Total synthesis and further characterization of the .gamma.-carboxyglutamate-containing "sleeper" peptide from Conus geographus venom

The total synthesis of the Gla-containing "sleeper" peptide (Gly-Glu-Gla-Gla-Leu-Gln-Gla-Asn-Gln-Gla-Leu-Ile-Arg-Gla-Lys-Ser-Asn-NH2 ) from Conus geographus is described. A new strategy for the synthesis of acid-sensitive peptide amides was developed, which allowed complete deprotection an...

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Veröffentlicht in:	Biochemistry (Easton) 1987-12, Vol.26 (26), p.8508-8512
Hauptverfasser:	Rivier, Jean, Galyean, Robert, Simon, Lajos, Cruz, Lourdes J, Olivera, Baldomero M, Gray, William R
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Carboxyglutamic Acid Amino Acid Sequence Aminoacids, peptides. Hormones. Neuropeptides Analytical, structural and metabolic biochemistry Animals Biological and medical sciences biological poisons calcium Chromatography, High Pressure Liquid Conotoxins Conus geographus Fundamental and applied biological sciences. Psychology Indicators and Reagents Marine Mice Mollusk Venoms - chemical synthesis Mollusk Venoms - pharmacology peptides Protein Conformation Proteins Sleep - drug effects sleeper peptide
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