Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes
Objective: When rectal bleeding occurs in an otherwise asymptomatic child, it can be classified as isolated rectal bleeding (IRB). Among the different etiologies suggested for IRB, one of the most common is a hypersensitivity reaction of the bowel mucosa to digested antigens. The objective of this s...
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| Veröffentlicht in: | Journal of perinatology 2014-01, Vol.34 (1), p.39-42 |
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| creator | Reiter, O Morag, I Mazkereth, R Strauss, T Maayan-Metzger, A |
| description | Objective:
When rectal bleeding occurs in an otherwise asymptomatic child, it can be classified as isolated rectal bleeding (IRB). Among the different etiologies suggested for IRB, one of the most common is a hypersensitivity reaction of the bowel mucosa to digested antigens. The objective of this study was to assess the long-term outcomes and the risk of developing hypersensitivity syndromes among infants following an IRB event.
Study Design:
A historical prospective comparative study was carried out. The study compared 77 infants who were born at the Sheba Medical Center in Israel during the period 2002 to 2009 and who experienced a neonatal IRB event to 77 infants with the same gestational age, but without IRB. Data were obtained from hospital records and from phone interviews with the parents regarding hypersensitivity syndrome between the ages of 3 and 10 years.
Result:
The IRB group was not at an increased risk of developing a hypersensitivity syndrome or gastrointestinal symptoms compared to the control group. Longer duration of breast-feeding was found to be related to a lower incidence of hypersensitivity symptoms.
Conclusion:
An IRB event in the neonatal period does not increase the risk of developing hypersensitivity syndromes or food allergies during childhood. |
| doi_str_mv | 10.1038/jp.2013.129 |
| format | Article |
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When rectal bleeding occurs in an otherwise asymptomatic child, it can be classified as isolated rectal bleeding (IRB). Among the different etiologies suggested for IRB, one of the most common is a hypersensitivity reaction of the bowel mucosa to digested antigens. The objective of this study was to assess the long-term outcomes and the risk of developing hypersensitivity syndromes among infants following an IRB event.
Study Design:
A historical prospective comparative study was carried out. The study compared 77 infants who were born at the Sheba Medical Center in Israel during the period 2002 to 2009 and who experienced a neonatal IRB event to 77 infants with the same gestational age, but without IRB. Data were obtained from hospital records and from phone interviews with the parents regarding hypersensitivity syndrome between the ages of 3 and 10 years.
Result:
The IRB group was not at an increased risk of developing a hypersensitivity syndrome or gastrointestinal symptoms compared to the control group. Longer duration of breast-feeding was found to be related to a lower incidence of hypersensitivity symptoms.
Conclusion:
An IRB event in the neonatal period does not increase the risk of developing hypersensitivity syndromes or food allergies during childhood.</description><identifier>ISSN: 0743-8346</identifier><identifier>EISSN: 1476-5543</identifier><identifier>DOI: 10.1038/jp.2013.129</identifier><identifier>PMID: 24113397</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>692/420 ; 692/699/1503/197 ; 692/699/249/2510/9 ; 692/700/1720 ; Abdomen ; Allergic reaction ; Allergy ; Antigens ; Asthma ; Asthma - etiology ; Asymptomatic ; Babies ; Birth Weight ; Breast Feeding ; Case-Control Studies ; Children & youth ; Complications and side effects ; Dermatitis ; Female ; Food allergies ; Food Hypersensitivity - etiology ; Gastrointestinal bleeding ; Gastrointestinal Hemorrhage - complications ; Gestational Age ; Hay fever ; Health aspects ; Hospitals ; Humans ; Hypersensitivity - etiology ; Infant, Newborn ; Infant, Premature ; Infant, Premature, Diseases ; Infants (Newborn) ; Male ; Medicine ; Medicine & Public Health ; Neonatal care ; original-article ; Pediatric Surgery ; Pediatrics ; Prospective Studies ; Rectum ; Rhinitis ; Risk Factors</subject><ispartof>Journal of perinatology, 2014-01, Vol.34 (1), p.39-42</ispartof><rights>Nature America, Inc. 2014</rights><rights>COPYRIGHT 2014 Nature Publishing Group</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c522t-746dda5a32400afaf93a073ca5c4c11087f8f7fea0ebff9c71b214974891c15c3</citedby><cites>FETCH-LOGICAL-c522t-746dda5a32400afaf93a073ca5c4c11087f8f7fea0ebff9c71b214974891c15c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1038/jp.2013.129$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1038/jp.2013.129$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24113397$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Reiter, O</creatorcontrib><creatorcontrib>Morag, I</creatorcontrib><creatorcontrib>Mazkereth, R</creatorcontrib><creatorcontrib>Strauss, T</creatorcontrib><creatorcontrib>Maayan-Metzger, A</creatorcontrib><title>Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes</title><title>Journal of perinatology</title><addtitle>J Perinatol</addtitle><addtitle>J Perinatol</addtitle><description>Objective:
When rectal bleeding occurs in an otherwise asymptomatic child, it can be classified as isolated rectal bleeding (IRB). Among the different etiologies suggested for IRB, one of the most common is a hypersensitivity reaction of the bowel mucosa to digested antigens. The objective of this study was to assess the long-term outcomes and the risk of developing hypersensitivity syndromes among infants following an IRB event.
Study Design:
A historical prospective comparative study was carried out. The study compared 77 infants who were born at the Sheba Medical Center in Israel during the period 2002 to 2009 and who experienced a neonatal IRB event to 77 infants with the same gestational age, but without IRB. Data were obtained from hospital records and from phone interviews with the parents regarding hypersensitivity syndrome between the ages of 3 and 10 years.
Result:
The IRB group was not at an increased risk of developing a hypersensitivity syndrome or gastrointestinal symptoms compared to the control group. Longer duration of breast-feeding was found to be related to a lower incidence of hypersensitivity symptoms.
Conclusion:
An IRB event in the neonatal period does not increase the risk of developing hypersensitivity syndromes or food allergies during childhood.</description><subject>692/420</subject><subject>692/699/1503/197</subject><subject>692/699/249/2510/9</subject><subject>692/700/1720</subject><subject>Abdomen</subject><subject>Allergic reaction</subject><subject>Allergy</subject><subject>Antigens</subject><subject>Asthma</subject><subject>Asthma - etiology</subject><subject>Asymptomatic</subject><subject>Babies</subject><subject>Birth Weight</subject><subject>Breast Feeding</subject><subject>Case-Control Studies</subject><subject>Children & youth</subject><subject>Complications and side effects</subject><subject>Dermatitis</subject><subject>Female</subject><subject>Food allergies</subject><subject>Food Hypersensitivity - etiology</subject><subject>Gastrointestinal bleeding</subject><subject>Gastrointestinal Hemorrhage - complications</subject><subject>Gestational Age</subject><subject>Hay fever</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Humans</subject><subject>Hypersensitivity - etiology</subject><subject>Infant, Newborn</subject><subject>Infant, Premature</subject><subject>Infant, Premature, Diseases</subject><subject>Infants (Newborn)</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Neonatal care</subject><subject>original-article</subject><subject>Pediatric Surgery</subject><subject>Pediatrics</subject><subject>Prospective Studies</subject><subject>Rectum</subject><subject>Rhinitis</subject><subject>Risk Factors</subject><issn>0743-8346</issn><issn>1476-5543</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqN0s9rFDEUB_Agit1WT95lQBBBZ83PycyxFKvCohc9h2zmZTfrTDImmcL-92bYqq30IDmE5H3y4JEvQi8IXhPM2veHaU0xYWtCu0doRbhsaiE4e4xWWHJWt4w3Z-g8pQPGS1E-RWeUE8JYJ1do8wWC11kPlUth0Bn6KoJZztsBoHd-V2nfV3kPVXTpRxVstT9OEBP45LK7cflYpaPvYxghPUNPrB4SPL_dL9D36w_frj7Vm68fP19dbmojKM215E3fa6EZ5Rhrq23HNJbMaGG4IQS30rZWWtAYttZ2RpItJbyTvO2IIcKwC_Tm1HeK4ecMKavRJQPDoD2EOamCaYMbQrr_oVgKKltW6Kt_6CHM0ZdBipJEcE47-lft9ADKeRty1GZpqi6ZkKKjgpOi1g-osnoYnQkerCv39x68vvNgD3rI-_Ihc3bBp_vw7QmaGFKKYNUU3ajjURGsljyow6SWPKiSh6Jf3s40b0fo_9jfASjg3QmkUvI7iHeGfqDfL7uEu4Q</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Reiter, O</creator><creator>Morag, I</creator><creator>Mazkereth, R</creator><creator>Strauss, T</creator><creator>Maayan-Metzger, A</creator><general>Nature Publishing Group US</general><general>Nature Publishing Group</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QG</scope><scope>7QL</scope><scope>7RV</scope><scope>7T5</scope><scope>7T7</scope><scope>7U9</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FD</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AN0</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>C1K</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7N</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20140101</creationdate><title>Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes</title><author>Reiter, O ; Morag, I ; Mazkereth, R ; Strauss, T ; Maayan-Metzger, A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c522t-746dda5a32400afaf93a073ca5c4c11087f8f7fea0ebff9c71b214974891c15c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>692/420</topic><topic>692/699/1503/197</topic><topic>692/699/249/2510/9</topic><topic>692/700/1720</topic><topic>Abdomen</topic><topic>Allergic reaction</topic><topic>Allergy</topic><topic>Antigens</topic><topic>Asthma</topic><topic>Asthma - 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Academic</collection><jtitle>Journal of perinatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Reiter, O</au><au>Morag, I</au><au>Mazkereth, R</au><au>Strauss, T</au><au>Maayan-Metzger, A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes</atitle><jtitle>Journal of perinatology</jtitle><stitle>J Perinatol</stitle><addtitle>J Perinatol</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>34</volume><issue>1</issue><spage>39</spage><epage>42</epage><pages>39-42</pages><issn>0743-8346</issn><eissn>1476-5543</eissn><abstract>Objective:
When rectal bleeding occurs in an otherwise asymptomatic child, it can be classified as isolated rectal bleeding (IRB). Among the different etiologies suggested for IRB, one of the most common is a hypersensitivity reaction of the bowel mucosa to digested antigens. The objective of this study was to assess the long-term outcomes and the risk of developing hypersensitivity syndromes among infants following an IRB event.
Study Design:
A historical prospective comparative study was carried out. The study compared 77 infants who were born at the Sheba Medical Center in Israel during the period 2002 to 2009 and who experienced a neonatal IRB event to 77 infants with the same gestational age, but without IRB. Data were obtained from hospital records and from phone interviews with the parents regarding hypersensitivity syndrome between the ages of 3 and 10 years.
Result:
The IRB group was not at an increased risk of developing a hypersensitivity syndrome or gastrointestinal symptoms compared to the control group. Longer duration of breast-feeding was found to be related to a lower incidence of hypersensitivity symptoms.
Conclusion:
An IRB event in the neonatal period does not increase the risk of developing hypersensitivity syndromes or food allergies during childhood.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>24113397</pmid><doi>10.1038/jp.2013.129</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | 692/420 692/699/1503/197 692/699/249/2510/9 692/700/1720 Abdomen Allergic reaction Allergy Antigens Asthma Asthma - etiology Asymptomatic Babies Birth Weight Breast Feeding Case-Control Studies Children & youth Complications and side effects Dermatitis Female Food allergies Food Hypersensitivity - etiology Gastrointestinal bleeding Gastrointestinal Hemorrhage - complications Gestational Age Hay fever Health aspects Hospitals Humans Hypersensitivity - etiology Infant, Newborn Infant, Premature Infant, Premature, Diseases Infants (Newborn) Male Medicine Medicine & Public Health Neonatal care original-article Pediatric Surgery Pediatrics Prospective Studies Rectum Rhinitis Risk Factors |
| title | Neonatal isolated rectal bleeding and the risk of hypersensitivity syndromes |
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