A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians
Abstract Introduction Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown. Materials and methods In this work we studied the association of rs6983267, rs10090154, and rs14472...
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| creator | Oskina, Natalia A Boyarskikh, Ulyana A., Ph.D Lazarev, Alexandr F Petrova, Valentina D., Ph.D Ganov, Dmitry I., Ph.D Tonacheva, Olga G., Ph.D Lifshits, Galina I., Ph.D Filipenko, Maxim L., Ph.D |
| description | Abstract Introduction Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown. Materials and methods In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8q24 SNPs were genotyped by real-time polymerase chain reaction in histologically confirmed CaP “cases” ( n = 392) and clinically evaluated “controls” ( n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression; differences were considered statistically significant if P |
| doi_str_mv | 10.1016/j.urolonc.2013.02.017 |
| format | Article |
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However, the risk conferred in men living in Russia is unknown. Materials and methods In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8q24 SNPs were genotyped by real-time polymerase chain reaction in histologically confirmed CaP “cases” ( n = 392) and clinically evaluated “controls” ( n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression; differences were considered statistically significant if P <0.05. Results We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37–2.81], P <0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41–3.26], P <0.0001) with CaP. The T-A rs10090154 to rs1447295 haplotype was also associated with CaP (OR [CI 95%] = 2.47 [1.59–3.85], P <0.0001). There was no significant association with the T allele of rs6983267: OR [CI 95%] = 0.9 [0.73–1.11], P > 0.05. Conclusion Thus, our investigation confirms the role of chromosomal region 8q24 in the development of CaP in the Russian population.</description><identifier>ISSN: 1078-1439</identifier><identifier>EISSN: 1873-2496</identifier><identifier>DOI: 10.1016/j.urolonc.2013.02.017</identifier><identifier>PMID: 23628314</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Adult ; Aged ; Alleles ; Biopsy ; Chromosomes, Human, Pair 8 ; Genetic Predisposition to Disease ; Genotype ; Humans ; Logistic Models ; Male ; Middle Aged ; Odds Ratio ; Polymorphism, Single Nucleotide ; Prostate cancer ; Prostatic Neoplasms - diagnosis ; Prostatic Neoplasms - genetics ; Real-Time Polymerase Chain Reaction ; Region of chromosome 8q24 ; Reproducibility of Results ; Risk Factors ; Russia ; Russian ; Single nucleotide polymorphisms (SNPs) ; Urology</subject><ispartof>Urologic oncology, 2014, Vol.32 (1), p.37.e7-37.e12</ispartof><rights>Elsevier Inc.</rights><rights>2014 Elsevier Inc.</rights><rights>Copyright © 2014 Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-f991d641953301f11a0c694e06829bfc57fa818025ac4651cfc9bb3678f0d31a3</citedby><cites>FETCH-LOGICAL-c420t-f991d641953301f11a0c694e06829bfc57fa818025ac4651cfc9bb3678f0d31a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1078143913001129$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,4010,27900,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23628314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Oskina, Natalia A</creatorcontrib><creatorcontrib>Boyarskikh, Ulyana A., Ph.D</creatorcontrib><creatorcontrib>Lazarev, Alexandr F</creatorcontrib><creatorcontrib>Petrova, Valentina D., Ph.D</creatorcontrib><creatorcontrib>Ganov, Dmitry I., Ph.D</creatorcontrib><creatorcontrib>Tonacheva, Olga G., Ph.D</creatorcontrib><creatorcontrib>Lifshits, Galina I., Ph.D</creatorcontrib><creatorcontrib>Filipenko, Maxim L., Ph.D</creatorcontrib><title>A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians</title><title>Urologic oncology</title><addtitle>Urol Oncol</addtitle><description>Abstract Introduction Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown. Materials and methods In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8q24 SNPs were genotyped by real-time polymerase chain reaction in histologically confirmed CaP “cases” ( n = 392) and clinically evaluated “controls” ( n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression; differences were considered statistically significant if P <0.05. Results We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37–2.81], P <0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41–3.26], P <0.0001) with CaP. The T-A rs10090154 to rs1447295 haplotype was also associated with CaP (OR [CI 95%] = 2.47 [1.59–3.85], P <0.0001). There was no significant association with the T allele of rs6983267: OR [CI 95%] = 0.9 [0.73–1.11], P > 0.05. Conclusion Thus, our investigation confirms the role of chromosomal region 8q24 in the development of CaP in the Russian population.</description><subject>Adult</subject><subject>Aged</subject><subject>Alleles</subject><subject>Biopsy</subject><subject>Chromosomes, Human, Pair 8</subject><subject>Genetic Predisposition to Disease</subject><subject>Genotype</subject><subject>Humans</subject><subject>Logistic Models</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Prostate cancer</subject><subject>Prostatic Neoplasms - diagnosis</subject><subject>Prostatic Neoplasms - genetics</subject><subject>Real-Time Polymerase Chain Reaction</subject><subject>Region of chromosome 8q24</subject><subject>Reproducibility of Results</subject><subject>Risk Factors</subject><subject>Russia</subject><subject>Russian</subject><subject>Single nucleotide polymorphisms (SNPs)</subject><subject>Urology</subject><issn>1078-1439</issn><issn>1873-2496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFUstu1TAQjRCIPuATQF6yaILHdhJ7A6oqKEiVWBTWluNMWl8SO7WTwv0k_hJH98KCDSuP5fMYz5mieAW0AgrN2121xjAGbytGgVeUVRTaJ8UpyJaXTKjmaa5pK0sQXJ0UZyntKAUhAZ4XJ4w3THIQp8WvSxJxHp01iwuepGXt9wR_msl55--ISSlYd3gLA4mpUZKzpr3IJVCqKNTighjfb3chWqZqYsM0bVKZPyLxqx0xLK5HModxP4U437s0JeI8kQ9MZPu7Tf2HW-7JHENazILEGm8xbphb12F0xqcXxbPBjAlfHs_z4tvHD1-vPpU3X64_X13elFYwupSDUtA3AlTNOYUBwFDbKIG0kUx1g63bwUiQlNXGiqYGO1jVdbxp5UB7DoafF28OurmZhxXToieXLI6j8RjWpEGoPFYupMrQ-gC1ue8UcdBzdJOJew1UbynpnT6mpLeUNGU6p5R5r48Wazdh_5f1J5YMeH8AYP7oo8Ook3WYR9K7iHbRfXD_tXj3j4Idc6TWjN9xj2kX1ujzFDXolAn6dluVbVOA5y0BpvhvjnS6Hg</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Oskina, Natalia A</creator><creator>Boyarskikh, Ulyana A., Ph.D</creator><creator>Lazarev, Alexandr F</creator><creator>Petrova, Valentina D., Ph.D</creator><creator>Ganov, Dmitry I., Ph.D</creator><creator>Tonacheva, Olga G., Ph.D</creator><creator>Lifshits, Galina I., Ph.D</creator><creator>Filipenko, Maxim L., Ph.D</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians</title><author>Oskina, Natalia A ; Boyarskikh, Ulyana A., Ph.D ; Lazarev, Alexandr F ; Petrova, Valentina D., Ph.D ; Ganov, Dmitry I., Ph.D ; Tonacheva, Olga G., Ph.D ; Lifshits, Galina I., Ph.D ; Filipenko, Maxim L., Ph.D</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-f991d641953301f11a0c694e06829bfc57fa818025ac4651cfc9bb3678f0d31a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Alleles</topic><topic>Biopsy</topic><topic>Chromosomes, Human, Pair 8</topic><topic>Genetic Predisposition to Disease</topic><topic>Genotype</topic><topic>Humans</topic><topic>Logistic Models</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Prostate cancer</topic><topic>Prostatic Neoplasms - diagnosis</topic><topic>Prostatic Neoplasms - genetics</topic><topic>Real-Time Polymerase Chain Reaction</topic><topic>Region of chromosome 8q24</topic><topic>Reproducibility of Results</topic><topic>Risk Factors</topic><topic>Russia</topic><topic>Russian</topic><topic>Single nucleotide polymorphisms (SNPs)</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Oskina, Natalia A</creatorcontrib><creatorcontrib>Boyarskikh, Ulyana A., Ph.D</creatorcontrib><creatorcontrib>Lazarev, Alexandr F</creatorcontrib><creatorcontrib>Petrova, Valentina D., Ph.D</creatorcontrib><creatorcontrib>Ganov, Dmitry I., Ph.D</creatorcontrib><creatorcontrib>Tonacheva, Olga G., Ph.D</creatorcontrib><creatorcontrib>Lifshits, Galina I., Ph.D</creatorcontrib><creatorcontrib>Filipenko, Maxim L., Ph.D</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oskina, Natalia A</au><au>Boyarskikh, Ulyana A., Ph.D</au><au>Lazarev, Alexandr F</au><au>Petrova, Valentina D., Ph.D</au><au>Ganov, Dmitry I., Ph.D</au><au>Tonacheva, Olga G., Ph.D</au><au>Lifshits, Galina I., Ph.D</au><au>Filipenko, Maxim L., Ph.D</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians</atitle><jtitle>Urologic oncology</jtitle><addtitle>Urol Oncol</addtitle><date>2014</date><risdate>2014</risdate><volume>32</volume><issue>1</issue><spage>37.e7</spage><epage>37.e12</epage><pages>37.e7-37.e12</pages><issn>1078-1439</issn><eissn>1873-2496</eissn><abstract>Abstract Introduction Multiple genetic studies have confirmed association of 8q24 variants with susceptibility to prostate cancer (CaP). However, the risk conferred in men living in Russia is unknown. Materials and methods In this work we studied the association of rs6983267, rs10090154, and rs1447295 single nucleotide polymorphisms (SNPs) with a risk of CaP development in men of Caucasoid descent living in the Siberian region of Russia. Three 8q24 SNPs were genotyped by real-time polymerase chain reaction in histologically confirmed CaP “cases” ( n = 392) and clinically evaluated “controls” ( n = 344). To evaluate the SNP effects on CaP susceptibility, odds ratio (OR) and confidence interval (CI) 95% were calculated. Allele and genotype frequencies in the groups were compared using logistic regression; differences were considered statistically significant if P <0.05. Results We showed statistically significant association of the A allele of rs1447295 (OR [CI 95%] = 1.96 [1.37–2.81], P <0.0001) and the T allele of rs10090154 (OR [CI 95%] = 2.14 [1.41–3.26], P <0.0001) with CaP. The T-A rs10090154 to rs1447295 haplotype was also associated with CaP (OR [CI 95%] = 2.47 [1.59–3.85], P <0.0001). There was no significant association with the T allele of rs6983267: OR [CI 95%] = 0.9 [0.73–1.11], P > 0.05. Conclusion Thus, our investigation confirms the role of chromosomal region 8q24 in the development of CaP in the Russian population.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>23628314</pmid><doi>10.1016/j.urolonc.2013.02.017</doi></addata></record> |
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| subjects | Adult Aged Alleles Biopsy Chromosomes, Human, Pair 8 Genetic Predisposition to Disease Genotype Humans Logistic Models Male Middle Aged Odds Ratio Polymorphism, Single Nucleotide Prostate cancer Prostatic Neoplasms - diagnosis Prostatic Neoplasms - genetics Real-Time Polymerase Chain Reaction Region of chromosome 8q24 Reproducibility of Results Risk Factors Russia Russian Single nucleotide polymorphisms (SNPs) Urology |
| title | A replication study examining association of rs6983267, rs10090154, and rs1447295 common single nucleotide polymorphisms in 8q24 region with prostate cancer in Siberians |
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