Gene-based urinary biomarkers for bladder cancer: An unfulfilled promise?
Abstract Objective Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytolo...
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| Veröffentlicht in: | Urologic oncology 2014, Vol.32 (1), p.48.e9-48.e17 |
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| creator | Sapre, Nikhil, M.B.Ch.B Anderson, Paul D., M.B.B.S., F.R.A.C.S Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon) Hovens, Christopher M., Ph.D Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S |
| description | Abstract Objective Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytology. Gene-based testing has shown great promise for biomarker profiling and this review addresses the current state of biomarker research in bladder cancer. Materials and methods A comprehensive review of all published literature on urinary biomarkers from 1970 - 2012 was conducted in PubMed. Keywords used alone or in combination were bladder cancer, diagnosis, surveillance, urinary biomarker, molecular biomarkers, methylation, gene expression, single nucleotide polymorphism and microRNA. The cited references of the manuscripts included in the review were also screened. Results We have reviewed various strategies currently used for gene-based biomarker profiling of bladder cancer. We have comprehensively summarized the performance of several biomarkers in the diagnosis and surveillance of bladder cancer. Finally we have identified biomarkers that have shown potential and now deserve the opportunity to be validated in the clinical setting. Conclusion Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer. |
| doi_str_mv | 10.1016/j.urolonc.2013.07.002 |
| format | Article |
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(Hon) ; Hovens, Christopher M., Ph.D ; Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</creator><creatorcontrib>Sapre, Nikhil, M.B.Ch.B ; Anderson, Paul D., M.B.B.S., F.R.A.C.S ; Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon) ; Hovens, Christopher M., Ph.D ; Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</creatorcontrib><description>Abstract Objective Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytology. Gene-based testing has shown great promise for biomarker profiling and this review addresses the current state of biomarker research in bladder cancer. Materials and methods A comprehensive review of all published literature on urinary biomarkers from 1970 - 2012 was conducted in PubMed. Keywords used alone or in combination were bladder cancer, diagnosis, surveillance, urinary biomarker, molecular biomarkers, methylation, gene expression, single nucleotide polymorphism and microRNA. The cited references of the manuscripts included in the review were also screened. Results We have reviewed various strategies currently used for gene-based biomarker profiling of bladder cancer. We have comprehensively summarized the performance of several biomarkers in the diagnosis and surveillance of bladder cancer. Finally we have identified biomarkers that have shown potential and now deserve the opportunity to be validated in the clinical setting. Conclusion Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer.</description><identifier>ISSN: 1078-1439</identifier><identifier>EISSN: 1873-2496</identifier><identifier>DOI: 10.1016/j.urolonc.2013.07.002</identifier><identifier>PMID: 24140246</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Biomarkers, Tumor - genetics ; Biomarkers, Tumor - urine ; Bladder cancer ; Cystoscopy ; DNA Methylation ; Humans ; microRNA ; MicroRNAs - genetics ; Microsatellite Repeats - genetics ; Molecular biomarkers ; Polymorphism, Single Nucleotide ; Recurrence ; Sensitivity and Specificity ; Urinary biomarker ; Urinary Bladder Neoplasms - diagnosis ; Urinary Bladder Neoplasms - genetics ; Urology</subject><ispartof>Urologic oncology, 2014, Vol.32 (1), p.48.e9-48.e17</ispartof><rights>2014</rights><rights>Crown Copyright © 2014. Published by Elsevier Inc. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c420t-a9a117d45163d89bfae621c70d8668e6db51e30a85de4a0a1aa83913b853c6e3</citedby><cites>FETCH-LOGICAL-c420t-a9a117d45163d89bfae621c70d8668e6db51e30a85de4a0a1aa83913b853c6e3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.urolonc.2013.07.002$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,780,784,3550,4024,27923,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24140246$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Sapre, Nikhil, M.B.Ch.B</creatorcontrib><creatorcontrib>Anderson, Paul D., M.B.B.S., F.R.A.C.S</creatorcontrib><creatorcontrib>Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon)</creatorcontrib><creatorcontrib>Hovens, Christopher M., Ph.D</creatorcontrib><creatorcontrib>Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</creatorcontrib><title>Gene-based urinary biomarkers for bladder cancer: An unfulfilled promise?</title><title>Urologic oncology</title><addtitle>Urol Oncol</addtitle><description>Abstract Objective Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytology. Gene-based testing has shown great promise for biomarker profiling and this review addresses the current state of biomarker research in bladder cancer. Materials and methods A comprehensive review of all published literature on urinary biomarkers from 1970 - 2012 was conducted in PubMed. Keywords used alone or in combination were bladder cancer, diagnosis, surveillance, urinary biomarker, molecular biomarkers, methylation, gene expression, single nucleotide polymorphism and microRNA. The cited references of the manuscripts included in the review were also screened. Results We have reviewed various strategies currently used for gene-based biomarker profiling of bladder cancer. We have comprehensively summarized the performance of several biomarkers in the diagnosis and surveillance of bladder cancer. Finally we have identified biomarkers that have shown potential and now deserve the opportunity to be validated in the clinical setting. Conclusion Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer.</description><subject>Biomarkers, Tumor - genetics</subject><subject>Biomarkers, Tumor - urine</subject><subject>Bladder cancer</subject><subject>Cystoscopy</subject><subject>DNA Methylation</subject><subject>Humans</subject><subject>microRNA</subject><subject>MicroRNAs - genetics</subject><subject>Microsatellite Repeats - genetics</subject><subject>Molecular biomarkers</subject><subject>Polymorphism, Single Nucleotide</subject><subject>Recurrence</subject><subject>Sensitivity and Specificity</subject><subject>Urinary biomarker</subject><subject>Urinary Bladder Neoplasms - diagnosis</subject><subject>Urinary Bladder Neoplasms - genetics</subject><subject>Urology</subject><issn>1078-1439</issn><issn>1873-2496</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkTtv3DAQhIkgRvxIfkIClWkkc0mKolzYMAy_AAMp4p6gyBXAM490yFOA-_fm4S4u0rjaLWZ2MN8S8h1oBxTk-apbcgop2o5R4B0dOkrZJ3ICauAtE6P8XHc6qBYEH4_JaSkrSkEogC_kmAkQlAl5Qh7vMWI7mYKuWbKPJm-byae1yS-YSzOn3EzBOIe5sSZazBfNdWyWOC9h9iFU12tOa1_w6is5mk0o-O0wz8jz3e3zzUP79Ov-8eb6qbWC0U1rRgMwONGD5E6N02xQMrADdUpKhdJNPSCnRvUOhaEGjFF8BD6pnluJ_Iz83J-tuX8WLBtd0y2GYCKmpWgQY23NhWJV2u-lNqdSMs76NfvabKuB6h1EvdIHiHoHUdNBV4jV9-MQsUxrdO-uf9Sq4GovwNrzr8esi_VY6Tif0W60S_7DiMv_Ltjgo7cmvOAWyyotOVaIGnRhmurfu0_uHgm8utXY8zfdZZo3</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Sapre, Nikhil, M.B.Ch.B</creator><creator>Anderson, Paul D., M.B.B.S., F.R.A.C.S</creator><creator>Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon)</creator><creator>Hovens, Christopher M., Ph.D</creator><creator>Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</creator><general>Elsevier Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Gene-based urinary biomarkers for bladder cancer: An unfulfilled promise?</title><author>Sapre, Nikhil, M.B.Ch.B ; Anderson, Paul D., M.B.B.S., F.R.A.C.S ; Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon) ; Hovens, Christopher M., Ph.D ; Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c420t-a9a117d45163d89bfae621c70d8668e6db51e30a85de4a0a1aa83913b853c6e3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Biomarkers, Tumor - genetics</topic><topic>Biomarkers, Tumor - urine</topic><topic>Bladder cancer</topic><topic>Cystoscopy</topic><topic>DNA Methylation</topic><topic>Humans</topic><topic>microRNA</topic><topic>MicroRNAs - genetics</topic><topic>Microsatellite Repeats - genetics</topic><topic>Molecular biomarkers</topic><topic>Polymorphism, Single Nucleotide</topic><topic>Recurrence</topic><topic>Sensitivity and Specificity</topic><topic>Urinary biomarker</topic><topic>Urinary Bladder Neoplasms - diagnosis</topic><topic>Urinary Bladder Neoplasms - genetics</topic><topic>Urology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Sapre, Nikhil, M.B.Ch.B</creatorcontrib><creatorcontrib>Anderson, Paul D., M.B.B.S., F.R.A.C.S</creatorcontrib><creatorcontrib>Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon)</creatorcontrib><creatorcontrib>Hovens, Christopher M., Ph.D</creatorcontrib><creatorcontrib>Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Urologic oncology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Sapre, Nikhil, M.B.Ch.B</au><au>Anderson, Paul D., M.B.B.S., F.R.A.C.S</au><au>Costello, Anthony J., M.B.B.S., M.D., F.R.A.C.S., F.R.C.S.I. (Hon)</au><au>Hovens, Christopher M., Ph.D</au><au>Corcoran, Niall M., M.B.B.Ch., B.A.O., Ph.D., F.R.A.C.S</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Gene-based urinary biomarkers for bladder cancer: An unfulfilled promise?</atitle><jtitle>Urologic oncology</jtitle><addtitle>Urol Oncol</addtitle><date>2014</date><risdate>2014</risdate><volume>32</volume><issue>1</issue><spage>48.e9</spage><epage>48.e17</epage><pages>48.e9-48.e17</pages><issn>1078-1439</issn><eissn>1873-2496</eissn><abstract>Abstract Objective Noninvasive biomarkers are used routinely in the clinical management of several cancers but bladder cancer detection and surveillance remains dependent on invasive procedures such as cystoscopy. No validated biomarker currently exists in routine clinical practice other than cytology. Gene-based testing has shown great promise for biomarker profiling and this review addresses the current state of biomarker research in bladder cancer. Materials and methods A comprehensive review of all published literature on urinary biomarkers from 1970 - 2012 was conducted in PubMed. Keywords used alone or in combination were bladder cancer, diagnosis, surveillance, urinary biomarker, molecular biomarkers, methylation, gene expression, single nucleotide polymorphism and microRNA. The cited references of the manuscripts included in the review were also screened. Results We have reviewed various strategies currently used for gene-based biomarker profiling of bladder cancer. We have comprehensively summarized the performance of several biomarkers in the diagnosis and surveillance of bladder cancer. Finally we have identified biomarkers that have shown potential and now deserve the opportunity to be validated in the clinical setting. Conclusion Several gene-based urinary biomarkers have demonstrated promise in initial studies, which now need to be rigorously validated in the clinical setting for them to be translated into clinically useful tests in diagnosis, surveillance or risk-stratification of bladder cancer.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>24140246</pmid><doi>10.1016/j.urolonc.2013.07.002</doi></addata></record> |
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| subjects | Biomarkers, Tumor - genetics Biomarkers, Tumor - urine Bladder cancer Cystoscopy DNA Methylation Humans microRNA MicroRNAs - genetics Microsatellite Repeats - genetics Molecular biomarkers Polymorphism, Single Nucleotide Recurrence Sensitivity and Specificity Urinary biomarker Urinary Bladder Neoplasms - diagnosis Urinary Bladder Neoplasms - genetics Urology |
| title | Gene-based urinary biomarkers for bladder cancer: An unfulfilled promise? |
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