Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats

Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats

The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 m...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Journal of medical sciences (Faisalābād, Pakistan) Pakistan), 2013, Vol.13 (4), p.253-260
Hauptverfasser: Akanji, M.A., Yakubu, M.T., Kazeem, M.I.
Format: Artikel
Sprache:eng
Schlagworte:
Acid phosphatase
Rauvolfia
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 260
container_issue 4
container_start_page 253
container_title Journal of medical sciences (Faisalābād, Pakistan)
container_volume 13
creator Akanji, M.A.
Yakubu, M.T.
Kazeem, M.I.
description The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg super( -1) b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p
doi_str_mv 10.3923/jms.2013.253.260
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492609822</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1492609822</sourcerecordid><originalsourceid>FETCH-LOGICAL-c2330-631a82d745f178025fc10093e700db25d4658f9c2286a2eba6d2a87def51b80e3</originalsourceid><addsrcrecordid>eNotkM1LAzEQxYMoWKt3jzl62ZrP3eyxlGqFglIqHkOaTSQlu1k3aWn9681SD8M8Hm-Gxw-AR4xmtCb0ed_GGUGYzgjPU6IrMMECk4JXpLrOuhSkYKxit-Auxj1CTHDMJqBdnfvgXe8a0zoNVdfAbTg5HXz4dlp5-BGS6ZLLKlg4_zmYcIhweUqD0mm0NupwDN46BY-hdSkMWc3tr_FwE0KCroNfLiY15GCK9-DGKh_Nw_-egs-X5XaxKtbvr2-L-brQhFJUlBQrQZqKcYsrgQi3GiNUU1Mh1OwIb1jJha01IaJUxOxU2RAlqsZYjncCGToFT5e__RBy5Zhk66I23qtu7C8xqzOiWhCSo-gS1UOIcTBW9oNr1XCWGMmRrMxk5UhWZrIyn9E_qjBtVQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1492609822</pqid></control><display><type>article</type><title>Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats</title><source>EZB-FREE-00999 freely available EZB journals</source><source>Science Alert</source><creator>Akanji, M.A. ; Yakubu, M.T. ; Kazeem, M.I.</creator><creatorcontrib>Akanji, M.A. ; Yakubu, M.T. ; Kazeem, M.I.</creatorcontrib><description>The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg super( -1) b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p&lt;0.05) in the concentration of the Low-density Lipoprotein Cholesterol (LDL-C), triglyceride and atherogenic indices while a dose-dependent significant increase (p&lt;0.05) occurred in the High-density Lipoprotein Cholesterol (HDL-C) concentration. Significant changes were also observed (p&lt;0.05) in the activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) in all the tissues studied except small intestine. There were significant fluctuations (p&lt;0.05) in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the tissues except in the kidney. The results suggest that aqueous extract of Rauvolfia vomitoria root possesses hypolipidemic potential but caused alterations in the concentration of the enzymes studied and so may not be completely safe at the dose used in this study.</description><identifier>ISSN: 1682-4474</identifier><identifier>EISSN: 1812-5727</identifier><identifier>DOI: 10.3923/jms.2013.253.260</identifier><language>eng</language><subject>Acid phosphatase ; Rauvolfia</subject><ispartof>Journal of medical sciences (Faisalābād, Pakistan), 2013, Vol.13 (4), p.253-260</ispartof><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c2330-631a82d745f178025fc10093e700db25d4658f9c2286a2eba6d2a87def51b80e3</citedby><cites>FETCH-LOGICAL-c2330-631a82d745f178025fc10093e700db25d4658f9c2286a2eba6d2a87def51b80e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>315,781,785,4025,4125,27928,27929,27930</link.rule.ids></links><search><creatorcontrib>Akanji, M.A.</creatorcontrib><creatorcontrib>Yakubu, M.T.</creatorcontrib><creatorcontrib>Kazeem, M.I.</creatorcontrib><title>Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats</title><title>Journal of medical sciences (Faisalābād, Pakistan)</title><description>The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg super( -1) b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p&lt;0.05) in the concentration of the Low-density Lipoprotein Cholesterol (LDL-C), triglyceride and atherogenic indices while a dose-dependent significant increase (p&lt;0.05) occurred in the High-density Lipoprotein Cholesterol (HDL-C) concentration. Significant changes were also observed (p&lt;0.05) in the activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) in all the tissues studied except small intestine. There were significant fluctuations (p&lt;0.05) in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the tissues except in the kidney. The results suggest that aqueous extract of Rauvolfia vomitoria root possesses hypolipidemic potential but caused alterations in the concentration of the enzymes studied and so may not be completely safe at the dose used in this study.</description><subject>Acid phosphatase</subject><subject>Rauvolfia</subject><issn>1682-4474</issn><issn>1812-5727</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNotkM1LAzEQxYMoWKt3jzl62ZrP3eyxlGqFglIqHkOaTSQlu1k3aWn9681SD8M8Hm-Gxw-AR4xmtCb0ed_GGUGYzgjPU6IrMMECk4JXpLrOuhSkYKxit-Auxj1CTHDMJqBdnfvgXe8a0zoNVdfAbTg5HXz4dlp5-BGS6ZLLKlg4_zmYcIhweUqD0mm0NupwDN46BY-hdSkMWc3tr_FwE0KCroNfLiY15GCK9-DGKh_Nw_-egs-X5XaxKtbvr2-L-brQhFJUlBQrQZqKcYsrgQi3GiNUU1Mh1OwIb1jJha01IaJUxOxU2RAlqsZYjncCGToFT5e__RBy5Zhk66I23qtu7C8xqzOiWhCSo-gS1UOIcTBW9oNr1XCWGMmRrMxk5UhWZrIyn9E_qjBtVQ</recordid><startdate>2013</startdate><enddate>2013</enddate><creator>Akanji, M.A.</creator><creator>Yakubu, M.T.</creator><creator>Kazeem, M.I.</creator><scope>AAYXX</scope><scope>CITATION</scope><scope>7U7</scope><scope>C1K</scope></search><sort><creationdate>2013</creationdate><title>Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats</title><author>Akanji, M.A. ; Yakubu, M.T. ; Kazeem, M.I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2330-631a82d745f178025fc10093e700db25d4658f9c2286a2eba6d2a87def51b80e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Acid phosphatase</topic><topic>Rauvolfia</topic><toplevel>online_resources</toplevel><creatorcontrib>Akanji, M.A.</creatorcontrib><creatorcontrib>Yakubu, M.T.</creatorcontrib><creatorcontrib>Kazeem, M.I.</creatorcontrib><collection>CrossRef</collection><collection>Toxicology Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>Journal of medical sciences (Faisalābād, Pakistan)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Akanji, M.A.</au><au>Yakubu, M.T.</au><au>Kazeem, M.I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats</atitle><jtitle>Journal of medical sciences (Faisalābād, Pakistan)</jtitle><date>2013</date><risdate>2013</risdate><volume>13</volume><issue>4</issue><spage>253</spage><epage>260</epage><pages>253-260</pages><issn>1682-4474</issn><eissn>1812-5727</eissn><abstract>The aim of this study was to investigate the hypolipidemic potential of aqueous extract of Rauvolfia vomitoria root and assess its toxicological effect in selected tissues of rats. Aqueous extract of Rauvolfia vomitoria root was administered to wistar rats daily at 24 h interval at a dosage of 200 mg kg super( -1) b.wt. following which the rats were sacrificed after receiving 1, 3, 5, 10, 20 and 30 daily oral doses. Administration of the extract produced significant reduction (p&lt;0.05) in the concentration of the Low-density Lipoprotein Cholesterol (LDL-C), triglyceride and atherogenic indices while a dose-dependent significant increase (p&lt;0.05) occurred in the High-density Lipoprotein Cholesterol (HDL-C) concentration. Significant changes were also observed (p&lt;0.05) in the activities of alkaline phosphatase (ALP) and acid phosphatase (ACP) in all the tissues studied except small intestine. There were significant fluctuations (p&lt;0.05) in the activities of aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in the tissues except in the kidney. The results suggest that aqueous extract of Rauvolfia vomitoria root possesses hypolipidemic potential but caused alterations in the concentration of the enzymes studied and so may not be completely safe at the dose used in this study.</abstract><doi>10.3923/jms.2013.253.260</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1682-4474
ispartof Journal of medical sciences (Faisalābād, Pakistan), 2013, Vol.13 (4), p.253-260
issn 1682-4474
1812-5727
language eng
recordid cdi_proquest_miscellaneous_1492609822
source EZB-FREE-00999 freely available EZB journals; Science Alert
subjects Acid phosphatase
Rauvolfia
title Hypolipidemic and Toxicological Potential of Aqueous Extract of Rauvolfia vomitoria Afzel Root in Wistar Rats
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-11T23%3A31%3A22IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Hypolipidemic%20and%20Toxicological%20Potential%20of%20Aqueous%20Extract%20of%20Rauvolfia%20vomitoria%20Afzel%20Root%20in%20Wistar%20Rats&rft.jtitle=Journal%20of%20medical%20sciences%20(Faisala%CC%84ba%CC%84d,%20Pakistan)&rft.au=Akanji,%20M.A.&rft.date=2013&rft.volume=13&rft.issue=4&rft.spage=253&rft.epage=260&rft.pages=253-260&rft.issn=1682-4474&rft.eissn=1812-5727&rft_id=info:doi/10.3923/jms.2013.253.260&rft_dat=%3Cproquest_cross%3E1492609822%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1492609822&rft_id=info:pmid/&rfr_iscdi=true