The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma
Background Although psammoma bodies (PB) are found in up to 50 % of papillary thyroid carcinomas (PTC), their clinicopathological significance remains uncertain. The aim of the present study was to determine the clinicopathological significance of PB and the correlation between PB and ultrasonograph...
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| Veröffentlicht in: | World journal of surgery 2013-10, Vol.37 (10), p.2330-2335 |
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| creator | Pyo, Jung-Soo Kang, Guhyun Kim, Dong-Hoon Park, Chanheun Kim, Joo Heon Sohn, Jin Hee |
| description | Background
Although psammoma bodies (PB) are found in up to 50 % of papillary thyroid carcinomas (PTC), their clinicopathological significance remains uncertain. The aim of the present study was to determine the clinicopathological significance of PB and the correlation between PB and ultrasonographic intratumoral calcification in PTC.
Methods
The clinicopathological parameters, ultrasonographic calcifications, and the presence of PB were evaluated in 258 surgically resected conventional PTC.
Results
Psammoma bodies were found in 141 of 258 PTC (54.7 %). The presence of PB was significantly correlated with tumor multifocality, extrathyroidal extension, and lymph node metastasis (
P
= 0.009,
P
= 0.004, and
P
1 cm) than in papillary microcarcinomas (≤1 cm) (
P
|
| doi_str_mv | 10.1007/s00268-013-2107-5 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1492608479</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1428773884</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4552-be495368c5b68e55429590d8953c502d606e6365fe424a3a64e0a7ee6e6b88023</originalsourceid><addsrcrecordid>eNqNkU-LFDEQxRtR3HH1A3iRgBcvrZW_nT66g6srCw46i8eQSVfPZOlOxmRaGfzyZuhVRBA9JRS_93hVr6qeUnhJAZpXGYApXQPlNaPQ1PJetaCCs5pxxu9XC-BKlD_lZ9WjnG8BaKNAPazOGG-oAtYsqu_rHZJVitsQ88E78hEH_GqDQxJ7ssp2HONoyUXsPGZiQ0duhkOyOYa4TXa_K4qrUAaHaYzJDmRpB-d77-zBx5CJD2Rl934YbDqS9e6You8Kk5wPxfZx9aC3Q8Ynd-95dXP5Zr18V19_eHu1fH1dOyElqzcoWsmVdnKjNEopWCtb6HQZOgmsKyuh4kr2KJiw3CqBYBvEMt1oDYyfVy9m332KXybMBzP67LCkChinbKhomQItmvY_UKabhmstCvr8D_Q2TimURQrFBWUglCoUnSmXYs4Je7NPfiznMBTMqUQzl2hKieZUopFF8-zOedqM2P1S_GytAO0MfPMDHv_taD6__3RxCUqy0zHYrM1FFraYfov910Q_AEXSt2I</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1434120466</pqid></control><display><type>article</type><title>The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma</title><source>MEDLINE</source><source>Wiley Journals</source><source>SpringerLink Journals</source><creator>Pyo, Jung-Soo ; Kang, Guhyun ; Kim, Dong-Hoon ; Park, Chanheun ; Kim, Joo Heon ; Sohn, Jin Hee</creator><creatorcontrib>Pyo, Jung-Soo ; Kang, Guhyun ; Kim, Dong-Hoon ; Park, Chanheun ; Kim, Joo Heon ; Sohn, Jin Hee</creatorcontrib><description>Background
Although psammoma bodies (PB) are found in up to 50 % of papillary thyroid carcinomas (PTC), their clinicopathological significance remains uncertain. The aim of the present study was to determine the clinicopathological significance of PB and the correlation between PB and ultrasonographic intratumoral calcification in PTC.
Methods
The clinicopathological parameters, ultrasonographic calcifications, and the presence of PB were evaluated in 258 surgically resected conventional PTC.
Results
Psammoma bodies were found in 141 of 258 PTC (54.7 %). The presence of PB was significantly correlated with tumor multifocality, extrathyroidal extension, and lymph node metastasis (
P
= 0.009,
P
= 0.004, and
P
< 0.001, respectively), but not with the BRAF
V600E
mutation. Higher incidences of both intratumoral and extratumoral PB were found in overt PTC (>1 cm) than in papillary microcarcinomas (≤1 cm) (
P
< 0.001 and
P
= 0.015, respectively). Extratumoral PB were only identified in 48.9 % of 141 PTC with PB, and PTC with extratumoral PB showed higher incidences of tumor multifocality, extrathyroidal extension, and nodal metastasis compared to PTC with intratumoral PB (
P
= 0.014,
P
= 0.005 and
P
= 0.001, respectively). Ultrasonographic intratumoral calcification corresponded to clusters of intratumoral PB (
P
< 0.001) and was associated with nodal metastasis (
P
= 0.026).
Conclusions
The findings of the present study suggest that the presence of PB may be a useful prognostic indicator of aggressive PTC behaviors. In addition, confirmation of ultrasonographic intratumoral calcification would be a useful decision-making criterion when determining the need for preoperative or intraoperative surveillance of nodal metastasis.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-013-2107-5</identifier><identifier>PMID: 23716027</identifier><language>eng</language><publisher>Boston: Springer US</publisher><subject>Abdominal Surgery ; Adult ; Aggressive behavior ; Biomarkers, Tumor - genetics ; BRAFV600E Mutation ; Calcinosis - diagnostic imaging ; Calcinosis - etiology ; Carcinoma - diagnostic imaging ; Carcinoma - genetics ; Carcinoma - pathology ; Carcinoma - surgery ; Carcinoma, Papillary ; Cardiac Surgery ; Decision Support Techniques ; Extrathyroidal Extension ; Female ; General Surgery ; Humans ; Lateral Lymph Node Metastasis ; Logistic Models ; Lymphatic Metastasis ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Multivariate Analysis ; Neck Dissection ; Neoplasm Invasiveness ; Papillary Thyroid Carcinoma ; Prognosis ; Proto-Oncogene Proteins B-raf - genetics ; Surgery ; Thoracic Surgery ; Thyroid Cancer, Papillary ; Thyroid Neoplasms - diagnostic imaging ; Thyroid Neoplasms - genetics ; Thyroid Neoplasms - pathology ; Thyroid Neoplasms - surgery ; Thyroidectomy ; Tumor Burden ; Tumor Multifocality ; Ultrasonography ; Vascular Surgery</subject><ispartof>World journal of surgery, 2013-10, Vol.37 (10), p.2330-2335</ispartof><rights>Société Internationale de Chirurgie 2013</rights><rights>2013 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4552-be495368c5b68e55429590d8953c502d606e6365fe424a3a64e0a7ee6e6b88023</citedby><cites>FETCH-LOGICAL-c4552-be495368c5b68e55429590d8953c502d606e6365fe424a3a64e0a7ee6e6b88023</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-013-2107-5$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-013-2107-5$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,41488,42557,45574,45575,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23716027$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Pyo, Jung-Soo</creatorcontrib><creatorcontrib>Kang, Guhyun</creatorcontrib><creatorcontrib>Kim, Dong-Hoon</creatorcontrib><creatorcontrib>Park, Chanheun</creatorcontrib><creatorcontrib>Kim, Joo Heon</creatorcontrib><creatorcontrib>Sohn, Jin Hee</creatorcontrib><title>The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Background
Although psammoma bodies (PB) are found in up to 50 % of papillary thyroid carcinomas (PTC), their clinicopathological significance remains uncertain. The aim of the present study was to determine the clinicopathological significance of PB and the correlation between PB and ultrasonographic intratumoral calcification in PTC.
Methods
The clinicopathological parameters, ultrasonographic calcifications, and the presence of PB were evaluated in 258 surgically resected conventional PTC.
Results
Psammoma bodies were found in 141 of 258 PTC (54.7 %). The presence of PB was significantly correlated with tumor multifocality, extrathyroidal extension, and lymph node metastasis (
P
= 0.009,
P
= 0.004, and
P
< 0.001, respectively), but not with the BRAF
V600E
mutation. Higher incidences of both intratumoral and extratumoral PB were found in overt PTC (>1 cm) than in papillary microcarcinomas (≤1 cm) (
P
< 0.001 and
P
= 0.015, respectively). Extratumoral PB were only identified in 48.9 % of 141 PTC with PB, and PTC with extratumoral PB showed higher incidences of tumor multifocality, extrathyroidal extension, and nodal metastasis compared to PTC with intratumoral PB (
P
= 0.014,
P
= 0.005 and
P
= 0.001, respectively). Ultrasonographic intratumoral calcification corresponded to clusters of intratumoral PB (
P
< 0.001) and was associated with nodal metastasis (
P
= 0.026).
Conclusions
The findings of the present study suggest that the presence of PB may be a useful prognostic indicator of aggressive PTC behaviors. In addition, confirmation of ultrasonographic intratumoral calcification would be a useful decision-making criterion when determining the need for preoperative or intraoperative surveillance of nodal metastasis.</description><subject>Abdominal Surgery</subject><subject>Adult</subject><subject>Aggressive behavior</subject><subject>Biomarkers, Tumor - genetics</subject><subject>BRAFV600E Mutation</subject><subject>Calcinosis - diagnostic imaging</subject><subject>Calcinosis - etiology</subject><subject>Carcinoma - diagnostic imaging</subject><subject>Carcinoma - genetics</subject><subject>Carcinoma - pathology</subject><subject>Carcinoma - surgery</subject><subject>Carcinoma, Papillary</subject><subject>Cardiac Surgery</subject><subject>Decision Support Techniques</subject><subject>Extrathyroidal Extension</subject><subject>Female</subject><subject>General Surgery</subject><subject>Humans</subject><subject>Lateral Lymph Node Metastasis</subject><subject>Logistic Models</subject><subject>Lymphatic Metastasis</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Multivariate Analysis</subject><subject>Neck Dissection</subject><subject>Neoplasm Invasiveness</subject><subject>Papillary Thyroid Carcinoma</subject><subject>Prognosis</subject><subject>Proto-Oncogene Proteins B-raf - genetics</subject><subject>Surgery</subject><subject>Thoracic Surgery</subject><subject>Thyroid Cancer, Papillary</subject><subject>Thyroid Neoplasms - diagnostic imaging</subject><subject>Thyroid Neoplasms - genetics</subject><subject>Thyroid Neoplasms - pathology</subject><subject>Thyroid Neoplasms - surgery</subject><subject>Thyroidectomy</subject><subject>Tumor Burden</subject><subject>Tumor Multifocality</subject><subject>Ultrasonography</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><recordid>eNqNkU-LFDEQxRtR3HH1A3iRgBcvrZW_nT66g6srCw46i8eQSVfPZOlOxmRaGfzyZuhVRBA9JRS_93hVr6qeUnhJAZpXGYApXQPlNaPQ1PJetaCCs5pxxu9XC-BKlD_lZ9WjnG8BaKNAPazOGG-oAtYsqu_rHZJVitsQ88E78hEH_GqDQxJ7ssp2HONoyUXsPGZiQ0duhkOyOYa4TXa_K4qrUAaHaYzJDmRpB-d77-zBx5CJD2Rl934YbDqS9e6You8Kk5wPxfZx9aC3Q8Ynd-95dXP5Zr18V19_eHu1fH1dOyElqzcoWsmVdnKjNEopWCtb6HQZOgmsKyuh4kr2KJiw3CqBYBvEMt1oDYyfVy9m332KXybMBzP67LCkChinbKhomQItmvY_UKabhmstCvr8D_Q2TimURQrFBWUglCoUnSmXYs4Je7NPfiznMBTMqUQzl2hKieZUopFF8-zOedqM2P1S_GytAO0MfPMDHv_taD6__3RxCUqy0zHYrM1FFraYfov910Q_AEXSt2I</recordid><startdate>201310</startdate><enddate>201310</enddate><creator>Pyo, Jung-Soo</creator><creator>Kang, Guhyun</creator><creator>Kim, Dong-Hoon</creator><creator>Park, Chanheun</creator><creator>Kim, Joo Heon</creator><creator>Sohn, Jin Hee</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope><scope>7QP</scope></search><sort><creationdate>201310</creationdate><title>The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma</title><author>Pyo, Jung-Soo ; Kang, Guhyun ; Kim, Dong-Hoon ; Park, Chanheun ; Kim, Joo Heon ; Sohn, Jin Hee</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4552-be495368c5b68e55429590d8953c502d606e6365fe424a3a64e0a7ee6e6b88023</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Abdominal Surgery</topic><topic>Adult</topic><topic>Aggressive behavior</topic><topic>Biomarkers, Tumor - genetics</topic><topic>BRAFV600E Mutation</topic><topic>Calcinosis - diagnostic imaging</topic><topic>Calcinosis - etiology</topic><topic>Carcinoma - diagnostic imaging</topic><topic>Carcinoma - genetics</topic><topic>Carcinoma - pathology</topic><topic>Carcinoma - surgery</topic><topic>Carcinoma, Papillary</topic><topic>Cardiac Surgery</topic><topic>Decision Support Techniques</topic><topic>Extrathyroidal Extension</topic><topic>Female</topic><topic>General Surgery</topic><topic>Humans</topic><topic>Lateral Lymph Node Metastasis</topic><topic>Logistic Models</topic><topic>Lymphatic Metastasis</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Multivariate Analysis</topic><topic>Neck Dissection</topic><topic>Neoplasm Invasiveness</topic><topic>Papillary Thyroid Carcinoma</topic><topic>Prognosis</topic><topic>Proto-Oncogene Proteins B-raf - genetics</topic><topic>Surgery</topic><topic>Thoracic Surgery</topic><topic>Thyroid Cancer, Papillary</topic><topic>Thyroid Neoplasms - diagnostic imaging</topic><topic>Thyroid Neoplasms - genetics</topic><topic>Thyroid Neoplasms - pathology</topic><topic>Thyroid Neoplasms - surgery</topic><topic>Thyroidectomy</topic><topic>Tumor Burden</topic><topic>Tumor Multifocality</topic><topic>Ultrasonography</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Pyo, Jung-Soo</creatorcontrib><creatorcontrib>Kang, Guhyun</creatorcontrib><creatorcontrib>Kim, Dong-Hoon</creatorcontrib><creatorcontrib>Park, Chanheun</creatorcontrib><creatorcontrib>Kim, Joo Heon</creatorcontrib><creatorcontrib>Sohn, Jin Hee</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><collection>Calcium & Calcified Tissue Abstracts</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Pyo, Jung-Soo</au><au>Kang, Guhyun</au><au>Kim, Dong-Hoon</au><au>Park, Chanheun</au><au>Kim, Joo Heon</au><au>Sohn, Jin Hee</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2013-10</date><risdate>2013</risdate><volume>37</volume><issue>10</issue><spage>2330</spage><epage>2335</epage><pages>2330-2335</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Background
Although psammoma bodies (PB) are found in up to 50 % of papillary thyroid carcinomas (PTC), their clinicopathological significance remains uncertain. The aim of the present study was to determine the clinicopathological significance of PB and the correlation between PB and ultrasonographic intratumoral calcification in PTC.
Methods
The clinicopathological parameters, ultrasonographic calcifications, and the presence of PB were evaluated in 258 surgically resected conventional PTC.
Results
Psammoma bodies were found in 141 of 258 PTC (54.7 %). The presence of PB was significantly correlated with tumor multifocality, extrathyroidal extension, and lymph node metastasis (
P
= 0.009,
P
= 0.004, and
P
< 0.001, respectively), but not with the BRAF
V600E
mutation. Higher incidences of both intratumoral and extratumoral PB were found in overt PTC (>1 cm) than in papillary microcarcinomas (≤1 cm) (
P
< 0.001 and
P
= 0.015, respectively). Extratumoral PB were only identified in 48.9 % of 141 PTC with PB, and PTC with extratumoral PB showed higher incidences of tumor multifocality, extrathyroidal extension, and nodal metastasis compared to PTC with intratumoral PB (
P
= 0.014,
P
= 0.005 and
P
= 0.001, respectively). Ultrasonographic intratumoral calcification corresponded to clusters of intratumoral PB (
P
< 0.001) and was associated with nodal metastasis (
P
= 0.026).
Conclusions
The findings of the present study suggest that the presence of PB may be a useful prognostic indicator of aggressive PTC behaviors. In addition, confirmation of ultrasonographic intratumoral calcification would be a useful decision-making criterion when determining the need for preoperative or intraoperative surveillance of nodal metastasis.</abstract><cop>Boston</cop><pub>Springer US</pub><pmid>23716027</pmid><doi>10.1007/s00268-013-2107-5</doi><tpages>6</tpages></addata></record> |
| fulltext | fulltext |
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| ispartof | World journal of surgery, 2013-10, Vol.37 (10), p.2330-2335 |
| issn | 0364-2313 1432-2323 |
| language | eng |
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| source | MEDLINE; Wiley Journals; SpringerLink Journals |
| subjects | Abdominal Surgery Adult Aggressive behavior Biomarkers, Tumor - genetics BRAFV600E Mutation Calcinosis - diagnostic imaging Calcinosis - etiology Carcinoma - diagnostic imaging Carcinoma - genetics Carcinoma - pathology Carcinoma - surgery Carcinoma, Papillary Cardiac Surgery Decision Support Techniques Extrathyroidal Extension Female General Surgery Humans Lateral Lymph Node Metastasis Logistic Models Lymphatic Metastasis Male Medicine Medicine & Public Health Middle Aged Multivariate Analysis Neck Dissection Neoplasm Invasiveness Papillary Thyroid Carcinoma Prognosis Proto-Oncogene Proteins B-raf - genetics Surgery Thoracic Surgery Thyroid Cancer, Papillary Thyroid Neoplasms - diagnostic imaging Thyroid Neoplasms - genetics Thyroid Neoplasms - pathology Thyroid Neoplasms - surgery Thyroidectomy Tumor Burden Tumor Multifocality Ultrasonography Vascular Surgery |
| title | The Prognostic Relevance of Psammoma Bodies and Ultrasonographic Intratumoral Calcifications in Papillary Thyroid Carcinoma |
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