Chemical-genetic identification of the biochemical targets of polyalkyl guanidinium biocides

Alkylated guanidinium compounds exhibit microbiocidal activity in marine environments, yet the mode of action of these compounds has not been defined. A comprehensive chemical-genetic approach in budding yeast was used to define the biological processes affected by these compounds. N-Butyl-N'-d...

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Veröffentlicht in:	Organic & biomolecular chemistry 2013-07, Vol.11 (26), p.4359-4366
Hauptverfasser:	Bowie, Drew, Parvizi, Paria, Duncan, Dustin, Nelson, Christopher J, Fyles, Thomas M
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkylation Amino acids Disinfectants - chemistry Disinfectants - metabolism Gene Expression Regulation, Fungal - drug effects Guanidine - chemistry Guanidine - metabolism Saccharomyces cerevisiae Saccharomycetales - drug effects Saccharomycetales - genetics Saccharomycetales - physiology Tryptophan - metabolism
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