The impact of T-cell depletion techniques on the outcome after haploidentical hematopoietic SCT

Several T-cell depletion (TCD) techniques are used for haploidentical hematopoietic SCT (HSCT), but direct comparisons are rare. We therefore studied the effect of in vitro TCD with graft engineering (CD34 selection or CD3/CD19 depletion, 74%) or in vivo TCD using alemtuzumab (26%) on outcome, immun...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2014-01, Vol.49 (1), p.55-61
Hauptverfasser:	Marek, A, Stern, M, Chalandon, Y, Ansari, M, Ozsahin, H, Güngör, T, Gerber, B, Kühne, T, Passweg, J R, Gratwohl, A, Tichelli, A, Seger, R, Schanz, U, Halter, J, Stussi, G
Format:	Artikel
Sprache:	eng
Schlagworte:	631/1647/664 631/250/1904 631/250/254 Adolescent Adsorption Adult Alemtuzumab Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antibodies, Monoclonal, Humanized - therapeutic use Antigens, CD19 - metabolism Antigens, CD34 - metabolism Antineoplastic Agents - therapeutic use Biological and medical sciences Bone marrow Bone marrow, stem cells transplantation. Graft versus host reaction CD3 Complex - metabolism Cell Biology Child Child, Preschool Cytomegalovirus Cytomegalovirus infections Female Graft vs Host Disease Health aspects Hematologic Neoplasms - therapy Hematology Hematopoietic Stem Cell Mobilization Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Infant Infant, Newborn Internal Medicine Lymphocyte Depletion - methods Male Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Methods Middle Aged Neutrophils - cytology original-article Physiological aspects Properties Public Health Recurrence Retrospective Studies Risk factors Stem cell transplantation Stem Cells Switzerland T cells T-Lymphocytes - immunology Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning Treatment Outcome Young Adult
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