Mechanistic insights into 1‐deoxy‐d‐xylulose 5‐phosphate reductoisomerase, a key enzyme of the MEP terpenoid biosynthetic pathway

The binding mode of 1‐deoxy‐d‐xylulose 5‐phosphate (DXP) to 1‐deoxy‐d‐xylulose 5‐phosphate reductoisomerase (DXR) (EC 1.1.1.267) from Escherichia coli was investigated via 18O isotope exchange experiments and determination of the kinetic parameters of the reaction. The results support a C3–C4 substr...

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Veröffentlicht in:	The FEBS journal 2013-11, Vol.280 (22), p.5896-5905
Hauptverfasser:	Li, Heng, Tian, Jie, Sun, Wei, Qin, Wei, Gao, Wen‐Yun
Format:	Artikel
Sprache:	eng
Schlagworte:	1‐deoxy‐d‐xylulose 5‐phosphate 1‐deoxy‐d‐xylulose 5‐phosphate reductoisomerase Aldose-Ketose Isomerases - chemistry Aldose-Ketose Isomerases - metabolism binding mode Biosynthesis Biosynthetic Pathways catalytic cycle E coli Enzymes Erythritol - analogs & derivatives Erythritol - biosynthesis Erythritol - chemistry Escherichia coli Escherichia coli - enzymology Escherichia coli Proteins - chemistry Escherichia coli Proteins - metabolism Kinetics Magnetic Resonance Spectroscopy MEP pathway Models, Biological Molecular Structure Pentosephosphates - chemistry Pentosephosphates - metabolism Reaction kinetics Spectrometry, Mass, Electrospray Ionization Sugar Phosphates - biosynthesis Sugar Phosphates - chemistry Terpenes - chemistry Terpenes - metabolism
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