Differences in RRM1 protein expression between diagnostic biopsies and resection specimens, and changes during carboplatin and paclitaxel treatment, in non-small-cell lung cancer

Aims It is of interest whether expression of potentially predictive biomarkers changes during chemotherapy, for accurate evaluation after first‐line chemotherapy. This study aimed to evaluate changes in RRM1 expression during chemotherapy. Materials and methods RRM1 immunohistochemistry was performe...

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Veröffentlicht in:	Histopathology 2014-02, Vol.64 (3), p.412-420
Hauptverfasser:	Jakobsen, Jan N, Santoni-Rugiu, Eric, Sørensen, Jens B
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Antineoplastic Combined Chemotherapy Protocols - therapeutic use biomarker Biopsy Carboplatin - administration & dosage Carcinoma, Non-Small-Cell Lung - drug therapy Carcinoma, Non-Small-Cell Lung - metabolism Carcinoma, Non-Small-Cell Lung - pathology chemotherapy Female Humans Immunohistochemistry Lung Neoplasms - drug therapy Lung Neoplasms - metabolism Lung Neoplasms - pathology Lymphatic Metastasis Male Middle Aged Neoadjuvant Therapy non-small-cell lung cancer Paclitaxel - administration & dosage RRM1 Treatment Outcome Tumor Suppressor Proteins - metabolism
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