Do Repeated Skin Barrier Measurements Influence Each Other's Results? An Explorative Study
Background: Biophysical skin measurement techniques are widely used to quantify the skin barrier function. In clinical research usually several parameters are subsequently measured in the same skin areas. In this study, possible interfering effects of subsequent measurement procedures on transepider...
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| Veröffentlicht in: | Skin pharmacology and physiology 2014-01, Vol.27 (2), p.90-96 |
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| creator | Kottner, Jan Ludriksone, Laine Garcia Bartels, Natalie Blume-Peytavi, Ulrike |
| description | Background: Biophysical skin measurement techniques are widely used to quantify the skin barrier function. In clinical research usually several parameters are subsequently measured in the same skin areas. In this study, possible interfering effects of subsequent measurement procedures on transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin surface pH were investigated. Methods: An exploratory study was conducted. Twelve young (mean age 32.9 ± 7.2 years) and 12 elderly (mean age 68.3 ± 2.5 years) subjects without any skin diseases were enrolled. The parameters TEWL, skin surface pH, SCH, sebum content, and surface evaluation of living skin were obtained successively in pairs from 4 contralateral volar forearm skin areas. Results: SCH and skin surface pH seemed to be unaffected by previous measurement procedures. TEWL was systematically increased after pH and systematically decreased after stratum corneum measurements. Conclusions: Measurements per se might interact with the skin, thus changing its characteristics. If several skin barrier function parameters need to be assessed subsequently in the same skin areas, we recommend that TEWL should be measured first followed by all others. |
| doi_str_mv | 10.1159/000351882 |
| format | Article |
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An Explorative Study</title><source>Karger Journals</source><source>MEDLINE</source><source>Alma/SFX Local Collection</source><creator>Kottner, Jan ; Ludriksone, Laine ; Garcia Bartels, Natalie ; Blume-Peytavi, Ulrike</creator><creatorcontrib>Kottner, Jan ; Ludriksone, Laine ; Garcia Bartels, Natalie ; Blume-Peytavi, Ulrike</creatorcontrib><description>Background: Biophysical skin measurement techniques are widely used to quantify the skin barrier function. In clinical research usually several parameters are subsequently measured in the same skin areas. In this study, possible interfering effects of subsequent measurement procedures on transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin surface pH were investigated. Methods: An exploratory study was conducted. Twelve young (mean age 32.9 ± 7.2 years) and 12 elderly (mean age 68.3 ± 2.5 years) subjects without any skin diseases were enrolled. The parameters TEWL, skin surface pH, SCH, sebum content, and surface evaluation of living skin were obtained successively in pairs from 4 contralateral volar forearm skin areas. Results: SCH and skin surface pH seemed to be unaffected by previous measurement procedures. TEWL was systematically increased after pH and systematically decreased after stratum corneum measurements. Conclusions: Measurements per se might interact with the skin, thus changing its characteristics. If several skin barrier function parameters need to be assessed subsequently in the same skin areas, we recommend that TEWL should be measured first followed by all others.</description><identifier>ISSN: 1660-5527</identifier><identifier>EISSN: 1660-5535</identifier><identifier>DOI: 10.1159/000351882</identifier><identifier>PMID: 24157535</identifier><language>eng</language><publisher>Basel, Switzerland: S. Karger AG</publisher><subject>Adult ; Aged ; Aging - physiology ; Clinical Laboratory Techniques - methods ; Female ; Humans ; Hydrogen-Ion Concentration ; Male ; Original Paper ; Sebum - metabolism ; Skin - metabolism ; Skin Physiological Phenomena ; Surface Properties ; Water - metabolism ; Young Adult</subject><ispartof>Skin pharmacology and physiology, 2014-01, Vol.27 (2), p.90-96</ispartof><rights>2013 S. Karger AG, Basel</rights><rights>Copyright (c) 2014 S. Karger AG, Basel</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c334t-1c1030c50d8f6f22830866fc63b7a04584b926de81454f2e3d9f7822f778518a3</citedby><cites>FETCH-LOGICAL-c334t-1c1030c50d8f6f22830866fc63b7a04584b926de81454f2e3d9f7822f778518a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,2423,4010,27902,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24157535$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kottner, Jan</creatorcontrib><creatorcontrib>Ludriksone, Laine</creatorcontrib><creatorcontrib>Garcia Bartels, Natalie</creatorcontrib><creatorcontrib>Blume-Peytavi, Ulrike</creatorcontrib><title>Do Repeated Skin Barrier Measurements Influence Each Other's Results? An Explorative Study</title><title>Skin pharmacology and physiology</title><addtitle>Skin Pharmacol Physiol</addtitle><description>Background: Biophysical skin measurement techniques are widely used to quantify the skin barrier function. In clinical research usually several parameters are subsequently measured in the same skin areas. In this study, possible interfering effects of subsequent measurement procedures on transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin surface pH were investigated. Methods: An exploratory study was conducted. Twelve young (mean age 32.9 ± 7.2 years) and 12 elderly (mean age 68.3 ± 2.5 years) subjects without any skin diseases were enrolled. The parameters TEWL, skin surface pH, SCH, sebum content, and surface evaluation of living skin were obtained successively in pairs from 4 contralateral volar forearm skin areas. Results: SCH and skin surface pH seemed to be unaffected by previous measurement procedures. TEWL was systematically increased after pH and systematically decreased after stratum corneum measurements. Conclusions: Measurements per se might interact with the skin, thus changing its characteristics. If several skin barrier function parameters need to be assessed subsequently in the same skin areas, we recommend that TEWL should be measured first followed by all others.</description><subject>Adult</subject><subject>Aged</subject><subject>Aging - physiology</subject><subject>Clinical Laboratory Techniques - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Hydrogen-Ion Concentration</subject><subject>Male</subject><subject>Original Paper</subject><subject>Sebum - metabolism</subject><subject>Skin - metabolism</subject><subject>Skin Physiological Phenomena</subject><subject>Surface Properties</subject><subject>Water - metabolism</subject><subject>Young Adult</subject><issn>1660-5527</issn><issn>1660-5535</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNpd0DtPAkEQB_CN0Qiihb0xm1ioBbqP2weVQUQlwZCINjaX5W5WDu6Bu3dGvr1HwCssNrPFbyYzf4ROKbmhVPRuCSFcUK3ZHmpTKUlXCC72mz9TLXTk_YIQJhWVh6jFAipUbdro46HAr7ACU0KMp8skx_fGuQQcfgHjKwcZ5KXHo9ymFeQR4KGJ5nhSzsFd-rrTV2np73A_x8OfVVo4UybfgKdlFa-P0YE1qYeTXe2g98fh2-C5O548jQb9cTfiPCi7NKKEk0iQWFtpGdOcaCltJPlMGRIIHcx6TMagaSACy4DHPas0Y1YpXR9teAddbeeuXPFVgS_DLPERpKnJoah8SIMeUSogjNX04h9dFJXL6-1CKiiTpH4bdb1VkSu8d2DDlUsy49YhJeEm8LAJvLbnu4nVLIO4kX8J1-BsC5bGfYJrwK7_F3_FgMw</recordid><startdate>201401</startdate><enddate>201401</enddate><creator>Kottner, Jan</creator><creator>Ludriksone, Laine</creator><creator>Garcia Bartels, Natalie</creator><creator>Blume-Peytavi, Ulrike</creator><general>S. 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An Explorative Study</title><author>Kottner, Jan ; Ludriksone, Laine ; Garcia Bartels, Natalie ; Blume-Peytavi, Ulrike</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c334t-1c1030c50d8f6f22830866fc63b7a04584b926de81454f2e3d9f7822f778518a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aging - physiology</topic><topic>Clinical Laboratory Techniques - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Hydrogen-Ion Concentration</topic><topic>Male</topic><topic>Original Paper</topic><topic>Sebum - metabolism</topic><topic>Skin - metabolism</topic><topic>Skin Physiological Phenomena</topic><topic>Surface Properties</topic><topic>Water - metabolism</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kottner, Jan</creatorcontrib><creatorcontrib>Ludriksone, Laine</creatorcontrib><creatorcontrib>Garcia Bartels, Natalie</creatorcontrib><creatorcontrib>Blume-Peytavi, Ulrike</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>Environmental Sciences and Pollution Management</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Skin pharmacology and physiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kottner, Jan</au><au>Ludriksone, Laine</au><au>Garcia Bartels, Natalie</au><au>Blume-Peytavi, Ulrike</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Do Repeated Skin Barrier Measurements Influence Each Other's Results? An Explorative Study</atitle><jtitle>Skin pharmacology and physiology</jtitle><addtitle>Skin Pharmacol Physiol</addtitle><date>2014-01</date><risdate>2014</risdate><volume>27</volume><issue>2</issue><spage>90</spage><epage>96</epage><pages>90-96</pages><issn>1660-5527</issn><eissn>1660-5535</eissn><abstract>Background: Biophysical skin measurement techniques are widely used to quantify the skin barrier function. In clinical research usually several parameters are subsequently measured in the same skin areas. In this study, possible interfering effects of subsequent measurement procedures on transepidermal water loss (TEWL), stratum corneum hydration (SCH) and skin surface pH were investigated. Methods: An exploratory study was conducted. Twelve young (mean age 32.9 ± 7.2 years) and 12 elderly (mean age 68.3 ± 2.5 years) subjects without any skin diseases were enrolled. The parameters TEWL, skin surface pH, SCH, sebum content, and surface evaluation of living skin were obtained successively in pairs from 4 contralateral volar forearm skin areas. Results: SCH and skin surface pH seemed to be unaffected by previous measurement procedures. TEWL was systematically increased after pH and systematically decreased after stratum corneum measurements. Conclusions: Measurements per se might interact with the skin, thus changing its characteristics. If several skin barrier function parameters need to be assessed subsequently in the same skin areas, we recommend that TEWL should be measured first followed by all others.</abstract><cop>Basel, Switzerland</cop><pub>S. Karger AG</pub><pmid>24157535</pmid><doi>10.1159/000351882</doi><tpages>7</tpages></addata></record> |
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| subjects | Adult Aged Aging - physiology Clinical Laboratory Techniques - methods Female Humans Hydrogen-Ion Concentration Male Original Paper Sebum - metabolism Skin - metabolism Skin Physiological Phenomena Surface Properties Water - metabolism Young Adult |
| title | Do Repeated Skin Barrier Measurements Influence Each Other's Results? An Explorative Study |
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