Preparation, characterization and pharmacokinetics of Amoitone B-loaded long circulating nanostructured lipid carriers

•Emulsion–evaporation and low temperature-solidification method was used to prepare nanostructured lipid carriers.•High drug loading and sustained release were achieved by nanostructured lipid carriers.•Long circulation was realized by the modification of PEG.•Drug residence time in vivo was extende...

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Veröffentlicht in:	Colloids and surfaces, B, Biointerfaces B, Biointerfaces, 2014-02, Vol.114, p.255-260
Hauptverfasser:	Luan, Jingjing, Zhang, Dianrui, Hao, Leilei, Qi, Lisi, Liu, Xinquan, Guo, Hejian, Li, Caiyun, Guo, Yuanyuan, Li, Tingting, Zhang, Qiang, Zhai, Guangxi
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Intravenous Amoitone B Animals Drug Carriers - chemistry Drug Compounding In vitro release Lipids - chemistry Long circulation Nanostructured lipid carriers Nanostructures - chemistry Nanostructures - ultrastructure Particle Size Pharmacokinetics Phenylacetates - blood Phenylacetates - chemical synthesis Phenylacetates - chemistry Phenylacetates - pharmacokinetics Rabbits Static Electricity X-Ray Diffraction
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