Soy flour nanoparticles for controlled drug delivery: effect of crosslinker and montmorillonite (MMT)

Soy flour nanoparticles for controlled drug delivery: effect of crosslinker and montmorillonite (MMT)

Soy flour (SF)-Montmorillonite (MMT) nanoparticles crosslinked with glutaraldehyde (GA) have been made and used as a carrier for isoniazid. The nanoparticles have been characterized by fourier transmission infra-red spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM)...

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Veröffentlicht in:New journal of chemistry 2013-01, Vol.37 (12), p.3981-3990
Hauptverfasser: Banik, Nibedita, Iman, Murshid, Hussain, Anowar, Ramteke, Anand, Boruah, Ratan, Maji, Tarun K.
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Controlled release
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container_end_page 3990
container_issue 12
container_start_page 3981
container_title New journal of chemistry
container_volume 37
creator Banik, Nibedita
Iman, Murshid
Hussain, Anowar
Ramteke, Anand
Boruah, Ratan
Maji, Tarun K.
description Soy flour (SF)-Montmorillonite (MMT) nanoparticles crosslinked with glutaraldehyde (GA) have been made and used as a carrier for isoniazid. The nanoparticles have been characterized by fourier transmission infra-red spectroscopy (FTIR), X-ray diffractometry (XRD), scanning electron microscopy (SEM) and transmission emission microscopy (TEM). The effects of MMT and glutaraldehyde on the nanoparticles have been assessed with regard to swelling, encapsulation efficiency and consequently, the release of isoniazid in different mediums. The drug release mechanism has been studied for different time periods by UV-Vis spectroscopy. Cytotoxicity testing has been performed by MTT assay analysis. The results imply that the nanoparticles can be exploited as a potential drug carrier for controlled release applications.
doi_str_mv 10.1039/c3nj00480e
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source Royal Society Of Chemistry Journals 2008-; Alma/SFX Local Collection
subjects Controlled release
title Soy flour nanoparticles for controlled drug delivery: effect of crosslinker and montmorillonite (MMT)
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