miR-218 opposes a critical RTK-HIF pathway in mesenchymal glioblastoma

Glioblastoma multiforme (GBM) and the mesenchymal GBM subtype in particular are highly malignant tumors that frequently exhibit regions of severe hypoxia and necrosis. Because these features correlate with poor prognosis, we investigated microRNAs whose expression might regulate hypoxic GBM cell sur...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS 2014-01, Vol.111 (1), p.291-296
Hauptverfasser:	Mathew, Lijoy K., Skuli, Nicolas, Mucaj, Vera, Lee, Samuel S., Zinn, Pascal O., Sathyan, Pratheesh, Imtiyaz, Hongxia Z., Zhang, Zhongfa, Davuluri, Ramana V., Rao, Shilpa, Venneti, Sriram, Lal, Priti, Lathia, Justin D., Rich, Jeremy N., Keith, Brian, Minn, Andy J., Simon, M. Celeste
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Animals Antineoplastic Agents - pharmacology Basic Helix-Loop-Helix Transcription Factors - metabolism Biological Sciences Brain Neoplasms - metabolism Cancer Cell growth Cell Survival cell viability Chemotherapy drug therapy Gangrene Gene Expression Profiling Gene Expression Regulation, Neoplastic Genes Glioblastoma Glioblastoma - metabolism Humans Hypoxia Mesoderm - metabolism Mice Mice, Nude MicroRNA MicroRNAs MicroRNAs - metabolism Middle Aged mitogen-activated protein kinase Necrosis Neoplasm Transplantation neoplasms Neovascularization, Pathologic Oligonucleotide Array Sequence Analysis prognosis proto-oncogenes receptor protein-tyrosine kinase Receptor Protein-Tyrosine Kinases - metabolism Signal Transduction Signatures Tumors Young Adult
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Schreiben Sie den ersten Kommentar!