Activating transcription factor 4 links metabolic stress to interleukin-6 expression in macrophages

Chronic inflammation is a molecular element of the metabolic syndrome and type 2 diabetes. Saturated fatty acids (SFAs) are considered to be an important proinflammatory factor. However, it is still incompletely understood how SFAs induce proinflammatory cytokine expression. Hereby we report that ac...

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Veröffentlicht in:	Diabetes (New York, N.Y.) N.Y.), 2014-01, Vol.63 (1), p.152-161
Hauptverfasser:	Iwasaki, Yorihiro, Suganami, Takayoshi, Hachiya, Rumi, Shirakawa, Ibuki, Kim-Saijo, Misa, Tanaka, Miyako, Hamaguchi, Miho, Takai-Igarashi, Takako, Nakai, Michikazu, Miyamoto, Yoshihiro, Ogawa, Yoshihiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating Transcription Factor 4 - genetics Activating Transcription Factor 4 - metabolism Animals Cytokines Deoxyribonucleic acid Diabetes DNA eIF-2 Kinase - genetics eIF-2 Kinase - metabolism Fatty acids Fatty Acids - metabolism Haploinsufficiency Health aspects Identification and classification Immune system Inflammation - genetics Inflammation - metabolism Interleukin-6 Interleukin-6 - genetics Interleukin-6 - metabolism Macrophages - metabolism Metabolic syndrome Mice Mice, Knockout NF-kappa B - metabolism Promoter Regions, Genetic Properties Ribonucleic acid RNA Signal Transduction - physiology Stress, Physiological - physiology Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Transcription factors
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