Use of fosfomycin disks for isolation of diphtheroids
A fosfomycin disk (200 micrograms) placed on blood agar was used to select diphtheroids from clinical specimens. All Corynebacterium type strains tested, representing ten different groups of diphtheroids, and 150 toxigenic strains of Corynebacterium diphtheriae from different outbreaks, overgrew the...
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| Veröffentlicht in: | European journal of clinical microbiology & infectious diseases 1988-04, Vol.7 (2), p.190-193 |
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| container_title | European journal of clinical microbiology & infectious diseases |
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| creator | Wirsing von Koenig, C H Krech, T Finger, H Bergmann, M |
| description | A fosfomycin disk (200 micrograms) placed on blood agar was used to select diphtheroids from clinical specimens. All Corynebacterium type strains tested, representing ten different groups of diphtheroids, and 150 toxigenic strains of Corynebacterium diphtheriae from different outbreaks, overgrew the fosfomycin disk, while other aerobic gram-positive rods had a large inhibition zone. The method increased the rate of isolation of diphtheroids in 1267 clinical specimens fivefold, from 1.4% to 7.6%, especially when the diphtheroids were found concomitantly with other bacteria. Overgrowth of the disk by other microorganisms occurred in 11% of the samples tested, but such microorganisms could easily be distinguished by culture morphology or Gram stain. Fosfomycin disks provide a simple, highly sensitive but not very specific aid for isolation of Corynebacterium diphtheriae and diphtheroids from clinical specimens. |
| doi_str_mv | 10.1007/BF01963079 |
| format | Article |
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All Corynebacterium type strains tested, representing ten different groups of diphtheroids, and 150 toxigenic strains of Corynebacterium diphtheriae from different outbreaks, overgrew the fosfomycin disk, while other aerobic gram-positive rods had a large inhibition zone. The method increased the rate of isolation of diphtheroids in 1267 clinical specimens fivefold, from 1.4% to 7.6%, especially when the diphtheroids were found concomitantly with other bacteria. Overgrowth of the disk by other microorganisms occurred in 11% of the samples tested, but such microorganisms could easily be distinguished by culture morphology or Gram stain. 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All Corynebacterium type strains tested, representing ten different groups of diphtheroids, and 150 toxigenic strains of Corynebacterium diphtheriae from different outbreaks, overgrew the fosfomycin disk, while other aerobic gram-positive rods had a large inhibition zone. The method increased the rate of isolation of diphtheroids in 1267 clinical specimens fivefold, from 1.4% to 7.6%, especially when the diphtheroids were found concomitantly with other bacteria. Overgrowth of the disk by other microorganisms occurred in 11% of the samples tested, but such microorganisms could easily be distinguished by culture morphology or Gram stain. Fosfomycin disks provide a simple, highly sensitive but not very specific aid for isolation of Corynebacterium diphtheriae and diphtheroids from clinical specimens.</description><subject>Corynebacterium</subject><subject>Corynebacterium - drug effects</subject><subject>Corynebacterium - growth & development</subject><subject>Corynebacterium - isolation & purification</subject><subject>Corynebacterium diphtheriae</subject><subject>Corynebacterium diphtheriae - drug effects</subject><subject>Corynebacterium diphtheriae - growth & development</subject><subject>Corynebacterium diphtheriae - isolation & purification</subject><subject>Culture Media</subject><subject>Fosfomycin - pharmacology</subject><subject>Humans</subject><issn>0934-9723</issn><issn>1435-4373</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>1988</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpFkM9Lw0AQhRdRaq1evAs5eRCiOzubbPeoxapQ8GLPIdkfdDXp1p300P--KS16Gnh8vDd8jN0CfwTO1dPLnIMukSt9xsYgscglKjxnY65R5loJvGRXRN98gKdKjdgIAaUAMWbFklwWfeYj-djtTFhnNtAPDUHKAsW27kNcHwgbNqt-5VIMlq7Zha9bcjenO2HL-evX7D1ffL59zJ4XuRkG-hxLaa1UirspH3YbMB5K5ZWXjoOyggsjlFFa1Fp4ADttsJDDz2CaGr0EnLD7Y-8mxd-to77qAhnXtvXaxS1VIDWUUBzAhyNoUiRKzlebFLo67Srg1cFR9e9ogO9Ordumc_YPPUnBPY94XyM</recordid><startdate>19880401</startdate><enddate>19880401</enddate><creator>Wirsing von Koenig, C H</creator><creator>Krech, T</creator><creator>Finger, H</creator><creator>Bergmann, M</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QL</scope><scope>C1K</scope></search><sort><creationdate>19880401</creationdate><title>Use of fosfomycin disks for isolation of diphtheroids</title><author>Wirsing von Koenig, C H ; Krech, T ; Finger, H ; Bergmann, M</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c313t-364dd4770e80877b1cf167f7f4e017d202c27c792a92f11d8b3540931cba3f413</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>1988</creationdate><topic>Corynebacterium</topic><topic>Corynebacterium - drug effects</topic><topic>Corynebacterium - growth & development</topic><topic>Corynebacterium - isolation & purification</topic><topic>Corynebacterium diphtheriae</topic><topic>Corynebacterium diphtheriae - drug effects</topic><topic>Corynebacterium diphtheriae - growth & development</topic><topic>Corynebacterium diphtheriae - isolation & purification</topic><topic>Culture Media</topic><topic>Fosfomycin - pharmacology</topic><topic>Humans</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wirsing von Koenig, C H</creatorcontrib><creatorcontrib>Krech, T</creatorcontrib><creatorcontrib>Finger, H</creatorcontrib><creatorcontrib>Bergmann, M</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Bacteriology Abstracts (Microbiology B)</collection><collection>Environmental Sciences and Pollution Management</collection><jtitle>European journal of clinical microbiology & infectious diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wirsing von Koenig, C H</au><au>Krech, T</au><au>Finger, H</au><au>Bergmann, M</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of fosfomycin disks for isolation of diphtheroids</atitle><jtitle>European journal of clinical microbiology & infectious diseases</jtitle><addtitle>Eur J Clin Microbiol Infect Dis</addtitle><date>1988-04-01</date><risdate>1988</risdate><volume>7</volume><issue>2</issue><spage>190</spage><epage>193</epage><pages>190-193</pages><issn>0934-9723</issn><eissn>1435-4373</eissn><abstract>A fosfomycin disk (200 micrograms) placed on blood agar was used to select diphtheroids from clinical specimens. 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| identifier | ISSN: 0934-9723 |
| ispartof | European journal of clinical microbiology & infectious diseases, 1988-04, Vol.7 (2), p.190-193 |
| issn | 0934-9723 1435-4373 |
| language | eng |
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| source | MEDLINE; Springer Nature - Complete Springer Journals |
| subjects | Corynebacterium Corynebacterium - drug effects Corynebacterium - growth & development Corynebacterium - isolation & purification Corynebacterium diphtheriae Corynebacterium diphtheriae - drug effects Corynebacterium diphtheriae - growth & development Corynebacterium diphtheriae - isolation & purification Culture Media Fosfomycin - pharmacology Humans |
| title | Use of fosfomycin disks for isolation of diphtheroids |
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