Characterization of free radical-induced base damage in DNA at biologically relevant levels

DNA damage induced by oxygen radicals, e.g., hydroxyl radicals generated in living cells either by cellular metabolism or external agents such as ionizing radiations, appears to play an important role in mutagenesis, carcinogenesis, and aging. Elucidation of the chemical nature of such DNA lesions a...

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Veröffentlicht in:	Anal. Biochem.; (United States) 1986-07, Vol.156 (1), p.182-188
Hauptverfasser:	Dizdaroglu, Miral, Bergtold, David S.
Format:	Artikel
Sprache:	eng
Schlagworte:	560111 - Radiation Effects on Biochemicals- In Vitro- (-1987) Biological and medical sciences BIOLOGICAL RECOVERY BIOLOGICAL REPAIR characteristic ions CHEMICAL RADIATION EFFECTS CHEMICAL REACTIONS CHEMISTRY DECOMPOSITION DNA DNA - radiation effects DNA damage DNA REPAIR ELEMENTS Formates Free Radicals Fundamental and applied biological sciences. Psychology Gamma Rays Gas Chromatography-Mass Spectrometry - methods high sensitivity HYDROGEN HYDROGEN COMPOUNDS HYDROLYSIS HYDROXIDES Hydroxyl Radical ionizing radiation IONIZING RADIATIONS LYSIS Molecular and cellular biology Molecular genetics Mutagenesis. Repair NONMETALS NUCLEIC ACIDS ORGANIC COMPOUNDS OXYGEN COMPOUNDS RADIATION CHEMISTRY RADIATION EFFECTS RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT RADIATIONS RECOVERY REPAIR SOLVOLYSIS Trimethylsilyl Compounds - analysis
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