Cu(I)–NHC Catalyzed Asymmetric Silyl Transfer to Unsaturated Lactams and Amides

The first asymmetric silylation of unsaturated lactams and amides using Cu(I)–NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.

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Veröffentlicht in:	Organic letters 2014-01, Vol.16 (2), p.476-479
Hauptverfasser:	Pace, Vittorio, Rae, James P, Procter, David J
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Sprache:	eng
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description	The first asymmetric silylation of unsaturated lactams and amides using Cu(I)–NHC catalysts and PhMe2SiBpin has been accomplished. The method has been exploited in an expedient asymmetric synthesis of the (R)-enantiomer of the nootropic drug oxiracetam.
doi_str_mv	10.1021/ol4033623
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source	ACS Journals: American Chemical Society Web Editions
title	Cu(I)–NHC Catalyzed Asymmetric Silyl Transfer to Unsaturated Lactams and Amides
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