Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus
ABSTRACT Since 1992, many neonates in neonatal intensive care units in Japan have been developing fever and systemic exanthema. Immunological analyses of neonates with these symptoms has revealed that the bacterial superantigen, toxic shock syndrome toxin‐1 (TSST‐1) is the cause. The name neonatal T...
Gespeichert in:
Veröffentlicht in: | Microbiology and immunology 2013-11, Vol.57 (11), p.737-745 |
---|---|
Hauptverfasser: | , , |
Format: | Artikel |
Sprache: | eng |
Schlagworte: | |
Online-Zugang: | Volltext |
Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
container_end_page | 745 |
---|---|
container_issue | 11 |
container_start_page | 737 |
container_title | Microbiology and immunology |
container_volume | 57 |
creator | Takahashi, Naoto Imanishi, Ken'ichi Uchiyama, Takehiko |
description | ABSTRACT
Since 1992, many neonates in neonatal intensive care units in Japan have been developing fever and systemic exanthema. Immunological analyses of neonates with these symptoms has revealed that the bacterial superantigen, toxic shock syndrome toxin‐1 (TSST‐1) is the cause. The name neonatal TSS‐like exanthematous disease (NTED) has been applied to this condition. The most striking clinical finding has been that none of the term neonates have developed shock or died of NTED. The timing of NTED epidemics has coincided with the spread of emerging TSST‐1‐producing methicillin‐resistant Staphylococcus aureus clones in Japan. The low frequency of pregnant women with positive anti‐TSST‐1 antibody titers could be one reason for the spread of NTED in Japan. Neonates have immune tolerance against TSST‐1 and may actively suppress the immune response to NTED with interleukin‐10. According to the T cell responses in infants or young children with diseases induced by TSST‐1, the pathophysiology of TSST‐1‐related diseases may be age‐dependent. The precise mechanism of anergy and deletion of specific T cells stimulated with TSST‐1 should be investigated in neonates infected with NTED. Both NTED and TSS might provide good models for analyzing the mechanism(s) of neonatal immune tolerance and the age‐dependence of human immunity. This disease has not only become representative of diseases caused by superantigens, but has also yielded a considerable amount of evidence about human immune reactions against superantigens. |
doi_str_mv | 10.1111/1348-0421.12094 |
format | Article |
fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492618416</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492618416</sourcerecordid><originalsourceid>FETCH-LOGICAL-c5324-c93a012466b8ba1dcf15adbdc712139a5d17c22d414653e5d7d1a1324e115b23</originalsourceid><addsrcrecordid>eNqNkb1uFDEUhUcIRJZATYcs0dBM4uuf-SkhghCUkEhEikRjeey7GwePZ7BnYPdleFa8bLIFDbixZH3n8706RfES6BHkcwxcNCUVDI6A0VY8Khb7l8fFgvJGlrKi9KB4ltIdpaxmjXhaHDBBORetXBS_Ln9g1N6T0ZlpjkiGJdGBYI9x5cKKBByCnrQnLizRTG6YE7EuoU6Yn-xs0JJuQzRJ85hFYXIrDM4QXA_TsHaB9NoFvyFjHPZwj9OtM857F8qIyaUp58iXSY-3Gz-YwZj8ic7DzOl58WSpfcIX9_dhcf3h_fXJx_L88vTs5O15aSRnojQt1xSYqKqu6TRYswSpbWdNDQx4q6WF2jBmBYhKcpS2tqAhJxFAdowfFm922jzm9xnTpHqXDHqv8_5zUiBaVkEjoPoPVLYgJedb6-u_0LthjiHvsaVE00ArZKaOd5SJQ0oRl2qMrtdxo4CqbclqW6naVqr-lJwTr-69c9ej3fMPrWZA7oCfzuPmXz51cXbxIC53uVwJrvc5Hb-pqua1VDefT9WnKynY1buv6ob_Bq7pwrY</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1454881945</pqid></control><display><type>article</type><title>Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus</title><source>MEDLINE</source><source>Wiley Online Library Free Content</source><source>Access via Wiley Online Library</source><source>Open Access Titles of Japan</source><source>Alma/SFX Local Collection</source><creator>Takahashi, Naoto ; Imanishi, Ken'ichi ; Uchiyama, Takehiko</creator><creatorcontrib>Takahashi, Naoto ; Imanishi, Ken'ichi ; Uchiyama, Takehiko</creatorcontrib><description>ABSTRACT
Since 1992, many neonates in neonatal intensive care units in Japan have been developing fever and systemic exanthema. Immunological analyses of neonates with these symptoms has revealed that the bacterial superantigen, toxic shock syndrome toxin‐1 (TSST‐1) is the cause. The name neonatal TSS‐like exanthematous disease (NTED) has been applied to this condition. The most striking clinical finding has been that none of the term neonates have developed shock or died of NTED. The timing of NTED epidemics has coincided with the spread of emerging TSST‐1‐producing methicillin‐resistant Staphylococcus aureus clones in Japan. The low frequency of pregnant women with positive anti‐TSST‐1 antibody titers could be one reason for the spread of NTED in Japan. Neonates have immune tolerance against TSST‐1 and may actively suppress the immune response to NTED with interleukin‐10. According to the T cell responses in infants or young children with diseases induced by TSST‐1, the pathophysiology of TSST‐1‐related diseases may be age‐dependent. The precise mechanism of anergy and deletion of specific T cells stimulated with TSST‐1 should be investigated in neonates infected with NTED. Both NTED and TSS might provide good models for analyzing the mechanism(s) of neonatal immune tolerance and the age‐dependence of human immunity. This disease has not only become representative of diseases caused by superantigens, but has also yielded a considerable amount of evidence about human immune reactions against superantigens.</description><identifier>ISSN: 0385-5600</identifier><identifier>EISSN: 1348-0421</identifier><identifier>DOI: 10.1111/1348-0421.12094</identifier><identifier>PMID: 24033495</identifier><language>eng</language><publisher>Australia: Blackwell Publishing Ltd</publisher><subject>Bacterial Toxins - genetics ; Bacterial Toxins - immunology ; clinical immunology ; Communicable Diseases, Emerging - immunology ; Communicable Diseases, Emerging - microbiology ; Enterotoxins - genetics ; Enterotoxins - immunology ; Female ; Humans ; Immunology ; Infant, Newborn ; Infant, Newborn, Diseases - immunology ; Infant, Newborn, Diseases - microbiology ; infection immunity ; Japan ; Male ; Medical research ; Methicillin-Resistant Staphylococcus aureus - genetics ; Methicillin-Resistant Staphylococcus aureus - immunology ; Methicillin-Resistant Staphylococcus aureus - physiology ; pathogenesis ; Pregnancy ; Staphylococcus aureus ; Staphylococcus infections ; Superantigens - genetics ; Superantigens - immunology ; toxin</subject><ispartof>Microbiology and immunology, 2013-11, Vol.57 (11), p.737-745</ispartof><rights>2013 The Societies and Wiley Publishing Asia Pty Ltd</rights><rights>2013 The Societies and Wiley Publishing Asia Pty Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5324-c93a012466b8ba1dcf15adbdc712139a5d17c22d414653e5d7d1a1324e115b23</citedby><cites>FETCH-LOGICAL-c5324-c93a012466b8ba1dcf15adbdc712139a5d17c22d414653e5d7d1a1324e115b23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1348-0421.12094$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1348-0421.12094$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,1433,27924,27925,45574,45575,46409,46833</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24033495$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takahashi, Naoto</creatorcontrib><creatorcontrib>Imanishi, Ken'ichi</creatorcontrib><creatorcontrib>Uchiyama, Takehiko</creatorcontrib><title>Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus</title><title>Microbiology and immunology</title><addtitle>Microbiol Immunol</addtitle><description>ABSTRACT
Since 1992, many neonates in neonatal intensive care units in Japan have been developing fever and systemic exanthema. Immunological analyses of neonates with these symptoms has revealed that the bacterial superantigen, toxic shock syndrome toxin‐1 (TSST‐1) is the cause. The name neonatal TSS‐like exanthematous disease (NTED) has been applied to this condition. The most striking clinical finding has been that none of the term neonates have developed shock or died of NTED. The timing of NTED epidemics has coincided with the spread of emerging TSST‐1‐producing methicillin‐resistant Staphylococcus aureus clones in Japan. The low frequency of pregnant women with positive anti‐TSST‐1 antibody titers could be one reason for the spread of NTED in Japan. Neonates have immune tolerance against TSST‐1 and may actively suppress the immune response to NTED with interleukin‐10. According to the T cell responses in infants or young children with diseases induced by TSST‐1, the pathophysiology of TSST‐1‐related diseases may be age‐dependent. The precise mechanism of anergy and deletion of specific T cells stimulated with TSST‐1 should be investigated in neonates infected with NTED. Both NTED and TSS might provide good models for analyzing the mechanism(s) of neonatal immune tolerance and the age‐dependence of human immunity. This disease has not only become representative of diseases caused by superantigens, but has also yielded a considerable amount of evidence about human immune reactions against superantigens.</description><subject>Bacterial Toxins - genetics</subject><subject>Bacterial Toxins - immunology</subject><subject>clinical immunology</subject><subject>Communicable Diseases, Emerging - immunology</subject><subject>Communicable Diseases, Emerging - microbiology</subject><subject>Enterotoxins - genetics</subject><subject>Enterotoxins - immunology</subject><subject>Female</subject><subject>Humans</subject><subject>Immunology</subject><subject>Infant, Newborn</subject><subject>Infant, Newborn, Diseases - immunology</subject><subject>Infant, Newborn, Diseases - microbiology</subject><subject>infection immunity</subject><subject>Japan</subject><subject>Male</subject><subject>Medical research</subject><subject>Methicillin-Resistant Staphylococcus aureus - genetics</subject><subject>Methicillin-Resistant Staphylococcus aureus - immunology</subject><subject>Methicillin-Resistant Staphylococcus aureus - physiology</subject><subject>pathogenesis</subject><subject>Pregnancy</subject><subject>Staphylococcus aureus</subject><subject>Staphylococcus infections</subject><subject>Superantigens - genetics</subject><subject>Superantigens - immunology</subject><subject>toxin</subject><issn>0385-5600</issn><issn>1348-0421</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkb1uFDEUhUcIRJZATYcs0dBM4uuf-SkhghCUkEhEikRjeey7GwePZ7BnYPdleFa8bLIFDbixZH3n8706RfES6BHkcwxcNCUVDI6A0VY8Khb7l8fFgvJGlrKi9KB4ltIdpaxmjXhaHDBBORetXBS_Ln9g1N6T0ZlpjkiGJdGBYI9x5cKKBByCnrQnLizRTG6YE7EuoU6Yn-xs0JJuQzRJ85hFYXIrDM4QXA_TsHaB9NoFvyFjHPZwj9OtM857F8qIyaUp58iXSY-3Gz-YwZj8ic7DzOl58WSpfcIX9_dhcf3h_fXJx_L88vTs5O15aSRnojQt1xSYqKqu6TRYswSpbWdNDQx4q6WF2jBmBYhKcpS2tqAhJxFAdowfFm922jzm9xnTpHqXDHqv8_5zUiBaVkEjoPoPVLYgJedb6-u_0LthjiHvsaVE00ArZKaOd5SJQ0oRl2qMrtdxo4CqbclqW6naVqr-lJwTr-69c9ej3fMPrWZA7oCfzuPmXz51cXbxIC53uVwJrvc5Hb-pqua1VDefT9WnKynY1buv6ob_Bq7pwrY</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Takahashi, Naoto</creator><creator>Imanishi, Ken'ichi</creator><creator>Uchiyama, Takehiko</creator><general>Blackwell Publishing Ltd</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>7X8</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>201311</creationdate><title>Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus</title><author>Takahashi, Naoto ; Imanishi, Ken'ichi ; Uchiyama, Takehiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5324-c93a012466b8ba1dcf15adbdc712139a5d17c22d414653e5d7d1a1324e115b23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Bacterial Toxins - genetics</topic><topic>Bacterial Toxins - immunology</topic><topic>clinical immunology</topic><topic>Communicable Diseases, Emerging - immunology</topic><topic>Communicable Diseases, Emerging - microbiology</topic><topic>Enterotoxins - genetics</topic><topic>Enterotoxins - immunology</topic><topic>Female</topic><topic>Humans</topic><topic>Immunology</topic><topic>Infant, Newborn</topic><topic>Infant, Newborn, Diseases - immunology</topic><topic>Infant, Newborn, Diseases - microbiology</topic><topic>infection immunity</topic><topic>Japan</topic><topic>Male</topic><topic>Medical research</topic><topic>Methicillin-Resistant Staphylococcus aureus - genetics</topic><topic>Methicillin-Resistant Staphylococcus aureus - immunology</topic><topic>Methicillin-Resistant Staphylococcus aureus - physiology</topic><topic>pathogenesis</topic><topic>Pregnancy</topic><topic>Staphylococcus aureus</topic><topic>Staphylococcus infections</topic><topic>Superantigens - genetics</topic><topic>Superantigens - immunology</topic><topic>toxin</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takahashi, Naoto</creatorcontrib><creatorcontrib>Imanishi, Ken'ichi</creatorcontrib><creatorcontrib>Uchiyama, Takehiko</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>MEDLINE - Academic</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Microbiology and immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takahashi, Naoto</au><au>Imanishi, Ken'ichi</au><au>Uchiyama, Takehiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus</atitle><jtitle>Microbiology and immunology</jtitle><addtitle>Microbiol Immunol</addtitle><date>2013-11</date><risdate>2013</risdate><volume>57</volume><issue>11</issue><spage>737</spage><epage>745</epage><pages>737-745</pages><issn>0385-5600</issn><eissn>1348-0421</eissn><abstract>ABSTRACT
Since 1992, many neonates in neonatal intensive care units in Japan have been developing fever and systemic exanthema. Immunological analyses of neonates with these symptoms has revealed that the bacterial superantigen, toxic shock syndrome toxin‐1 (TSST‐1) is the cause. The name neonatal TSS‐like exanthematous disease (NTED) has been applied to this condition. The most striking clinical finding has been that none of the term neonates have developed shock or died of NTED. The timing of NTED epidemics has coincided with the spread of emerging TSST‐1‐producing methicillin‐resistant Staphylococcus aureus clones in Japan. The low frequency of pregnant women with positive anti‐TSST‐1 antibody titers could be one reason for the spread of NTED in Japan. Neonates have immune tolerance against TSST‐1 and may actively suppress the immune response to NTED with interleukin‐10. According to the T cell responses in infants or young children with diseases induced by TSST‐1, the pathophysiology of TSST‐1‐related diseases may be age‐dependent. The precise mechanism of anergy and deletion of specific T cells stimulated with TSST‐1 should be investigated in neonates infected with NTED. Both NTED and TSS might provide good models for analyzing the mechanism(s) of neonatal immune tolerance and the age‐dependence of human immunity. This disease has not only become representative of diseases caused by superantigens, but has also yielded a considerable amount of evidence about human immune reactions against superantigens.</abstract><cop>Australia</cop><pub>Blackwell Publishing Ltd</pub><pmid>24033495</pmid><doi>10.1111/1348-0421.12094</doi><tpages>9</tpages></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0385-5600 |
ispartof | Microbiology and immunology, 2013-11, Vol.57 (11), p.737-745 |
issn | 0385-5600 1348-0421 |
language | eng |
recordid | cdi_proquest_miscellaneous_1492618416 |
source | MEDLINE; Wiley Online Library Free Content; Access via Wiley Online Library; Open Access Titles of Japan; Alma/SFX Local Collection |
subjects | Bacterial Toxins - genetics Bacterial Toxins - immunology clinical immunology Communicable Diseases, Emerging - immunology Communicable Diseases, Emerging - microbiology Enterotoxins - genetics Enterotoxins - immunology Female Humans Immunology Infant, Newborn Infant, Newborn, Diseases - immunology Infant, Newborn, Diseases - microbiology infection immunity Japan Male Medical research Methicillin-Resistant Staphylococcus aureus - genetics Methicillin-Resistant Staphylococcus aureus - immunology Methicillin-Resistant Staphylococcus aureus - physiology pathogenesis Pregnancy Staphylococcus aureus Staphylococcus infections Superantigens - genetics Superantigens - immunology toxin |
title | Overall picture of an emerging neonatal infectious disease induced by a superantigenic exotoxin mainly produced by methicillin-resistant Staphylococcus aureus |
url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-23T08%3A47%3A51IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Overall%20picture%20of%20an%20emerging%20neonatal%20infectious%20disease%20induced%20by%20a%20superantigenic%20exotoxin%20mainly%20produced%20by%20methicillin-resistant%20Staphylococcus%20aureus&rft.jtitle=Microbiology%20and%20immunology&rft.au=Takahashi,%20Naoto&rft.date=2013-11&rft.volume=57&rft.issue=11&rft.spage=737&rft.epage=745&rft.pages=737-745&rft.issn=0385-5600&rft.eissn=1348-0421&rft_id=info:doi/10.1111/1348-0421.12094&rft_dat=%3Cproquest_cross%3E1492618416%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1454881945&rft_id=info:pmid/24033495&rfr_iscdi=true |