Signal-peptide-mediated translocation is regulated by a p97-AIRAPL complex

Protein homoeostasis is a fundamental requirement for all living cells in order to survive in a dynamic surrounding. Proper levels of AIRAPL (arsenite-inducible RNA-associated protein-like protein) (ZFAND2B) are required in order to maintain cellular folding capacity in metazoans, and functional imp...

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Veröffentlicht in:	Biochemical journal 2014-01, Vol.457 (2), p.253-261
Hauptverfasser:	Glinka, Tal, Alter, Joel, Braunstein, Ilana, Tzach, Lolita, Wei Sheng, Chia, Geifman, Susana, Edelmann, Mariola J, Kessler, Benedikt M, Stanhill, Ariel
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptor Proteins, Signal Transducing Adenosine Triphosphatases - genetics Adenosine Triphosphatases - metabolism Animals Carrier Proteins - genetics Carrier Proteins - metabolism Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Cell Membrane - metabolism Endoplasmic Reticulum - metabolism Humans Mice Protein Binding - physiology Protein Sorting Signals - physiology Protein Transport - physiology RNA-Binding Proteins - genetics RNA-Binding Proteins - metabolism Valosin Containing Protein Zinc Fingers - physiology
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