Dimethyl sulfoxide (DMSO) as a potential contrast agent for brain tumors

Dimethyl sulfoxide (DMSO) as a potential contrast agent for brain tumors

Dimethyl sulfoxide (DMSO) is commonly used in preclinical studies of animal models of high‐grade glioma as a solvent for chemotherapeutic agents. A strong DMSO signal was detected by single‐voxel MRS in the brain of three C57BL/6 control mice during a pilot study of DMSO tolerance after intragastric...

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Veröffentlicht in:NMR in biomedicine 2013-02, Vol.26 (2), p.173-184
Hauptverfasser: Delgado-Goñi, T., Martín-Sitjar, J., Simões, R. V., Acosta, M., Lope-Piedrafita, S., Arús, C.
Format: Artikel
Sprache:eng
Schlagworte:
Animal models
Animals
Brain Neoplasms - metabolism
Brain Neoplasms - pathology
contrast enhancement
Contrast Media - chemistry
Contrast Media - pharmacokinetics
Dimethyl Sulfoxide - chemistry
Dimethyl Sulfoxide - pharmacokinetics
Feasibility Studies
Female
GL261 cells
Glioblastoma - metabolism
Glioblastoma - pathology
Magnetic Resonance Imaging - methods
Magnetic Resonance Spectroscopy - methods
Metabolic Clearance Rate
Mice
Mice, Inbred C57BL
perturbation-enhanced MRSI
Reproducibility of Results
Sensitivity and Specificity
Tissue Distribution
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Zusammenfassung:Dimethyl sulfoxide (DMSO) is commonly used in preclinical studies of animal models of high‐grade glioma as a solvent for chemotherapeutic agents. A strong DMSO signal was detected by single‐voxel MRS in the brain of three C57BL/6 control mice during a pilot study of DMSO tolerance after intragastric administration. This led us to investigate the accumulation and wash‐out kinetics of DMSO in both normal brain parenchyma (n = 3 control mice) by single‐voxel MRS, and in 12 GL261 glioblastomas (GBMs) by single‐voxel MRS (n = 3) and MRSI (n = 9). DMSO accumulated differently in each tissue type, reaching its highest concentration in tumors: 6.18 ± 0.85 µmol/g water, 1.5‐fold higher than in control mouse brain (p 
ISSN:0952-3480
1099-1492
DOI:10.1002/nbm.2832