Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma
Background Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR. Methods We investigated small airway function assessed by spirometry and impulse oscillometry, as well as...
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| Veröffentlicht in: | Allergy (Copenhagen) 2013-11, Vol.68 (11), p.1419-1426 |
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| container_title | Allergy (Copenhagen) |
| container_volume | 68 |
| creator | Boudewijn, I. M. Telenga, E. D. Wiel, E. Molen, T. Schiphof, L. ten Hacken, N. H. T. Postma, D. S. Berge, M. |
| description | Background
Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR.
Methods
We investigated small airway function assessed by spirometry and impulse oscillometry, as well as Borg dyspnea scores at baseline and during a methacholine provocation test in 15 subjects with asymptomatic BHR, 15 asthma patients, and 15 healthy controls.
Results
At baseline, small airway function (R5–R20 and X5) was comparable between subjects with asymptomatic BHR and healthy controls, whereas asthma patients showed small airway dysfunction as reflected by higher R5–R20 and lower X5 values. During methacholine provocation, small airway dysfunction was more severe in asthma patients than in subjects with asymptomatic BHR. Interestingly, a higher increase in small airway dysfunction during methacholine provocation was associated with a higher increase in Borg dyspnea scores in subjects with asymptomatic BHR, but not in asthma patients.
Conclusion
Subjects with asymptomatic BHR may experience fewer symptoms in daily life because they have less small airway dysfunction. |
| doi_str_mv | 10.1111/all.12242 |
| format | Article |
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Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR.
Methods
We investigated small airway function assessed by spirometry and impulse oscillometry, as well as Borg dyspnea scores at baseline and during a methacholine provocation test in 15 subjects with asymptomatic BHR, 15 asthma patients, and 15 healthy controls.
Results
At baseline, small airway function (R5–R20 and X5) was comparable between subjects with asymptomatic BHR and healthy controls, whereas asthma patients showed small airway dysfunction as reflected by higher R5–R20 and lower X5 values. During methacholine provocation, small airway dysfunction was more severe in asthma patients than in subjects with asymptomatic BHR. Interestingly, a higher increase in small airway dysfunction during methacholine provocation was associated with a higher increase in Borg dyspnea scores in subjects with asymptomatic BHR, but not in asthma patients.
Conclusion
Subjects with asymptomatic BHR may experience fewer symptoms in daily life because they have less small airway dysfunction.</description><identifier>ISSN: 0105-4538</identifier><identifier>EISSN: 1398-9995</identifier><identifier>DOI: 10.1111/all.12242</identifier><identifier>PMID: 24128343</identifier><language>eng</language><publisher>Denmark: Blackwell Publishing Ltd</publisher><subject>Adult ; Airway management ; Allergies ; Asthma ; Asthma - epidemiology ; Asthma - immunology ; Asthma - physiopathology ; asymptomatic bronchial hyperresponsiveness ; Asymptomatic Diseases - epidemiology ; Body Mass Index ; Bronchial Hyperreactivity - epidemiology ; Bronchial Hyperreactivity - immunology ; Bronchial Hyperreactivity - physiopathology ; Cross-Sectional Studies ; Female ; Humans ; Male ; Methacholine Chloride - administration & dosage ; Middle Aged ; Pulmonary Disease, Chronic Obstructive - epidemiology ; Randomized Controlled Trials as Topic - trends ; Respiratory system ; small airways ; Young Adult</subject><ispartof>Allergy (Copenhagen), 2013-11, Vol.68 (11), p.1419-1426</ispartof><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2013 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2013 John Wiley & Sons A/S</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4522-d53d55a84adfffe5eb12b74fa2636dd491e326ff14e923e5c2f3898279c6fb9c3</citedby><cites>FETCH-LOGICAL-c4522-d53d55a84adfffe5eb12b74fa2636dd491e326ff14e923e5c2f3898279c6fb9c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fall.12242$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fall.12242$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,1434,27929,27930,45579,45580,46414,46838</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24128343$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boudewijn, I. M.</creatorcontrib><creatorcontrib>Telenga, E. D.</creatorcontrib><creatorcontrib>Wiel, E.</creatorcontrib><creatorcontrib>Molen, T.</creatorcontrib><creatorcontrib>Schiphof, L.</creatorcontrib><creatorcontrib>ten Hacken, N. H. T.</creatorcontrib><creatorcontrib>Postma, D. S.</creatorcontrib><creatorcontrib>Berge, M.</creatorcontrib><title>Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma</title><title>Allergy (Copenhagen)</title><addtitle>Allergy</addtitle><description>Background
Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR.
Methods
We investigated small airway function assessed by spirometry and impulse oscillometry, as well as Borg dyspnea scores at baseline and during a methacholine provocation test in 15 subjects with asymptomatic BHR, 15 asthma patients, and 15 healthy controls.
Results
At baseline, small airway function (R5–R20 and X5) was comparable between subjects with asymptomatic BHR and healthy controls, whereas asthma patients showed small airway dysfunction as reflected by higher R5–R20 and lower X5 values. During methacholine provocation, small airway dysfunction was more severe in asthma patients than in subjects with asymptomatic BHR. Interestingly, a higher increase in small airway dysfunction during methacholine provocation was associated with a higher increase in Borg dyspnea scores in subjects with asymptomatic BHR, but not in asthma patients.
Conclusion
Subjects with asymptomatic BHR may experience fewer symptoms in daily life because they have less small airway dysfunction.</description><subject>Adult</subject><subject>Airway management</subject><subject>Allergies</subject><subject>Asthma</subject><subject>Asthma - epidemiology</subject><subject>Asthma - immunology</subject><subject>Asthma - physiopathology</subject><subject>asymptomatic bronchial hyperresponsiveness</subject><subject>Asymptomatic Diseases - epidemiology</subject><subject>Body Mass Index</subject><subject>Bronchial Hyperreactivity - epidemiology</subject><subject>Bronchial Hyperreactivity - immunology</subject><subject>Bronchial Hyperreactivity - physiopathology</subject><subject>Cross-Sectional Studies</subject><subject>Female</subject><subject>Humans</subject><subject>Male</subject><subject>Methacholine Chloride - administration & dosage</subject><subject>Middle Aged</subject><subject>Pulmonary Disease, Chronic Obstructive - epidemiology</subject><subject>Randomized Controlled Trials as Topic - trends</subject><subject>Respiratory system</subject><subject>small airways</subject><subject>Young Adult</subject><issn>0105-4538</issn><issn>1398-9995</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0T1PxCAYwHFiNN75MvgFTBMXHarwAG0ZLxffkiYuurg0lEIO0zeh9dJvL-edDiYmsrD8-BN4EDoj-JqEdSPr-poAMNhDc0JFFgsh-D6aY4J5zDjNZujI-zeMcQoCH6IZMAIZZXSOXnPtfeSbkIikdWs5RdXkzdiqwXZtZNtI-qnph66Rg1VR6bpWrayso9XUa-e077vW2w_dbjLDSu6ODKtGnqADI2uvT3f7MXq5u31ePsT50_3jcpHHinGAuOK04lxmTFbGGM11SaBMmZGQ0KSqmCCaQmIMYVoA1VyBoZnIIBUqMaVQ9Bhdbru9695H7YeisV7pupat7kZfECZwmoW72D9owjhhLINAL37Rt250bXhIUClgwkGkQV1tlXKd906bone2kW4qCC42synCxxZfswn2fFccy0ZXP_J7GAHcbMHa1nr6u1Qs8nyb_AROWZjO</recordid><startdate>201311</startdate><enddate>201311</enddate><creator>Boudewijn, I. M.</creator><creator>Telenga, E. D.</creator><creator>Wiel, E.</creator><creator>Molen, T.</creator><creator>Schiphof, L.</creator><creator>ten Hacken, N. H. T.</creator><creator>Postma, D. S.</creator><creator>Berge, M.</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201311</creationdate><title>Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma</title><author>Boudewijn, I. M. ; Telenga, E. D. ; Wiel, E. ; Molen, T. ; Schiphof, L. ; ten Hacken, N. H. T. ; Postma, D. S. ; Berge, M.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4522-d53d55a84adfffe5eb12b74fa2636dd491e326ff14e923e5c2f3898279c6fb9c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Airway management</topic><topic>Allergies</topic><topic>Asthma</topic><topic>Asthma - epidemiology</topic><topic>Asthma - immunology</topic><topic>Asthma - physiopathology</topic><topic>asymptomatic bronchial hyperresponsiveness</topic><topic>Asymptomatic Diseases - epidemiology</topic><topic>Body Mass Index</topic><topic>Bronchial Hyperreactivity - epidemiology</topic><topic>Bronchial Hyperreactivity - immunology</topic><topic>Bronchial Hyperreactivity - physiopathology</topic><topic>Cross-Sectional Studies</topic><topic>Female</topic><topic>Humans</topic><topic>Male</topic><topic>Methacholine Chloride - administration & dosage</topic><topic>Middle Aged</topic><topic>Pulmonary Disease, Chronic Obstructive - epidemiology</topic><topic>Randomized Controlled Trials as Topic - trends</topic><topic>Respiratory system</topic><topic>small airways</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Boudewijn, I. M.</creatorcontrib><creatorcontrib>Telenga, E. D.</creatorcontrib><creatorcontrib>Wiel, E.</creatorcontrib><creatorcontrib>Molen, T.</creatorcontrib><creatorcontrib>Schiphof, L.</creatorcontrib><creatorcontrib>ten Hacken, N. H. T.</creatorcontrib><creatorcontrib>Postma, D. S.</creatorcontrib><creatorcontrib>Berge, M.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Allergy (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Boudewijn, I. M.</au><au>Telenga, E. D.</au><au>Wiel, E.</au><au>Molen, T.</au><au>Schiphof, L.</au><au>ten Hacken, N. H. T.</au><au>Postma, D. S.</au><au>Berge, M.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma</atitle><jtitle>Allergy (Copenhagen)</jtitle><addtitle>Allergy</addtitle><date>2013-11</date><risdate>2013</risdate><volume>68</volume><issue>11</issue><spage>1419</spage><epage>1426</epage><pages>1419-1426</pages><issn>0105-4538</issn><eissn>1398-9995</eissn><abstract>Background
Bronchial hyperresponsiveness (BHR) can be present in subjects without any respiratory symptoms. Little is known about the role of the small airways in asymptomatic subjects with BHR.
Methods
We investigated small airway function assessed by spirometry and impulse oscillometry, as well as Borg dyspnea scores at baseline and during a methacholine provocation test in 15 subjects with asymptomatic BHR, 15 asthma patients, and 15 healthy controls.
Results
At baseline, small airway function (R5–R20 and X5) was comparable between subjects with asymptomatic BHR and healthy controls, whereas asthma patients showed small airway dysfunction as reflected by higher R5–R20 and lower X5 values. During methacholine provocation, small airway dysfunction was more severe in asthma patients than in subjects with asymptomatic BHR. Interestingly, a higher increase in small airway dysfunction during methacholine provocation was associated with a higher increase in Borg dyspnea scores in subjects with asymptomatic BHR, but not in asthma patients.
Conclusion
Subjects with asymptomatic BHR may experience fewer symptoms in daily life because they have less small airway dysfunction.</abstract><cop>Denmark</cop><pub>Blackwell Publishing Ltd</pub><pmid>24128343</pmid><doi>10.1111/all.12242</doi><tpages>8</tpages></addata></record> |
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| ispartof | Allergy (Copenhagen), 2013-11, Vol.68 (11), p.1419-1426 |
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| source | MEDLINE; Access via Wiley Online Library; EZB-FREE-00999 freely available EZB journals; Wiley Online Library (Open Access Collection) |
| subjects | Adult Airway management Allergies Asthma Asthma - epidemiology Asthma - immunology Asthma - physiopathology asymptomatic bronchial hyperresponsiveness Asymptomatic Diseases - epidemiology Body Mass Index Bronchial Hyperreactivity - epidemiology Bronchial Hyperreactivity - immunology Bronchial Hyperreactivity - physiopathology Cross-Sectional Studies Female Humans Male Methacholine Chloride - administration & dosage Middle Aged Pulmonary Disease, Chronic Obstructive - epidemiology Randomized Controlled Trials as Topic - trends Respiratory system small airways Young Adult |
| title | Less small airway dysfunction in asymptomatic bronchial hyperresponsiveness than in asthma |
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