Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma
Background More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indicatio...
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| Veröffentlicht in: | Annals of surgical oncology 2013-06, Vol.20 (6), p.1978-1984 |
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| container_end_page | 1984 |
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| container_issue | 6 |
| container_start_page | 1978 |
| container_title | Annals of surgical oncology |
| container_volume | 20 |
| creator | Motoyama, Satoru Mori, Kazuhiko Kamei, Takashi Miura, Masatomo Hinai, Yudai Sato, Yusuke Yoshino, Kei Sasaki, Tomohiko Miyata, Go Seto, Yasuyuki Ogawa, Jun-ichi |
| description | Background
More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will require more accurate and individualized evaluation of lymph node metastasis.
Methods
The study participants were 121 esophageal cancer patients who underwent curative surgery for thoracic submucosal ESCC at three Japanese hospitals. DNA was extracted from blood samples, and the C-reactive protein (CRP) 1846C>T genetic polymorphism (rs1205) was investigated using polymerase chain reaction-restriction fragment length polymorphism. We then evaluated the value of CRP 1846C>T polymorphism for diagnosis of lymph node metastasis.
Results
Forty-nine (40 %) patients had lymph node metastasis. The CRP 1846 C/T genotype was C/C in 19 patients, C/T in 57 patients, and T/T in 45 patients. Fisher’s exact analysis of the CRP 1846C>T polymorphism showed a significantly higher frequency of lymph node involvement with the T/T genotype. Univariate and multivariate logistic regression models revealed that patients carrying the 1846 T/T genotype had a significantly greater likelihood of developing lymph node metastasis (odds ratio >2.6). Combining the CRP 1846 C/T genotype with clinical diagnosis, mainly using CT, brought a negative predictive value of 80 % to diagnosing lymph node involvement.
Conclusions
CRP genetic polymorphism may be a novel predictor of risk of lymph node metastasis in ESCC, which could enable better evaluation of the necessity for lymph node dissection. |
| doi_str_mv | 10.1245/s10434-012-2765-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492621983</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1353043193</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-e3d4c6d38825194d8ac7452ee4ccd8734b3089aa15e7527099c22f595bd6664c3</originalsourceid><addsrcrecordid>eNqFkd1qFDEUgINY7I8-gDcS8Mab0fzP5EaQYa3CWku7vQ7ZTHYndWYyTWaEfQsfuWe7VUSQQiDh5DsnJ-dD6DUl7ykT8kOmRHBREMoKVipZ6GfohEqICFXR53Amqio0U_IYneZ8SwgtOZEv0DHjjEKGOEG_Fj9tN9spxAHHDZ5aj69C_rE_L3f92OKL2Hj8zU82wwoZ3-QwbHF9dYlpJVT9cYXP_eCn4PBl7HZ9TGMbco_DgK_ndT-7mG2HV21M1gGzyHFs7dZD7Pputn2cM6591-HaJheG2NuX6Ghju-xfPe5n6ObzYlV_KZbfz7_Wn5aFE0ROheeNcKrhVcUk1aKprCuFZN4L55qq5GLNSaWtpdKXkpVEa8fYRmq5bpRSwvEz9O5Qd0zxbvZ5Mn3IDlqxg4euDBUwOEZ1xZ9GueQgguo9-vYf9DbOaYCPPFAleGEEKHqgXIo5J78xYwq9TTtDidmbNQezBsyavVmjIefNY2UYq2_-ZPxWCQA7ABmuhq1Pfz3936r3eiispA</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1353768120</pqid></control><display><type>article</type><title>Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma</title><source>MEDLINE</source><source>SpringerLink Journals - AutoHoldings</source><creator>Motoyama, Satoru ; Mori, Kazuhiko ; Kamei, Takashi ; Miura, Masatomo ; Hinai, Yudai ; Sato, Yusuke ; Yoshino, Kei ; Sasaki, Tomohiko ; Miyata, Go ; Seto, Yasuyuki ; Ogawa, Jun-ichi</creator><creatorcontrib>Motoyama, Satoru ; Mori, Kazuhiko ; Kamei, Takashi ; Miura, Masatomo ; Hinai, Yudai ; Sato, Yusuke ; Yoshino, Kei ; Sasaki, Tomohiko ; Miyata, Go ; Seto, Yasuyuki ; Ogawa, Jun-ichi</creatorcontrib><description>Background
More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will require more accurate and individualized evaluation of lymph node metastasis.
Methods
The study participants were 121 esophageal cancer patients who underwent curative surgery for thoracic submucosal ESCC at three Japanese hospitals. DNA was extracted from blood samples, and the C-reactive protein (CRP) 1846C>T genetic polymorphism (rs1205) was investigated using polymerase chain reaction-restriction fragment length polymorphism. We then evaluated the value of CRP 1846C>T polymorphism for diagnosis of lymph node metastasis.
Results
Forty-nine (40 %) patients had lymph node metastasis. The CRP 1846 C/T genotype was C/C in 19 patients, C/T in 57 patients, and T/T in 45 patients. Fisher’s exact analysis of the CRP 1846C>T polymorphism showed a significantly higher frequency of lymph node involvement with the T/T genotype. Univariate and multivariate logistic regression models revealed that patients carrying the 1846 T/T genotype had a significantly greater likelihood of developing lymph node metastasis (odds ratio >2.6). Combining the CRP 1846 C/T genotype with clinical diagnosis, mainly using CT, brought a negative predictive value of 80 % to diagnosing lymph node involvement.
Conclusions
CRP genetic polymorphism may be a novel predictor of risk of lymph node metastasis in ESCC, which could enable better evaluation of the necessity for lymph node dissection.</description><identifier>ISSN: 1068-9265</identifier><identifier>EISSN: 1534-4681</identifier><identifier>DOI: 10.1245/s10434-012-2765-9</identifier><identifier>PMID: 23212764</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Aged ; Biomarkers, Tumor - genetics ; C-Reactive Protein - genetics ; Carcinoma, Squamous Cell - diagnosis ; Carcinoma, Squamous Cell - genetics ; Carcinoma, Squamous Cell - secondary ; Carcinoma, Squamous Cell - surgery ; Esophageal Neoplasms - genetics ; Esophageal Neoplasms - pathology ; Esophageal Neoplasms - surgery ; Female ; Gastrointestinal Oncology ; Genotype ; Humans ; Kaplan-Meier Estimate ; Logistic Models ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Odds Ratio ; Oncology ; Polymorphism, Single Nucleotide ; Predictive Value of Tests ; Risk Factors ; Surgery ; Surgical Oncology</subject><ispartof>Annals of surgical oncology, 2013-06, Vol.20 (6), p.1978-1984</ispartof><rights>Society of Surgical Oncology 2012</rights><rights>Society of Surgical Oncology 2013</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-e3d4c6d38825194d8ac7452ee4ccd8734b3089aa15e7527099c22f595bd6664c3</citedby><cites>FETCH-LOGICAL-c405t-e3d4c6d38825194d8ac7452ee4ccd8734b3089aa15e7527099c22f595bd6664c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1245/s10434-012-2765-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1245/s10434-012-2765-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23212764$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Motoyama, Satoru</creatorcontrib><creatorcontrib>Mori, Kazuhiko</creatorcontrib><creatorcontrib>Kamei, Takashi</creatorcontrib><creatorcontrib>Miura, Masatomo</creatorcontrib><creatorcontrib>Hinai, Yudai</creatorcontrib><creatorcontrib>Sato, Yusuke</creatorcontrib><creatorcontrib>Yoshino, Kei</creatorcontrib><creatorcontrib>Sasaki, Tomohiko</creatorcontrib><creatorcontrib>Miyata, Go</creatorcontrib><creatorcontrib>Seto, Yasuyuki</creatorcontrib><creatorcontrib>Ogawa, Jun-ichi</creatorcontrib><title>Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma</title><title>Annals of surgical oncology</title><addtitle>Ann Surg Oncol</addtitle><addtitle>Ann Surg Oncol</addtitle><description>Background
More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will require more accurate and individualized evaluation of lymph node metastasis.
Methods
The study participants were 121 esophageal cancer patients who underwent curative surgery for thoracic submucosal ESCC at three Japanese hospitals. DNA was extracted from blood samples, and the C-reactive protein (CRP) 1846C>T genetic polymorphism (rs1205) was investigated using polymerase chain reaction-restriction fragment length polymorphism. We then evaluated the value of CRP 1846C>T polymorphism for diagnosis of lymph node metastasis.
Results
Forty-nine (40 %) patients had lymph node metastasis. The CRP 1846 C/T genotype was C/C in 19 patients, C/T in 57 patients, and T/T in 45 patients. Fisher’s exact analysis of the CRP 1846C>T polymorphism showed a significantly higher frequency of lymph node involvement with the T/T genotype. Univariate and multivariate logistic regression models revealed that patients carrying the 1846 T/T genotype had a significantly greater likelihood of developing lymph node metastasis (odds ratio >2.6). Combining the CRP 1846 C/T genotype with clinical diagnosis, mainly using CT, brought a negative predictive value of 80 % to diagnosing lymph node involvement.
Conclusions
CRP genetic polymorphism may be a novel predictor of risk of lymph node metastasis in ESCC, which could enable better evaluation of the necessity for lymph node dissection.</description><subject>Aged</subject><subject>Biomarkers, Tumor - genetics</subject><subject>C-Reactive Protein - genetics</subject><subject>Carcinoma, Squamous Cell - diagnosis</subject><subject>Carcinoma, Squamous Cell - genetics</subject><subject>Carcinoma, Squamous Cell - secondary</subject><subject>Carcinoma, Squamous Cell - surgery</subject><subject>Esophageal Neoplasms - genetics</subject><subject>Esophageal Neoplasms - pathology</subject><subject>Esophageal Neoplasms - surgery</subject><subject>Female</subject><subject>Gastrointestinal Oncology</subject><subject>Genotype</subject><subject>Humans</subject><subject>Kaplan-Meier Estimate</subject><subject>Logistic Models</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Odds Ratio</subject><subject>Oncology</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Predictive Value of Tests</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Surgical Oncology</subject><issn>1068-9265</issn><issn>1534-4681</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkd1qFDEUgINY7I8-gDcS8Mab0fzP5EaQYa3CWku7vQ7ZTHYndWYyTWaEfQsfuWe7VUSQQiDh5DsnJ-dD6DUl7ykT8kOmRHBREMoKVipZ6GfohEqICFXR53Amqio0U_IYneZ8SwgtOZEv0DHjjEKGOEG_Fj9tN9spxAHHDZ5aj69C_rE_L3f92OKL2Hj8zU82wwoZ3-QwbHF9dYlpJVT9cYXP_eCn4PBl7HZ9TGMbco_DgK_ndT-7mG2HV21M1gGzyHFs7dZD7Pputn2cM6591-HaJheG2NuX6Ghju-xfPe5n6ObzYlV_KZbfz7_Wn5aFE0ROheeNcKrhVcUk1aKprCuFZN4L55qq5GLNSaWtpdKXkpVEa8fYRmq5bpRSwvEz9O5Qd0zxbvZ5Mn3IDlqxg4euDBUwOEZ1xZ9GueQgguo9-vYf9DbOaYCPPFAleGEEKHqgXIo5J78xYwq9TTtDidmbNQezBsyavVmjIefNY2UYq2_-ZPxWCQA7ABmuhq1Pfz3936r3eiispA</recordid><startdate>20130601</startdate><enddate>20130601</enddate><creator>Motoyama, Satoru</creator><creator>Mori, Kazuhiko</creator><creator>Kamei, Takashi</creator><creator>Miura, Masatomo</creator><creator>Hinai, Yudai</creator><creator>Sato, Yusuke</creator><creator>Yoshino, Kei</creator><creator>Sasaki, Tomohiko</creator><creator>Miyata, Go</creator><creator>Seto, Yasuyuki</creator><creator>Ogawa, Jun-ichi</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7TO</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>8FD</scope><scope>FR3</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20130601</creationdate><title>Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma</title><author>Motoyama, Satoru ; 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More than 40 % of patients with submucosal esophageal squamous cell carcinoma (ESCC) have lymph node metastasis. Furthermore, the potential presence of undetectable metastasis before treatment prompts surgeons to be aggressive with respect to lymph node dissection. Extending the indication for endoscopic resection, a minimally invasive treatment, to superficial ESCCs will require more accurate and individualized evaluation of lymph node metastasis.
Methods
The study participants were 121 esophageal cancer patients who underwent curative surgery for thoracic submucosal ESCC at three Japanese hospitals. DNA was extracted from blood samples, and the C-reactive protein (CRP) 1846C>T genetic polymorphism (rs1205) was investigated using polymerase chain reaction-restriction fragment length polymorphism. We then evaluated the value of CRP 1846C>T polymorphism for diagnosis of lymph node metastasis.
Results
Forty-nine (40 %) patients had lymph node metastasis. The CRP 1846 C/T genotype was C/C in 19 patients, C/T in 57 patients, and T/T in 45 patients. Fisher’s exact analysis of the CRP 1846C>T polymorphism showed a significantly higher frequency of lymph node involvement with the T/T genotype. Univariate and multivariate logistic regression models revealed that patients carrying the 1846 T/T genotype had a significantly greater likelihood of developing lymph node metastasis (odds ratio >2.6). Combining the CRP 1846 C/T genotype with clinical diagnosis, mainly using CT, brought a negative predictive value of 80 % to diagnosing lymph node involvement.
Conclusions
CRP genetic polymorphism may be a novel predictor of risk of lymph node metastasis in ESCC, which could enable better evaluation of the necessity for lymph node dissection.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23212764</pmid><doi>10.1245/s10434-012-2765-9</doi><tpages>7</tpages></addata></record> |
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| issn | 1068-9265 1534-4681 |
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| subjects | Aged Biomarkers, Tumor - genetics C-Reactive Protein - genetics Carcinoma, Squamous Cell - diagnosis Carcinoma, Squamous Cell - genetics Carcinoma, Squamous Cell - secondary Carcinoma, Squamous Cell - surgery Esophageal Neoplasms - genetics Esophageal Neoplasms - pathology Esophageal Neoplasms - surgery Female Gastrointestinal Oncology Genotype Humans Kaplan-Meier Estimate Logistic Models Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Odds Ratio Oncology Polymorphism, Single Nucleotide Predictive Value of Tests Risk Factors Surgery Surgical Oncology |
| title | Evaluation of the Risk of Lymph Node Metastasis Using CRP 1846C>T Genetic Polymorphism in Submucosal Thoracic Esophageal Squamous Cell Carcinoma |
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