miRNA expression is modulated over time after focal ischaemia: up‐regulation of miR–347 promotes neuronal apoptosis

Despite the large number of molecules reported as being over‐expressed after ischaemia, little is known regarding their regulation. miRNAs are potent post‐transcriptional regulators of gene expression, and reports have shown differentially miRNA expression in response to focal cerebral ischaemia. Th...

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Veröffentlicht in:	The FEBS journal 2013-12, Vol.280 (23), p.6233-6246
Hauptverfasser:	Gubern, Carme, Camós, Susanna, Ballesteros, Iván, Rodríguez, Rocío, Romera, Víctor G., Cañadas, Roberto, Lizasoain, Ignacio, Moro, María A., Serena, Joaquín, Mallolas, Judith, Castellanos, Mar
Format:	Artikel
Sprache:	eng
Schlagworte:	Acsl4 ADP-Ribosylation Factors - genetics ADP-Ribosylation Factors - metabolism Animals Apoptosis Arf3 Biomarkers - metabolism Blotting, Western Cells, Cultured cerebral cortex Coenzyme A Ligases - genetics Coenzyme A Ligases - metabolism Gene expression Gene Expression Profiling Immediate-Early Proteins - genetics Immediate-Early Proteins - metabolism Ischemia Ischemia - genetics Ischemia - metabolism Ischemia - pathology Male MCAO Medical research MicroRNAs - genetics miR‐347 Neurology Neurons - metabolism Neurons - pathology Oligonucleotide Array Sequence Analysis Rats Rats, Wistar Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction Ribonucleic acid RNA RNA, Messenger - genetics Tumor Suppressor Proteins - genetics Tumor Suppressor Proteins - metabolism
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