medical genetics. Part B, Neuropsychiatric genetics |
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| creator | Zou, Li Chen, Wei Shao, Shanshan Sun, Zhao Zhong, Rong Shi, Junxin Miao, Xiaoping Song, Ranran |
| description | DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The −3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta‐analysis integrating case–control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case–control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta‐analysis, the pooled OR for the −3A allele and the 931T allele was 0.68 (95% CI = 0.25–1.87, Pheterogeneity = 0.000) and 0.87 (95% CI = 0.78–0.98, Pheterogeneity = 0.125), respectively. The stratified analysis showed that the between‐study heterogeneity regarding the −3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of −3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the −3G > A in DYX1C1, was significantly associated with the risk of dyslexia. © 2012 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/ajmg.b.32102 |
| format | Article |
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The −3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta‐analysis integrating case–control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case–control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta‐analysis, the pooled OR for the −3A allele and the 931T allele was 0.68 (95% CI = 0.25–1.87, Pheterogeneity = 0.000) and 0.87 (95% CI = 0.78–0.98, Pheterogeneity = 0.125), respectively. The stratified analysis showed that the between‐study heterogeneity regarding the −3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of −3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the −3G > A in DYX1C1, was significantly associated with the risk of dyslexia. © 2012 Wiley Periodicals, Inc.</description><identifier>ISSN: 1552-4841</identifier><identifier>EISSN: 1552-485X</identifier><identifier>DOI: 10.1002/ajmg.b.32102</identifier><identifier>PMID: 23065966</identifier><language>eng</language><publisher>Hoboken: Wiley Subscription Services, Inc., A Wiley Company</publisher><subject>Axonogenesis ; Biological and medical sciences ; Case-Control Studies ; Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. 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Part B, Neuropsychiatric genetics, 2012-12, Vol.159B (8), p.970-976</ispartof><rights>Copyright © 2012 Wiley Periodicals, Inc.</rights><rights>2014 INIST-CNRS</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4642-d00da090a9007a35f8ec0dea7d3eeea467765099094ae7c92f015f3819c9a0a33</citedby><cites>FETCH-LOGICAL-c4642-d00da090a9007a35f8ec0dea7d3eeea467765099094ae7c92f015f3819c9a0a33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fajmg.b.32102$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fajmg.b.32102$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26635465$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23065966$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zou, Li</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Shao, Shanshan</creatorcontrib><creatorcontrib>Sun, Zhao</creatorcontrib><creatorcontrib>Zhong, Rong</creatorcontrib><creatorcontrib>Shi, Junxin</creatorcontrib><creatorcontrib>Miao, Xiaoping</creatorcontrib><creatorcontrib>Song, Ranran</creatorcontrib><title>Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: An integrated meta-analysis</title><title>American journal of medical genetics. Part B, Neuropsychiatric genetics</title><addtitle>Am. J. Med. Genet</addtitle><description>DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The −3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta‐analysis integrating case–control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case–control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta‐analysis, the pooled OR for the −3A allele and the 931T allele was 0.68 (95% CI = 0.25–1.87, Pheterogeneity = 0.000) and 0.87 (95% CI = 0.78–0.98, Pheterogeneity = 0.125), respectively. The stratified analysis showed that the between‐study heterogeneity regarding the −3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of −3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the −3G > A in DYX1C1, was significantly associated with the risk of dyslexia. © 2012 Wiley Periodicals, Inc.</description><subject>Axonogenesis</subject><subject>Biological and medical sciences</subject><subject>Case-Control Studies</subject><subject>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</subject><subject>dyslexia</subject><subject>Dyslexia - genetics</subject><subject>DYX1C1</subject><subject>Genetic Association Studies</subject><subject>Genetic Predisposition to Disease</subject><subject>Genetics</subject><subject>Humans</subject><subject>KIAA0319</subject><subject>Medical genetics</subject><subject>Medical sciences</subject><subject>meta-analysis</subject><subject>Nerve Tissue Proteins - genetics</subject><subject>Nervous system (semeiology, syndromes)</subject><subject>Neurology</subject><subject>Nuclear Proteins - genetics</subject><subject>Polymorphism, Single Nucleotide</subject><subject>susceptibility</subject><issn>1552-4841</issn><issn>1552-485X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2012</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqF0cuP0zAQB-AIgdgH3DgjSwhpD00Z27Edc4sKlF0WEBKPcrKmjrO4mybFTtjtf0_62CJxgJMt65sZjX9J8oTCmAKwF7hYXo3nY84osHvJMRWCpVkuZvcP94weJScxLgA4CKUeJkeMgxRayuNkNXWN67wlvzB4bDriG_LuvCiAUz0i874jTbt9fPV9Rid0RHwkGGNrPXauJDe--0GCj9ekrUi5jrW79fiSFM1Q0rmrsEVL12GKDdbr6OOj5EGFdXSP9-dp8uXN68-Tt-nlx-n5pLhMbSYzlpYAJYIG1AAKuahyZ6F0qErunMNMKiUFaA06Q6esZhVQUfGcaqsRkPPT5GzXdxXan72LnVn6aF1dY-PaPhqaaSYZH37q_5QKClwBpQN99hddtH0YVts0lDmA5jkb1GinbGhjDK4yq-CXGNaGgtmEZjahmbnZhjbwp_um_XzpygO-S2kAz_cAo8W6CthYH_-4gYhMbhbhO3fja7f-51BTXLyf3o1Pd1U-du72UIXh2kjFlTDfPkzN5FN-kX_NZoby35uOu1Q</recordid><startdate>201212</startdate><enddate>201212</enddate><creator>Zou, Li</creator><creator>Chen, Wei</creator><creator>Shao, Shanshan</creator><creator>Sun, Zhao</creator><creator>Zhong, Rong</creator><creator>Shi, Junxin</creator><creator>Miao, Xiaoping</creator><creator>Song, Ranran</creator><general>Wiley Subscription Services, Inc., A Wiley Company</general><general>Wiley-Liss</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TK</scope><scope>8FD</scope><scope>FR3</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201212</creationdate><title>Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: An integrated meta-analysis</title><author>Zou, Li ; Chen, Wei ; Shao, Shanshan ; Sun, Zhao ; Zhong, Rong ; Shi, Junxin ; Miao, Xiaoping ; Song, Ranran</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4642-d00da090a9007a35f8ec0dea7d3eeea467765099094ae7c92f015f3819c9a0a33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2012</creationdate><topic>Axonogenesis</topic><topic>Biological and medical sciences</topic><topic>Case-Control Studies</topic><topic>Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes</topic><topic>dyslexia</topic><topic>Dyslexia - genetics</topic><topic>DYX1C1</topic><topic>Genetic Association Studies</topic><topic>Genetic Predisposition to Disease</topic><topic>Genetics</topic><topic>Humans</topic><topic>KIAA0319</topic><topic>Medical genetics</topic><topic>Medical sciences</topic><topic>meta-analysis</topic><topic>Nerve Tissue Proteins - genetics</topic><topic>Nervous system (semeiology, syndromes)</topic><topic>Neurology</topic><topic>Nuclear Proteins - genetics</topic><topic>Polymorphism, Single Nucleotide</topic><topic>susceptibility</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zou, Li</creatorcontrib><creatorcontrib>Chen, Wei</creatorcontrib><creatorcontrib>Shao, Shanshan</creatorcontrib><creatorcontrib>Sun, Zhao</creatorcontrib><creatorcontrib>Zhong, Rong</creatorcontrib><creatorcontrib>Shi, Junxin</creatorcontrib><creatorcontrib>Miao, Xiaoping</creatorcontrib><creatorcontrib>Song, Ranran</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Neurosciences Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zou, Li</au><au>Chen, Wei</au><au>Shao, Shanshan</au><au>Sun, Zhao</au><au>Zhong, Rong</au><au>Shi, Junxin</au><au>Miao, Xiaoping</au><au>Song, Ranran</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: An integrated meta-analysis</atitle><jtitle>American journal of medical genetics. Part B, Neuropsychiatric genetics</jtitle><addtitle>Am. J. Med. Genet</addtitle><date>2012-12</date><risdate>2012</risdate><volume>159B</volume><issue>8</issue><spage>970</spage><epage>976</epage><pages>970-976</pages><issn>1552-4841</issn><eissn>1552-485X</eissn><abstract>DYX1C1 and KIAA0319 have been two of the most extensively studied candidate genes for dyslexia given their important roles in the neuronal migration and neurite growth. The −3G > A in DYX1C1 and the 931C > T in KIAA0319 were of special interest for dyslexia but with inconsistent results. We performed a meta‐analysis integrating case–control and transmission/disequilibrium test (TDT) studies to clearly discern the effect of these two variants in dyslexia. Data from case–control and TDT studies were analyzed in an allelic model using the Catmap software. In overall meta‐analysis, the pooled OR for the −3A allele and the 931T allele was 0.68 (95% CI = 0.25–1.87, Pheterogeneity = 0.000) and 0.87 (95% CI = 0.78–0.98, Pheterogeneity = 0.125), respectively. The stratified analysis showed that the between‐study heterogeneity regarding the −3G > A polymorphism might be accounted by the publication year. Additionally, the sensitivity analysis of −3G > A polymorphism indicated the stability of the result. In conclusion, our results suggested that the 931C > T variant in KIAA0319, but not the −3G > A in DYX1C1, was significantly associated with the risk of dyslexia. © 2012 Wiley Periodicals, Inc.</abstract><cop>Hoboken</cop><pub>Wiley Subscription Services, Inc., A Wiley Company</pub><pmid>23065966</pmid><doi>10.1002/ajmg.b.32102</doi><tpages>7</tpages></addata></record> |
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| subjects | Axonogenesis Biological and medical sciences Case-Control Studies Disorders of higher nervous function. Focal brain diseases. Central vestibular syndrome and deafness. Brain stem syndromes dyslexia Dyslexia - genetics DYX1C1 Genetic Association Studies Genetic Predisposition to Disease Genetics Humans KIAA0319 Medical genetics Medical sciences meta-analysis Nerve Tissue Proteins - genetics Nervous system (semeiology, syndromes) Neurology Nuclear Proteins - genetics Polymorphism, Single Nucleotide susceptibility |
| title | Genetic variant in KIAA0319, but not in DYX1C1, is associated with risk of dyslexia: An integrated meta-analysis |
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