Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003
BACKGROUND Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system–related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and ner...
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| Veröffentlicht in: | Birth defects research. A Clinical and molecular teratology 2013-10, Vol.97 (10), p.641-648 |
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| container_title | Birth defects research. A Clinical and molecular teratology |
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| creator | Sauber-Schatz, Erin K. Bodnar, Lisa M. Weiss, Harold B. Wilson, John W. Pearlman, Mark D. Markovic, Nina |
| description | BACKGROUND
Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system–related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.
METHODS
Through a case–control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999–2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.
RESULTS
Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63–1.56 and 2.44; 95% confidence interval, 1.08–5.53 among breech presentation infants. Probabilistic bias analysis supported these findings.
CONCLUSION
No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A) 97:641–648, 2013. © 2013 Wiley Periodicals, Inc. |
| doi_str_mv | 10.1002/bdra.23143 |
| format | Article |
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Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system–related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.
METHODS
Through a case–control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999–2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.
RESULTS
Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63–1.56 and 2.44; 95% confidence interval, 1.08–5.53 among breech presentation infants. Probabilistic bias analysis supported these findings.
CONCLUSION
No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A) 97:641–648, 2013. © 2013 Wiley Periodicals, Inc.</description><identifier>ISSN: 1542-0752</identifier><identifier>EISSN: 1542-0760</identifier><identifier>DOI: 10.1002/bdra.23143</identifier><identifier>PMID: 23893941</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Accidents, Occupational ; Accidents, Traffic ; Adult ; African Americans ; birth defects ; Breech Presentation - epidemiology ; Breech Presentation - ethnology ; Case reports ; central nervous system ; European Continental Ancestry Group ; Female ; Hispanic Americans ; Humans ; injury ; Male ; Middle Aged ; Nervous System Malformations - epidemiology ; Nervous System Malformations - ethnology ; Odds Ratio ; Pregnancy ; Pregnancy Complications ; Prevalence ; Public Health Surveillance ; Registries ; Retrospective Studies ; Texas ; Texas - epidemiology</subject><ispartof>Birth defects research. A Clinical and molecular teratology, 2013-10, Vol.97 (10), p.641-648</ispartof><rights>Copyright © 2013 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4363-54e9f34fdba3615411645ad1b53e05d9267ac82619791d1fac7c266d356da19f3</citedby><cites>FETCH-LOGICAL-c4363-54e9f34fdba3615411645ad1b53e05d9267ac82619791d1fac7c266d356da19f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fbdra.23143$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fbdra.23143$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23893941$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sauber-Schatz, Erin K.</creatorcontrib><creatorcontrib>Bodnar, Lisa M.</creatorcontrib><creatorcontrib>Weiss, Harold B.</creatorcontrib><creatorcontrib>Wilson, John W.</creatorcontrib><creatorcontrib>Pearlman, Mark D.</creatorcontrib><creatorcontrib>Markovic, Nina</creatorcontrib><title>Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003</title><title>Birth defects research. A Clinical and molecular teratology</title><addtitle>Birth Defects Research Part A: Clinical and Molecular Teratology</addtitle><description>BACKGROUND
Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system–related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.
METHODS
Through a case–control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999–2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.
RESULTS
Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63–1.56 and 2.44; 95% confidence interval, 1.08–5.53 among breech presentation infants. Probabilistic bias analysis supported these findings.
CONCLUSION
No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A) 97:641–648, 2013. © 2013 Wiley Periodicals, Inc.</description><subject>Accidents, Occupational</subject><subject>Accidents, Traffic</subject><subject>Adult</subject><subject>African Americans</subject><subject>birth defects</subject><subject>Breech Presentation - epidemiology</subject><subject>Breech Presentation - ethnology</subject><subject>Case reports</subject><subject>central nervous system</subject><subject>European Continental Ancestry Group</subject><subject>Female</subject><subject>Hispanic Americans</subject><subject>Humans</subject><subject>injury</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Nervous System Malformations - epidemiology</subject><subject>Nervous System Malformations - ethnology</subject><subject>Odds Ratio</subject><subject>Pregnancy</subject><subject>Pregnancy Complications</subject><subject>Prevalence</subject><subject>Public Health Surveillance</subject><subject>Registries</subject><subject>Retrospective Studies</subject><subject>Texas</subject><subject>Texas - epidemiology</subject><issn>1542-0752</issn><issn>1542-0760</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkMlOwzAURS0EYt7wAchLhAj4eazZlTJKDBKDYGc5sQOBNi12AuTvMRS6RKzsxblHTwehDSC7QAjdy12wu5QBZ3NoGQSnGVGSzM_-gi6hlRifE8uUUotoibKeZprDMro4q5_b0GHXhqp-xJPgH2tbFx22tcO1D2_jNuLYxcaPcF6F5gk7X_qiifv41n_YuINBa42bMaaEsDW0UNph9Os_7yq6Oz66HZxm51cnZ4P-eVZwJlkmuNcl46XLLZPpSADJhXWQC-aJcJpKZYselaCVBgelLVRBpXRMSGchTVfR1tQ7CePX1sfGjKpY-OHQ1j4dbIAnB1AN9B8oZ1oLJnoJ3Z6iRRjHGHxpJqEa2dAZIOartPkqbb5LJ3jzx9vmI-9m6G_aBMAUeK-GvvtDZQ4Or_u_0my6qVLwj9nGhhcjFVPC3F-emJve4OEaBtRcsE-N6ZSJ</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Sauber-Schatz, Erin K.</creator><creator>Bodnar, Lisa M.</creator><creator>Weiss, Harold B.</creator><creator>Wilson, John W.</creator><creator>Pearlman, Mark D.</creator><creator>Markovic, Nina</creator><general>Blackwell Publishing Ltd</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7TK</scope></search><sort><creationdate>201310</creationdate><title>Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003</title><author>Sauber-Schatz, Erin K. ; Bodnar, Lisa M. ; Weiss, Harold B. ; Wilson, John W. ; Pearlman, Mark D. ; Markovic, Nina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4363-54e9f34fdba3615411645ad1b53e05d9267ac82619791d1fac7c266d356da19f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Accidents, Occupational</topic><topic>Accidents, Traffic</topic><topic>Adult</topic><topic>African Americans</topic><topic>birth defects</topic><topic>Breech Presentation - epidemiology</topic><topic>Breech Presentation - ethnology</topic><topic>Case reports</topic><topic>central nervous system</topic><topic>European Continental Ancestry Group</topic><topic>Female</topic><topic>Hispanic Americans</topic><topic>Humans</topic><topic>injury</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Nervous System Malformations - epidemiology</topic><topic>Nervous System Malformations - ethnology</topic><topic>Odds Ratio</topic><topic>Pregnancy</topic><topic>Pregnancy Complications</topic><topic>Prevalence</topic><topic>Public Health Surveillance</topic><topic>Registries</topic><topic>Retrospective Studies</topic><topic>Texas</topic><topic>Texas - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sauber-Schatz, Erin K.</creatorcontrib><creatorcontrib>Bodnar, Lisa M.</creatorcontrib><creatorcontrib>Weiss, Harold B.</creatorcontrib><creatorcontrib>Wilson, John W.</creatorcontrib><creatorcontrib>Pearlman, Mark D.</creatorcontrib><creatorcontrib>Markovic, Nina</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Neurosciences Abstracts</collection><jtitle>Birth defects research. A Clinical and molecular teratology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sauber-Schatz, Erin K.</au><au>Bodnar, Lisa M.</au><au>Weiss, Harold B.</au><au>Wilson, John W.</au><au>Pearlman, Mark D.</au><au>Markovic, Nina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003</atitle><jtitle>Birth defects research. A Clinical and molecular teratology</jtitle><addtitle>Birth Defects Research Part A: Clinical and Molecular Teratology</addtitle><date>2013-10</date><risdate>2013</risdate><volume>97</volume><issue>10</issue><spage>641</spage><epage>648</epage><pages>641-648</pages><issn>1542-0752</issn><eissn>1542-0760</eissn><abstract>BACKGROUND
Case reports and series have suggested an association between injury during pregnancy and several nervous system and nervous system–related adverse fetal/neonatal outcomes. This study's purpose is to further determine if there is an association between injury during pregnancy and nervous system birth defects in infancy.
METHODS
Through a case–control study, the association between injury during pregnancy and nervous system birth defects was tested using the Texas Birth Defects Registry (1999–2003). Semiautomated probabilistic bias analysis was used to correct for systematic error from misclassification of injury during pregnancy.
RESULTS
Of the 59,750 infants eligible for this study, 4144 (6.94%) were diagnosed with a nervous system birth defect and 315 (0.53%) of the infants' mothers were injured during pregnancy. Among these 315 women, 25 (7.94%) delivered an infant with a subsequent nervous system birth defect. The adjusted odds ratio for the association between injury during pregnancy and nervous system birth defects among all study infants was 1.00; 95% confidence interval, 0.63–1.56 and 2.44; 95% confidence interval, 1.08–5.53 among breech presentation infants. Probabilistic bias analysis supported these findings.
CONCLUSION
No association between injury during pregnancy and nervous system birth defects was identified. Further exploration into the association among breech presentation infants is warranted. Birth Defects Research (Part A) 97:641–648, 2013. © 2013 Wiley Periodicals, Inc.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>23893941</pmid><doi>10.1002/bdra.23143</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Birth defects research. A Clinical and molecular teratology, 2013-10, Vol.97 (10), p.641-648 |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Accidents, Occupational Accidents, Traffic Adult African Americans birth defects Breech Presentation - epidemiology Breech Presentation - ethnology Case reports central nervous system European Continental Ancestry Group Female Hispanic Americans Humans injury Male Middle Aged Nervous System Malformations - epidemiology Nervous System Malformations - ethnology Odds Ratio Pregnancy Pregnancy Complications Prevalence Public Health Surveillance Registries Retrospective Studies Texas Texas - epidemiology |
| title | Injury during pregnancy and nervous system birth defects: Texas, 1999 to 2003 |
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