A novel classification of colorectal tumors based on microsatellite instability, the CpG island methylator phenotype and chromosomal instability: implications for prognosis

We studied the overlap between the major (epi)genomic events microsatellite instability (MSI), the CpG island methylator phenotype (CIMP) and chromosomal instability (CIN) in colorectal cancer (CRC), and whether specific (epi)genotypes were associated with CRC-related deaths. Molecular analyses usin...

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Veröffentlicht in:	Annals of oncology 2013-08, Vol.24 (8), p.2048-2056
Hauptverfasser:	Simons, C.C.J.M., Hughes, L.A.E., Smits, K.M., Khalid-de Bakker, C.A., de Bruïne, A.P., Carvalho, B., Meijer, G.A., Schouten, L.J., van den Brandt, P.A., Weijenberg, M.P., van Engeland, M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants Aged Antineoplastic agents Biological and medical sciences chromosomal instability Chromosomal Instability - genetics colorectal neoplasms Colorectal Neoplasms - diagnosis Colorectal Neoplasms - genetics CpG Islands - genetics DNA Methylation - genetics Female Gastroenterology. Liver. Pancreas. Abdomen Genotype Humans Male Medical sciences methylation Microsatellite Instability Middle Aged Multiple tumors. Solid tumors. Tumors in childhood (general aspects) Pharmacology. Drug treatments Prognosis Stomach. Duodenum. Small intestine. Colon. Rectum. Anus Surveys and Questionnaires Tumors
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