Pharmacokinetics of an injectable long-acting parenteral formulation of doxycycline hyclate in pigs

Based on its ideal PK/PD ratios, doxycycline hyclate (DOX‐h), a time‐dependant antibacterial, is ideally expected to achieve sustained plasma drug concentrations at or slightly above the MIC level for as long as possible between dosing intervals. Pursuing this end, a poloxamer‐based matrix was used...

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Veröffentlicht in:	Journal of veterinary pharmacology and therapeutics 2014-02, Vol.37 (1), p.83-89
Hauptverfasser:	Gutiérrez, L., Ocampo, L., Espinosa, F., Sumano, H.
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Anti-Bacterial Agents - administration & dosage Anti-Bacterial Agents - pharmacokinetics Area Under Curve Biological Availability Delayed-Action Preparations Doxycycline - administration & dosage Doxycycline - pharmacokinetics Half-Life Injections, Subcutaneous Microbial Sensitivity Tests Swine - metabolism
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