The presence of at least three alleles of the ADRB3 Trp64Arg (C/T) and UCP1 -3826A/G polymorphisms is associated with protection to overweight/obesity and with higher high-density lipoprotein cholesterol levels in Caucasian-Brazilian patients with type 2 diabetes

We investigated whether the -3826A/G polymorphism (rs1800592) of the uncoupling protein 1 gene (UCP1) and the Trp64Arg polymorphism (rs4994) of the β3-adrenergic receptor gene (ADRB3) are associated with type 2 diabetes mellitus (T2DM) and features of metabolic syndrome in a Brazilian-Caucasian popu...

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Veröffentlicht in:	Metabolic syndrome and related disorders 2014-02, Vol.12 (1), p.16-24
Hauptverfasser:	Brondani, Letícia A, Duarte, Guilherme C K, Canani, Luís H, Crispim, Daisy
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Alleles Blood Glucose Brazil Cholesterol, HDL - blood Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - ethnology Diabetes Mellitus, Type 2 - genetics European Continental Ancestry Group Female Genetic Predisposition to Disease Genotype Humans Ion Channels - genetics Male Metabolic Syndrome - blood Metabolic Syndrome - ethnology Metabolic Syndrome - genetics Middle Aged Mitochondrial Proteins - genetics Obesity - genetics Odds Ratio Overweight - genetics Polymorphism, Genetic Receptors, Adrenergic, beta-3 - genetics Risk Factors Surveys and Questionnaires Uncoupling Protein 1
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