The impact of CD34+ cell dose on engraftment after SCTs: personalized estimates based on mathematical modeling

It is known that the number of transplanted cells has a significant impact on the outcome after SCT. We identify issues that cannot be addressed by conventional analysis of clinical trials and ask whether it is possible to develop a refined analysis to conclude about the outcome of individual patien...

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Veröffentlicht in:	Bone marrow transplantation (Basingstoke) 2014-01, Vol.49 (1), p.30-37
Hauptverfasser:	Stiehl, T, Ho, A D, Marciniak-Czochra, A
Format:	Artikel
Sprache:	eng
Schlagworte:	631/114/2397 631/250/1904 631/61/51/1844 Adolescent Adult Aged Algorithms Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antigens, CD34 - metabolism Biological and medical sciences Bone marrow Bone marrow transplantation Bone marrow, stem cells transplantation. Graft versus host reaction Cell Biology Child Child, Preschool Clinical trials Clinical Trials as Topic Computer Simulation Cytokines - metabolism Hematology Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Infant Internal Medicine Mathematical models Medical research Medical sciences Medicine Medicine & Public Health Medicine, Experimental Middle Aged Models, Theoretical Neutrophils - cytology original-article Public Health Reproducibility of Results Stem cell transplantation Stem Cells Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - methods Young Adult
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