Contribution of 24 obesity-associated genetic variants to insulin resistance, pancreatic beta-cell function and type 2 diabetes risk in the French population

Context: Obesity is the major determinant of type 2 diabetes (T2D), presumably through its effect on insulin resistance. Genome-wide association studies reported many single-nucleotide polymorphisms (SNPs) that increase obesity risk and body mass index (BMI), but their impact on T2D-related traits a...

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Veröffentlicht in:	International Journal of Obesity 2013-07, Vol.37 (7), p.980-985
Hauptverfasser:	Robiou-du-Pont, S, Bonnefond, A, Yengo, L, Vaillant, E, Lobbens, S, Durand, E, Weill, J, Lantieri, O, Balkau, B, Charpentier, G, Marre, M, Froguel, P, Meyre, D
Format:	Artikel
Sprache:	eng
Schlagworte:	631/208/727/2000 692/699/2743/137/773 692/699/2743/393 692/700/478/174 Adult Aged Alpha-Ketoglutarate-Dependent Dioxygenase FTO Analysis Biological and medical sciences Body Mass Index Case studies Compensation Complications and side effects Cyclin-Dependent Kinase 5 - genetics Demographic aspects Diabetes Diabetes Mellitus, Type 2 - epidemiology Diabetes Mellitus, Type 2 - genetics Diabetes. Impaired glucose tolerance Endocrine pancreas. Apud cells (diseases) Endocrinology Endocrinopathies Epidemiology Etiopathogenesis. Screening. Investigations. Target tissue resistance European Continental Ancestry Group - genetics Female France - epidemiology Genetic aspects Genetic Predisposition to Disease Genetic variance Genetic Variation Genome-Wide Association Study Genomes Genotype Genotype & phenotype Health Promotion and Disease Prevention Health risks Homeostasis Humans Insulin Receptor Substrate Proteins - genetics Insulin resistance Insulin Resistance - genetics Insulin-Secreting Cells Internal Medicine Longitudinal Studies Male Medical sciences Medicine Medicine & Public Health Metabolic Diseases Metabolism Middle Aged Obesity Obesity - epidemiology Obesity - genetics original-article Phenotype Phosphoric Diester Hydrolases - genetics Polymorphism, Single Nucleotide Proteins - genetics Public Health Pyrophosphatases - genetics Risk Factors tRNA Methyltransferases Type 2 diabetes
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