Impact of Hey2 and COUP-TFII on genes involved in arteriovenous differentiation in primary human arterial and venous endothelial cells

Arteries and veins show marked differences in their anatomy, physiology and genetic expression pattern. In this study, we analyzed impact of overexpression or downregulation of arterial marker gene Hey2 and venous marker gene COUP-TFII in human venous and arterial endothelial cells on genes involved...

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Veröffentlicht in:	Basic research in cardiology 2013-07, Vol.108 (4), p.362-362, Article 362
Hauptverfasser:	Korten, Slobodanka, Brunssen, Coy, Poitz, David M., Großklaus, Sylvia, Brux, Melanie, Schnittler, Hans-Joachim, Strasser, Ruth H., Bornstein, Stefan R., Morawietz, Henning, Goettsch, Winfried
Format:	Artikel
Sprache:	eng
Schlagworte:	Arteries Basic Helix-Loop-Helix Transcription Factors - metabolism Biomarkers - metabolism Cardiology Cell Differentiation - physiology Cells, Cultured COUP Transcription Factor II - metabolism Down-Regulation - physiology Endothelium, Vascular - cytology Endothelium, Vascular - metabolism Ephrin-B2 - metabolism Humans Medicine Medicine & Public Health Original Contribution Receptors, Notch - metabolism Repressor Proteins - metabolism Signal Transduction - physiology Umbilical Arteries - cytology Umbilical Arteries - metabolism Umbilical Veins - cytology Umbilical Veins - metabolism Up-Regulation - physiology Vascular Endothelial Growth Factor A - metabolism
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