Human endogenous retrovirus type W envelope protein inhibits oligodendroglial precursor cell differentiation

Objective Differentiation of oligodendroglial precursor cells is crucial for central nervous system remyelination and is influenced by both extrinsic and intrinsic factors. Recent studies showed that human endogenous retrovirus type W (HERV‐W) contributes significantly to brain damage. In particular...

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Veröffentlicht in:	Annals of neurology 2013-11, Vol.74 (5), p.721-732
Hauptverfasser:	Kremer, David, Schichel, Tanja, Förster, Moritz, Tzekova, Nevena, Bernard, Corinne, van der Valk, Paul, van Horssen, Jack, Hartung, Hans-Peter, Perron, Hervé, Küry, Patrick
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cell Differentiation Cells, Cultured Gene expression Gene Products, env - genetics Gene Products, env - metabolism Human endogenous retrovirus Humans Medical research Myelin Sheath - genetics Myelin Sheath - metabolism Neural Stem Cells - cytology Neural Stem Cells - metabolism Oligodendroglia - cytology Oligodendroglia - metabolism Pregnancy Proteins - genetics Pregnancy Proteins - metabolism Proteins Rats Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism
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