Elastin Haploinsufficiency Impedes the Progression of Arterial Calcification in MGP‐Deficient Mice

ABSTRACT Matrix gla protein (MGP) is a potent inhibitor of extracellular matrix (ECM) mineralization. MGP‐deficiency in humans leads to Keutel syndrome, a rare genetic disease hallmarked by abnormal soft tissue calcification. MGP‐deficient (Mgp–/–) mice show progressive deposition of hydroxyapatite...

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Veröffentlicht in:	Journal of bone and mineral research 2014-02, Vol.29 (2), p.327-337
Hauptverfasser:	Khavandgar, Zohreh, Roman, Hassem, Li, Jingjing, Lee, Sara, Vali, Hojatollah, Brinckmann, Juergen, Davis, Elaine C, Murshed, Monzur
Format:	Artikel
Sprache:	eng
Schlagworte:	Aging - genetics Aging - metabolism Aging - pathology Animals Antigens, Differentiation - genetics Antigens, Differentiation - metabolism Aorta, Thoracic - diagnostic imaging Aorta, Thoracic - metabolism Aorta, Thoracic - pathology Aorta, Thoracic - physiopathology Durapatite - metabolism ELASTIN Elastin - genetics Elastin - metabolism KEUTEL SYNDROME MATRIX GLA PROTEIN Mice Mice, Knockout Proteins - genetics Proteins - metabolism VASCULAR CALCIFICATION Vascular Calcification - diagnostic imaging Vascular Calcification - genetics Vascular Calcification - metabolism Vascular Calcification - pathology Vascular Calcification - physiopathology VASCULAR SMOOTH MUSCLE CELLS X-Ray Microtomography
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