Effect and Reporting Bias of RhoA/ROCK-Blockade Intervention on Locomotor Recovery After Spinal Cord Injury: A Systematic Review and Meta-analysis

IMPORTANCE Blockade of small GTPase-RhoA signaling pathway is considered a candidate translational strategy to improve functional outcome after spinal cord injury (SCI) in humans. Pooling preclinical evidence by orthodox meta-analysis is confounded by missing data (publication bias). OBJECTIVE To co...

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Veröffentlicht in:	JAMA neurology 2014-01, Vol.71 (1), p.91-99
Hauptverfasser:	Watzlawick, Ralf, Sena, Emily S, Dirnagl, Ulrich, Brommer, Benedikt, Kopp, Marcel A, Macleod, Malcolm R, Howells, David W, Schwab, Jan M
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Disease Models, Animal Evidence-Based Medicine - trends Humans Locomotion - physiology Nerve Regeneration - physiology Neural Pathways - physiology rho-Associated Kinases - antagonists & inhibitors rho-Associated Kinases - therapeutic use Spinal Cord Injuries - drug therapy Spinal Cord Injuries - metabolism Spinal Cord Injuries - physiopathology
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