Helicase–Primase Inhibitor Pritelivir for HSV-2 Infection

New treatments are needed for herpes simplex virus infection. In this placebo-controlled, randomized, dose-ranging trial, pritelivir, an inhibitor of the viral helicase–primase complex, reduced genital HSV-2 shedding in a dose-dependent fashion. Treatment of genital infections with the herpes simple...

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Veröffentlicht in:	The New England journal of medicine 2014-01, Vol.370 (3), p.201-210
Hauptverfasser:	Wald, Anna, Corey, Lawrence, Timmler, Burkhard, Magaret, Amalia, Warren, Terri, Tyring, Stephen, Johnston, Christine, Kriesel, John, Fife, Kenneth, Galitz, Lawrence, Stoelben, Susanne, Huang, Meei-Li, Selke, Stacy, Stobernack, Hans-Peter, Ruebsamen-Schaeff, Helga, Birkmann, Alexander
Format:	Artikel
Sprache:	eng
Schlagworte:	Administration, Oral Adult Aged Animal models Antiviral activity Antiviral Agents - administration & dosage Antiviral Agents - adverse effects Antiviral Agents - pharmacology Biological and medical sciences DNA helicase DNA, Viral - analysis Dose-Response Relationship, Drug Drug Administration Schedule Drug dosages Drug Resistance, Viral Drug therapy Female General aspects Herpes Genitalis - drug therapy Herpes Genitalis - virology Herpes simplex Herpes viruses Herpesvirus 2, Human - genetics Herpesvirus 2, Human - isolation & purification Humans Infections Male Medical sciences Middle Aged Phosphorylation Polymerase Chain Reaction Primase Pyridines - administration & dosage Pyridines - adverse effects Pyridines - pharmacology Thiazoles - administration & dosage Thiazoles - adverse effects Thiazoles - pharmacology Viral Load - drug effects Virus Shedding - drug effects
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