The effect of Clostridium botulinum toxin type A injections on motor unit activity of the deep digital flexor muscle in healthy sound Royal Dutch sport horses
Therapeutic reduction of the activity of the deep digital flexor (DDF) muscle may play a role in treatment of laminitic horses. Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type...
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| Veröffentlicht in: | The veterinary journal (1997) 2013-12, Vol.198, p.e147-e151 |
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| container_title | The veterinary journal (1997) |
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| creator | Wijnberg, Inge D. Hardeman, Lotte C. van der Meij, Bram R. Veraa, Stefanie Back, Willem van der Kolk, Johannes H. |
| description | Therapeutic reduction of the activity of the deep digital flexor (DDF) muscle may play a role in treatment of laminitic horses. Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type A on reduction of DDF muscle activity was measured in seven healthy, sound, adult Royal Dutch sport horses. C. botulinum toxin type A was injected using ultrasound and electromyographic (EMG) guidance. The effectiveness was assessed by interference pattern analysis (IPA) and motor unit action potential (MUAP) analysis. All needle EMG MUAP variables, along with IPA amplitude/turn and turns/s, were significantly reduced after C. botulinum toxin type A injections. The strongest effect occurred within the first 3days after injection. The reduced muscle induced by C. botulinum toxin type A may have benefits in the treatment of horses with laminitis. |
| doi_str_mv | 10.1016/j.tvjl.2013.09.050 |
| format | Article |
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Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type A on reduction of DDF muscle activity was measured in seven healthy, sound, adult Royal Dutch sport horses. C. botulinum toxin type A was injected using ultrasound and electromyographic (EMG) guidance. The effectiveness was assessed by interference pattern analysis (IPA) and motor unit action potential (MUAP) analysis. All needle EMG MUAP variables, along with IPA amplitude/turn and turns/s, were significantly reduced after C. botulinum toxin type A injections. The strongest effect occurred within the first 3days after injection. The reduced muscle induced by C. botulinum toxin type A may have benefits in the treatment of horses with laminitis.</description><identifier>ISSN: 1090-0233</identifier><identifier>EISSN: 1532-2971</identifier><identifier>DOI: 10.1016/j.tvjl.2013.09.050</identifier><identifier>PMID: 24360760</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>action potentials ; adults ; Animals ; botulinum toxin ; Botulinum Toxins, Type A - pharmacology ; Clostridium botulinum ; Clostridium botulinum toxin type A ; Deep digital flexor muscle ; Electromyography ; Electromyography - veterinary ; Equine ; Female ; Forelimb ; horses ; Horses - physiology ; laminitis ; Muscle, Skeletal - drug effects ; muscles ; Neuromuscular Agents - pharmacology ; parasympatholytics ; Recruitment, Neurophysiological - drug effects ; Recruitment, Neurophysiological - physiology ; sports ; ultrasonics</subject><ispartof>The veterinary journal (1997), 2013-12, Vol.198, p.e147-e151</ispartof><rights>2013 Elsevier Ltd</rights><rights>Copyright © 2013 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c380t-1f6810bd2b66729ef055332d92ab6058ea0c1d953ca4757fe9844a3ed9df8b4c3</citedby><cites>FETCH-LOGICAL-c380t-1f6810bd2b66729ef055332d92ab6058ea0c1d953ca4757fe9844a3ed9df8b4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S1090023313004784$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24360760$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Wijnberg, Inge D.</creatorcontrib><creatorcontrib>Hardeman, Lotte C.</creatorcontrib><creatorcontrib>van der Meij, Bram R.</creatorcontrib><creatorcontrib>Veraa, Stefanie</creatorcontrib><creatorcontrib>Back, Willem</creatorcontrib><creatorcontrib>van der Kolk, Johannes H.</creatorcontrib><title>The effect of Clostridium botulinum toxin type A injections on motor unit activity of the deep digital flexor muscle in healthy sound Royal Dutch sport horses</title><title>The veterinary journal (1997)</title><addtitle>Vet J</addtitle><description>Therapeutic reduction of the activity of the deep digital flexor (DDF) muscle may play a role in treatment of laminitic horses. Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type A on reduction of DDF muscle activity was measured in seven healthy, sound, adult Royal Dutch sport horses. C. botulinum toxin type A was injected using ultrasound and electromyographic (EMG) guidance. The effectiveness was assessed by interference pattern analysis (IPA) and motor unit action potential (MUAP) analysis. All needle EMG MUAP variables, along with IPA amplitude/turn and turns/s, were significantly reduced after C. botulinum toxin type A injections. The strongest effect occurred within the first 3days after injection. The reduced muscle induced by C. botulinum toxin type A may have benefits in the treatment of horses with laminitis.</description><subject>action potentials</subject><subject>adults</subject><subject>Animals</subject><subject>botulinum toxin</subject><subject>Botulinum Toxins, Type A - pharmacology</subject><subject>Clostridium botulinum</subject><subject>Clostridium botulinum toxin type A</subject><subject>Deep digital flexor muscle</subject><subject>Electromyography</subject><subject>Electromyography - veterinary</subject><subject>Equine</subject><subject>Female</subject><subject>Forelimb</subject><subject>horses</subject><subject>Horses - physiology</subject><subject>laminitis</subject><subject>Muscle, Skeletal - drug effects</subject><subject>muscles</subject><subject>Neuromuscular Agents - pharmacology</subject><subject>parasympatholytics</subject><subject>Recruitment, Neurophysiological - drug effects</subject><subject>Recruitment, Neurophysiological - physiology</subject><subject>sports</subject><subject>ultrasonics</subject><issn>1090-0233</issn><issn>1532-2971</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9kU2LFDEQhhtR3HX1D3jQHL3MWEn6K-BlGT9hQdDdc0gnle006c6YpIedP-NvNcOsHj0UVYSnXkI9VfWawpYCbd9P23yY_JYB5VsQW2jgSXVJG842THT0aZlBwAYY5xfVi5QmABB1zZ5XF6zmLXQtXFa_b0ckaC3qTIIlOx9Sjs64dSZDyKt3S5lyeHALycc9kmvilqnALiyJhIXMIYdI1sVlosrrweXjKSeXVIO4J8bdu6w8sR4fCjivSXssGWRE5fN4JCmsiyE_wrFAH9esR5L2IWYyhpgwvayeWeUTvnrsV9Xd50-3u6-bm-9fvu2ubzaa95A31LY9hcGwoW07JtBC03DOjGBqaKHpUYGmRjRcq7prOouir2vF0Qhj-6HW_Kp6d87dx_BrxZTl7JJG79WCYU2S1uJ0L1ZDQdkZ1TGkFNHKfXSzikdJQZ68yEmevMiTFwlCFi9l6c1j_jrMaP6t_BVRgLdnwKog1X10Sd79LAkNlOJQd4X4cCaw3OHgMMqkHS4ajYtFiDTB_e8HfwBKWaso</recordid><startdate>20131201</startdate><enddate>20131201</enddate><creator>Wijnberg, Inge D.</creator><creator>Hardeman, Lotte C.</creator><creator>van der Meij, Bram R.</creator><creator>Veraa, Stefanie</creator><creator>Back, Willem</creator><creator>van der Kolk, Johannes H.</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20131201</creationdate><title>The effect of Clostridium botulinum toxin type A injections on motor unit activity of the deep digital flexor muscle in healthy sound Royal Dutch sport horses</title><author>Wijnberg, Inge D. ; Hardeman, Lotte C. ; van der Meij, Bram R. ; Veraa, Stefanie ; Back, Willem ; van der Kolk, Johannes H.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c380t-1f6810bd2b66729ef055332d92ab6058ea0c1d953ca4757fe9844a3ed9df8b4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>action potentials</topic><topic>adults</topic><topic>Animals</topic><topic>botulinum toxin</topic><topic>Botulinum Toxins, Type A - pharmacology</topic><topic>Clostridium botulinum</topic><topic>Clostridium botulinum toxin type A</topic><topic>Deep digital flexor muscle</topic><topic>Electromyography</topic><topic>Electromyography - veterinary</topic><topic>Equine</topic><topic>Female</topic><topic>Forelimb</topic><topic>horses</topic><topic>Horses - physiology</topic><topic>laminitis</topic><topic>Muscle, Skeletal - drug effects</topic><topic>muscles</topic><topic>Neuromuscular Agents - pharmacology</topic><topic>parasympatholytics</topic><topic>Recruitment, Neurophysiological - drug effects</topic><topic>Recruitment, Neurophysiological - physiology</topic><topic>sports</topic><topic>ultrasonics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Wijnberg, Inge D.</creatorcontrib><creatorcontrib>Hardeman, Lotte C.</creatorcontrib><creatorcontrib>van der Meij, Bram R.</creatorcontrib><creatorcontrib>Veraa, Stefanie</creatorcontrib><creatorcontrib>Back, Willem</creatorcontrib><creatorcontrib>van der Kolk, Johannes H.</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>The veterinary journal (1997)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Wijnberg, Inge D.</au><au>Hardeman, Lotte C.</au><au>van der Meij, Bram R.</au><au>Veraa, Stefanie</au><au>Back, Willem</au><au>van der Kolk, Johannes H.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The effect of Clostridium botulinum toxin type A injections on motor unit activity of the deep digital flexor muscle in healthy sound Royal Dutch sport horses</atitle><jtitle>The veterinary journal (1997)</jtitle><addtitle>Vet J</addtitle><date>2013-12-01</date><risdate>2013</risdate><volume>198</volume><spage>e147</spage><epage>e151</epage><pages>e147-e151</pages><issn>1090-0233</issn><eissn>1532-2971</eissn><abstract>Therapeutic reduction of the activity of the deep digital flexor (DDF) muscle may play a role in treatment of laminitic horses. Clostridium botulinum toxin type A induces reduced muscle activity and has a spasmolytic effect in horses. In this study, the effectiveness of 200IU C. botulinum toxin type A on reduction of DDF muscle activity was measured in seven healthy, sound, adult Royal Dutch sport horses. C. botulinum toxin type A was injected using ultrasound and electromyographic (EMG) guidance. The effectiveness was assessed by interference pattern analysis (IPA) and motor unit action potential (MUAP) analysis. All needle EMG MUAP variables, along with IPA amplitude/turn and turns/s, were significantly reduced after C. botulinum toxin type A injections. The strongest effect occurred within the first 3days after injection. The reduced muscle induced by C. botulinum toxin type A may have benefits in the treatment of horses with laminitis.</abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>24360760</pmid><doi>10.1016/j.tvjl.2013.09.050</doi></addata></record> |
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| subjects | action potentials adults Animals botulinum toxin Botulinum Toxins, Type A - pharmacology Clostridium botulinum Clostridium botulinum toxin type A Deep digital flexor muscle Electromyography Electromyography - veterinary Equine Female Forelimb horses Horses - physiology laminitis Muscle, Skeletal - drug effects muscles Neuromuscular Agents - pharmacology parasympatholytics Recruitment, Neurophysiological - drug effects Recruitment, Neurophysiological - physiology sports ultrasonics |
| title | The effect of Clostridium botulinum toxin type A injections on motor unit activity of the deep digital flexor muscle in healthy sound Royal Dutch sport horses |
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