Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques
Definition of antibody (Ab) functions capable of preventing mucosal HIV transmission may be critical to both effective vaccine development and the prophylactic use of monoclonal Abs. Although direct antibody-mediated neutralization is highly effective against cell-free virus, increasing evidence sug...
Gespeichert in:
| Veröffentlicht in: | Mucosal immunology 2014, Vol.7 (1), p.46-56 |
|---|---|
| Hauptverfasser: | , , , , , , , , , , , , , , |
| Format: | Artikel |
| Sprache: | eng |
| Schlagworte: | |
| Online-Zugang: | Volltext |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| container_end_page | 56 |
|---|---|
| container_issue | 1 |
| container_start_page | 46 |
| container_title | Mucosal immunology |
| container_volume | 7 |
| creator | Moog, C Dereuddre-Bosquet, N Teillaud, J-L Biedma, M E Holl, V Van Ham, G Heyndrickx, L Van Dorsselaer, A Katinger, D Vcelar, B Zolla-Pazner, S Mangeot, I Kelly, C Shattock, R J Le Grand, R |
| description | Definition of antibody (Ab) functions capable of preventing mucosal HIV transmission may be critical to both effective vaccine development and the prophylactic use of monoclonal Abs. Although direct antibody-mediated neutralization is highly effective against cell-free virus, increasing evidence suggests an important role for immunoglobulin G (IgG) Fcγ receptor (FcγR)–mediated inhibition of HIV replication. Thus, a panel of well-known neutralizing (NAbs) and nonneutralizing Abs (NoNAbs) were screened for their ability to block HIV acquisition and replication
in vitro
in either an independent or FcγR-dependent manner. Abs displaying the highest Fc-mediated inhibitory activity in various
in vitro
assays were selected, formulated for topical vaginal application in a microbicide gel, and tested for their antiviral activity against SHIVSF162P3 vaginal challenge in non-human primates (NHPs). A combination of three NAbs, 2G12, 2F5, and 4E10, fully prevented simian/human immunodeficiency virus (SHIV) vaginal transmission in 10 out of 15 treated NHPs, whereas a combination of two NoNAbs, 246-D and 4B3, although having no impact on SHIV acquisition, reduced plasma viral load. These results indicate that anti-HIV Abs with distinct neutralization and inhibitory functions differentially affect
in vivo
HIV acquisition and replication, by interfering with early viral replication and dissemination. Therefore, combining diverse Ab properties may potentiate the protective effects of anti-HIV-Ab-based strategies. |
| doi_str_mv | 10.1038/mi.2013.23 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1490779296</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>4030099081</sourcerecordid><originalsourceid>FETCH-LOGICAL-c453t-ffbad1034372fd9de7720f5f4553208542dfcb9ec84977bdb7ddf2f729d9b2f53</originalsourceid><addsrcrecordid>eNplkV1LHDEUhoMoftUbf0AJeFOU2eZjsplcFqm6IFjQ9nbI5GONzCTbJCPY_-B_NuOuYturHM558r6c8wJwjNEMI9p8HdyMIExnhG6BfSwoq2jN5tuvNa0QwWIPHKT0gNAcIUZ3wR6hTGCOm33w_COGbFR2jwYaa0sFg4WPcum87KFcrXqnZHbBT21vxhxl7_44v4TSa-iD_6vn_L3rXA7xqYyz64J2JkG5lM6n_K56e7X4BdW97Hvjl6Z8goNU8vdo0iewY2WfzNHmPQQ_L77fnV9V1zeXi_Nv15WqGc2VtZ3UZfWacmK10IZzgiyzNWOUoIbVRFvVCaOaWnDe6Y5rbYnlRGjREcvoIfiy1l3FMPnmdnBJmb6X3oQxtbgWiHNBxLygJ_-gD2GMZY1C8YYihkhDC3W6plQMKUVj21V0g4xPLUbtFFIxaKeQWjLBnzeSYzcY_Y6-pVKAszWQyqicKH7w_F_uBeGxngQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1783050283</pqid></control><display><type>article</type><title>Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques</title><source>MEDLINE</source><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>Alma/SFX Local Collection</source><creator>Moog, C ; Dereuddre-Bosquet, N ; Teillaud, J-L ; Biedma, M E ; Holl, V ; Van Ham, G ; Heyndrickx, L ; Van Dorsselaer, A ; Katinger, D ; Vcelar, B ; Zolla-Pazner, S ; Mangeot, I ; Kelly, C ; Shattock, R J ; Le Grand, R</creator><creatorcontrib>Moog, C ; Dereuddre-Bosquet, N ; Teillaud, J-L ; Biedma, M E ; Holl, V ; Van Ham, G ; Heyndrickx, L ; Van Dorsselaer, A ; Katinger, D ; Vcelar, B ; Zolla-Pazner, S ; Mangeot, I ; Kelly, C ; Shattock, R J ; Le Grand, R</creatorcontrib><description>Definition of antibody (Ab) functions capable of preventing mucosal HIV transmission may be critical to both effective vaccine development and the prophylactic use of monoclonal Abs. Although direct antibody-mediated neutralization is highly effective against cell-free virus, increasing evidence suggests an important role for immunoglobulin G (IgG) Fcγ receptor (FcγR)–mediated inhibition of HIV replication. Thus, a panel of well-known neutralizing (NAbs) and nonneutralizing Abs (NoNAbs) were screened for their ability to block HIV acquisition and replication
in vitro
in either an independent or FcγR-dependent manner. Abs displaying the highest Fc-mediated inhibitory activity in various
in vitro
assays were selected, formulated for topical vaginal application in a microbicide gel, and tested for their antiviral activity against SHIVSF162P3 vaginal challenge in non-human primates (NHPs). A combination of three NAbs, 2G12, 2F5, and 4E10, fully prevented simian/human immunodeficiency virus (SHIV) vaginal transmission in 10 out of 15 treated NHPs, whereas a combination of two NoNAbs, 246-D and 4B3, although having no impact on SHIV acquisition, reduced plasma viral load. These results indicate that anti-HIV Abs with distinct neutralization and inhibitory functions differentially affect
in vivo
HIV acquisition and replication, by interfering with early viral replication and dissemination. Therefore, combining diverse Ab properties may potentiate the protective effects of anti-HIV-Ab-based strategies.</description><identifier>ISSN: 1933-0219</identifier><identifier>EISSN: 1935-3456</identifier><identifier>DOI: 10.1038/mi.2013.23</identifier><identifier>PMID: 23591718</identifier><language>eng</language><publisher>New York: Nature Publishing Group US</publisher><subject>631/154/51/1568 ; 631/250/347 ; 692/699/255/1901 ; Allergology ; Animals ; Antibodies ; Antibodies, Monoclonal - administration & dosage ; Antibodies, Monoclonal - immunology ; Antibodies, Monoclonal - metabolism ; Antibodies, Neutralizing - administration & dosage ; Antibodies, Neutralizing - immunology ; Antibodies, Neutralizing - metabolism ; Antibody-Dependent Cell Cytotoxicity ; Biomedical and Life Sciences ; Biomedicine ; Female ; Gastroenterology ; HIV Antibodies - administration & dosage ; HIV Antibodies - immunology ; HIV Antibodies - metabolism ; Immunoglobulin Fc Fragments - immunology ; Immunoglobulin Fc Fragments - metabolism ; Immunology ; Macaca fascicularis ; Macrophages - immunology ; Macrophages - virology ; Neutralization Tests ; Protein Binding - immunology ; Receptors, IgG - metabolism ; Simian Acquired Immunodeficiency Syndrome - immunology ; Simian Acquired Immunodeficiency Syndrome - prevention & control ; Simian Acquired Immunodeficiency Syndrome - virology ; Simian Immunodeficiency Virus - immunology ; Vagina - immunology ; Vagina - virology ; Virus Replication - immunology</subject><ispartof>Mucosal immunology, 2014, Vol.7 (1), p.46-56</ispartof><rights>Society for Mucosal Immunology 2014</rights><rights>Copyright Nature Publishing Group Jan 2014</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c453t-ffbad1034372fd9de7720f5f4553208542dfcb9ec84977bdb7ddf2f729d9b2f53</citedby><cites>FETCH-LOGICAL-c453t-ffbad1034372fd9de7720f5f4553208542dfcb9ec84977bdb7ddf2f729d9b2f53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23591718$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moog, C</creatorcontrib><creatorcontrib>Dereuddre-Bosquet, N</creatorcontrib><creatorcontrib>Teillaud, J-L</creatorcontrib><creatorcontrib>Biedma, M E</creatorcontrib><creatorcontrib>Holl, V</creatorcontrib><creatorcontrib>Van Ham, G</creatorcontrib><creatorcontrib>Heyndrickx, L</creatorcontrib><creatorcontrib>Van Dorsselaer, A</creatorcontrib><creatorcontrib>Katinger, D</creatorcontrib><creatorcontrib>Vcelar, B</creatorcontrib><creatorcontrib>Zolla-Pazner, S</creatorcontrib><creatorcontrib>Mangeot, I</creatorcontrib><creatorcontrib>Kelly, C</creatorcontrib><creatorcontrib>Shattock, R J</creatorcontrib><creatorcontrib>Le Grand, R</creatorcontrib><title>Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques</title><title>Mucosal immunology</title><addtitle>Mucosal Immunol</addtitle><addtitle>Mucosal Immunol</addtitle><description>Definition of antibody (Ab) functions capable of preventing mucosal HIV transmission may be critical to both effective vaccine development and the prophylactic use of monoclonal Abs. Although direct antibody-mediated neutralization is highly effective against cell-free virus, increasing evidence suggests an important role for immunoglobulin G (IgG) Fcγ receptor (FcγR)–mediated inhibition of HIV replication. Thus, a panel of well-known neutralizing (NAbs) and nonneutralizing Abs (NoNAbs) were screened for their ability to block HIV acquisition and replication
in vitro
in either an independent or FcγR-dependent manner. Abs displaying the highest Fc-mediated inhibitory activity in various
in vitro
assays were selected, formulated for topical vaginal application in a microbicide gel, and tested for their antiviral activity against SHIVSF162P3 vaginal challenge in non-human primates (NHPs). A combination of three NAbs, 2G12, 2F5, and 4E10, fully prevented simian/human immunodeficiency virus (SHIV) vaginal transmission in 10 out of 15 treated NHPs, whereas a combination of two NoNAbs, 246-D and 4B3, although having no impact on SHIV acquisition, reduced plasma viral load. These results indicate that anti-HIV Abs with distinct neutralization and inhibitory functions differentially affect
in vivo
HIV acquisition and replication, by interfering with early viral replication and dissemination. Therefore, combining diverse Ab properties may potentiate the protective effects of anti-HIV-Ab-based strategies.</description><subject>631/154/51/1568</subject><subject>631/250/347</subject><subject>692/699/255/1901</subject><subject>Allergology</subject><subject>Animals</subject><subject>Antibodies</subject><subject>Antibodies, Monoclonal - administration & dosage</subject><subject>Antibodies, Monoclonal - immunology</subject><subject>Antibodies, Monoclonal - metabolism</subject><subject>Antibodies, Neutralizing - administration & dosage</subject><subject>Antibodies, Neutralizing - immunology</subject><subject>Antibodies, Neutralizing - metabolism</subject><subject>Antibody-Dependent Cell Cytotoxicity</subject><subject>Biomedical and Life Sciences</subject><subject>Biomedicine</subject><subject>Female</subject><subject>Gastroenterology</subject><subject>HIV Antibodies - administration & dosage</subject><subject>HIV Antibodies - immunology</subject><subject>HIV Antibodies - metabolism</subject><subject>Immunoglobulin Fc Fragments - immunology</subject><subject>Immunoglobulin Fc Fragments - metabolism</subject><subject>Immunology</subject><subject>Macaca fascicularis</subject><subject>Macrophages - immunology</subject><subject>Macrophages - virology</subject><subject>Neutralization Tests</subject><subject>Protein Binding - immunology</subject><subject>Receptors, IgG - metabolism</subject><subject>Simian Acquired Immunodeficiency Syndrome - immunology</subject><subject>Simian Acquired Immunodeficiency Syndrome - prevention & control</subject><subject>Simian Acquired Immunodeficiency Syndrome - virology</subject><subject>Simian Immunodeficiency Virus - immunology</subject><subject>Vagina - immunology</subject><subject>Vagina - virology</subject><subject>Virus Replication - immunology</subject><issn>1933-0219</issn><issn>1935-3456</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNplkV1LHDEUhoMoftUbf0AJeFOU2eZjsplcFqm6IFjQ9nbI5GONzCTbJCPY_-B_NuOuYturHM558r6c8wJwjNEMI9p8HdyMIExnhG6BfSwoq2jN5tuvNa0QwWIPHKT0gNAcIUZ3wR6hTGCOm33w_COGbFR2jwYaa0sFg4WPcum87KFcrXqnZHbBT21vxhxl7_44v4TSa-iD_6vn_L3rXA7xqYyz64J2JkG5lM6n_K56e7X4BdW97Hvjl6Z8goNU8vdo0iewY2WfzNHmPQQ_L77fnV9V1zeXi_Nv15WqGc2VtZ3UZfWacmK10IZzgiyzNWOUoIbVRFvVCaOaWnDe6Y5rbYnlRGjREcvoIfiy1l3FMPnmdnBJmb6X3oQxtbgWiHNBxLygJ_-gD2GMZY1C8YYihkhDC3W6plQMKUVj21V0g4xPLUbtFFIxaKeQWjLBnzeSYzcY_Y6-pVKAszWQyqicKH7w_F_uBeGxngQ</recordid><startdate>2014</startdate><enddate>2014</enddate><creator>Moog, C</creator><creator>Dereuddre-Bosquet, N</creator><creator>Teillaud, J-L</creator><creator>Biedma, M E</creator><creator>Holl, V</creator><creator>Van Ham, G</creator><creator>Heyndrickx, L</creator><creator>Van Dorsselaer, A</creator><creator>Katinger, D</creator><creator>Vcelar, B</creator><creator>Zolla-Pazner, S</creator><creator>Mangeot, I</creator><creator>Kelly, C</creator><creator>Shattock, R J</creator><creator>Le Grand, R</creator><general>Nature Publishing Group US</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>H94</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>2014</creationdate><title>Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques</title><author>Moog, C ; Dereuddre-Bosquet, N ; Teillaud, J-L ; Biedma, M E ; Holl, V ; Van Ham, G ; Heyndrickx, L ; Van Dorsselaer, A ; Katinger, D ; Vcelar, B ; Zolla-Pazner, S ; Mangeot, I ; Kelly, C ; Shattock, R J ; Le Grand, R</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c453t-ffbad1034372fd9de7720f5f4553208542dfcb9ec84977bdb7ddf2f729d9b2f53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>631/154/51/1568</topic><topic>631/250/347</topic><topic>692/699/255/1901</topic><topic>Allergology</topic><topic>Animals</topic><topic>Antibodies</topic><topic>Antibodies, Monoclonal - administration & dosage</topic><topic>Antibodies, Monoclonal - immunology</topic><topic>Antibodies, Monoclonal - metabolism</topic><topic>Antibodies, Neutralizing - administration & dosage</topic><topic>Antibodies, Neutralizing - immunology</topic><topic>Antibodies, Neutralizing - metabolism</topic><topic>Antibody-Dependent Cell Cytotoxicity</topic><topic>Biomedical and Life Sciences</topic><topic>Biomedicine</topic><topic>Female</topic><topic>Gastroenterology</topic><topic>HIV Antibodies - administration & dosage</topic><topic>HIV Antibodies - immunology</topic><topic>HIV Antibodies - metabolism</topic><topic>Immunoglobulin Fc Fragments - immunology</topic><topic>Immunoglobulin Fc Fragments - metabolism</topic><topic>Immunology</topic><topic>Macaca fascicularis</topic><topic>Macrophages - immunology</topic><topic>Macrophages - virology</topic><topic>Neutralization Tests</topic><topic>Protein Binding - immunology</topic><topic>Receptors, IgG - metabolism</topic><topic>Simian Acquired Immunodeficiency Syndrome - immunology</topic><topic>Simian Acquired Immunodeficiency Syndrome - prevention & control</topic><topic>Simian Acquired Immunodeficiency Syndrome - virology</topic><topic>Simian Immunodeficiency Virus - immunology</topic><topic>Vagina - immunology</topic><topic>Vagina - virology</topic><topic>Virus Replication - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moog, C</creatorcontrib><creatorcontrib>Dereuddre-Bosquet, N</creatorcontrib><creatorcontrib>Teillaud, J-L</creatorcontrib><creatorcontrib>Biedma, M E</creatorcontrib><creatorcontrib>Holl, V</creatorcontrib><creatorcontrib>Van Ham, G</creatorcontrib><creatorcontrib>Heyndrickx, L</creatorcontrib><creatorcontrib>Van Dorsselaer, A</creatorcontrib><creatorcontrib>Katinger, D</creatorcontrib><creatorcontrib>Vcelar, B</creatorcontrib><creatorcontrib>Zolla-Pazner, S</creatorcontrib><creatorcontrib>Mangeot, I</creatorcontrib><creatorcontrib>Kelly, C</creatorcontrib><creatorcontrib>Shattock, R J</creatorcontrib><creatorcontrib>Le Grand, R</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Mucosal immunology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moog, C</au><au>Dereuddre-Bosquet, N</au><au>Teillaud, J-L</au><au>Biedma, M E</au><au>Holl, V</au><au>Van Ham, G</au><au>Heyndrickx, L</au><au>Van Dorsselaer, A</au><au>Katinger, D</au><au>Vcelar, B</au><au>Zolla-Pazner, S</au><au>Mangeot, I</au><au>Kelly, C</au><au>Shattock, R J</au><au>Le Grand, R</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques</atitle><jtitle>Mucosal immunology</jtitle><stitle>Mucosal Immunol</stitle><addtitle>Mucosal Immunol</addtitle><date>2014</date><risdate>2014</risdate><volume>7</volume><issue>1</issue><spage>46</spage><epage>56</epage><pages>46-56</pages><issn>1933-0219</issn><eissn>1935-3456</eissn><abstract>Definition of antibody (Ab) functions capable of preventing mucosal HIV transmission may be critical to both effective vaccine development and the prophylactic use of monoclonal Abs. Although direct antibody-mediated neutralization is highly effective against cell-free virus, increasing evidence suggests an important role for immunoglobulin G (IgG) Fcγ receptor (FcγR)–mediated inhibition of HIV replication. Thus, a panel of well-known neutralizing (NAbs) and nonneutralizing Abs (NoNAbs) were screened for their ability to block HIV acquisition and replication
in vitro
in either an independent or FcγR-dependent manner. Abs displaying the highest Fc-mediated inhibitory activity in various
in vitro
assays were selected, formulated for topical vaginal application in a microbicide gel, and tested for their antiviral activity against SHIVSF162P3 vaginal challenge in non-human primates (NHPs). A combination of three NAbs, 2G12, 2F5, and 4E10, fully prevented simian/human immunodeficiency virus (SHIV) vaginal transmission in 10 out of 15 treated NHPs, whereas a combination of two NoNAbs, 246-D and 4B3, although having no impact on SHIV acquisition, reduced plasma viral load. These results indicate that anti-HIV Abs with distinct neutralization and inhibitory functions differentially affect
in vivo
HIV acquisition and replication, by interfering with early viral replication and dissemination. Therefore, combining diverse Ab properties may potentiate the protective effects of anti-HIV-Ab-based strategies.</abstract><cop>New York</cop><pub>Nature Publishing Group US</pub><pmid>23591718</pmid><doi>10.1038/mi.2013.23</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1933-0219 |
| ispartof | Mucosal immunology, 2014, Vol.7 (1), p.46-56 |
| issn | 1933-0219 1935-3456 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1490779296 |
| source | MEDLINE; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; Alma/SFX Local Collection |
| subjects | 631/154/51/1568 631/250/347 692/699/255/1901 Allergology Animals Antibodies Antibodies, Monoclonal - administration & dosage Antibodies, Monoclonal - immunology Antibodies, Monoclonal - metabolism Antibodies, Neutralizing - administration & dosage Antibodies, Neutralizing - immunology Antibodies, Neutralizing - metabolism Antibody-Dependent Cell Cytotoxicity Biomedical and Life Sciences Biomedicine Female Gastroenterology HIV Antibodies - administration & dosage HIV Antibodies - immunology HIV Antibodies - metabolism Immunoglobulin Fc Fragments - immunology Immunoglobulin Fc Fragments - metabolism Immunology Macaca fascicularis Macrophages - immunology Macrophages - virology Neutralization Tests Protein Binding - immunology Receptors, IgG - metabolism Simian Acquired Immunodeficiency Syndrome - immunology Simian Acquired Immunodeficiency Syndrome - prevention & control Simian Acquired Immunodeficiency Syndrome - virology Simian Immunodeficiency Virus - immunology Vagina - immunology Vagina - virology Virus Replication - immunology |
| title | Protective effect of vaginal application of neutralizing and nonneutralizing inhibitory antibodies against vaginal SHIV challenge in macaques |
| url | https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-02-13T03%3A21%3A30IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Protective%20effect%20of%20vaginal%20application%20of%20neutralizing%20and%20nonneutralizing%20inhibitory%20antibodies%20against%20vaginal%20SHIV%20challenge%20in%20macaques&rft.jtitle=Mucosal%20immunology&rft.au=Moog,%20C&rft.date=2014&rft.volume=7&rft.issue=1&rft.spage=46&rft.epage=56&rft.pages=46-56&rft.issn=1933-0219&rft.eissn=1935-3456&rft_id=info:doi/10.1038/mi.2013.23&rft_dat=%3Cproquest_cross%3E4030099081%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1783050283&rft_id=info:pmid/23591718&rfr_iscdi=true |