Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice

Aldehyde reductase (AKR1A), a member of the aldo-keto reductase superfamily, is highly expressed in the liver and is involved in both the detoxification of carbonyl compounds and ascorbic acid biosynthesis. By comparison with wild-type mice, Akr1a-knockout (Akr1a−/−) mice and human Akrla-transgenic...

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Veröffentlicht in:	Life sciences (1973) 2014-01, Vol.95 (1), p.1-8
Hauptverfasser:	Ito, Junitsu, Otsuki, Noriyuki, Zhang, Xuhong, Konno, Tasuku, Kurahashi, Toshihiro, Takahashi, Motoko, Yamato, Mayumi, Matsuoka, Yuta, Yamada, Ken-ichi, Miyata, Satoshi, Fujii, Junichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Adjuvants, Anesthesia - pharmacology Aldehyde reductase Aldehyde Reductase - genetics Anesthesia Animals Ascorbic acid Ascorbic Acid - pharmacology Ascorbic Acid Deficiency - complications Female Humans Liver - metabolism Male Mice Mice, Inbred C57BL Mice, Knockout Mice, Transgenic Pentobarbital Pentobarbital - pharmacology Rats Reflex, Righting - drug effects Time Factors
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