Methylphenidate and impulsivity: a comparison of effects of methylphenidate enantiomers on delay discounting in rats

Rationale Current formulations of methylphenidate (MPH) used in treatment of attention-deficit/hyperactivity disorder (ADHD) result in significantly different bioavailability of MPH enantiomers. Daytrana ® , a dl -MPH transdermal patch system, produces higher levels of l -MPH than when dl -MPH is ad...

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Veröffentlicht in:	Psychopharmacology 2014, Vol.231 (1), p.191-198
Hauptverfasser:	Slezak, Jonathan M., Ricaurte, George A., Tallarida, Ronald J., Katz, Jonathan L.
Format:	Artikel
Sprache:	eng
Schlagworte:	Analysis of Variance Animals Area Under Curve Attention deficit hyperactivity disorder Bioavailability Biomedical and Life Sciences Biomedicine Central Nervous System Stimulants - chemistry Central Nervous System Stimulants - pharmacology Complications and side effects Conditioning, Operant - drug effects Data Interpretation, Statistical Dosage and administration Dose-Response Relationship, Drug Drug therapy Enantiomers Impulsive Behavior - psychology Male Methylphenidate Methylphenidate - chemistry Methylphenidate - pharmacology Methylphenidate hydrochloride Neurosciences Original Investigation Pharmacology/Toxicology Photic Stimulation Physiological aspects Properties Psychiatry Psychopharmacology Rats Rats, Sprague-Dawley Stereoisomerism Stimulants
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